European Society for Organ Transplantation (ESOT) Consensus Statement on the Role of Pancreas Machine Perfusion to Increase the Donor Pool for Beta Cell Replacement Therapy.
| Title: | European Society for Organ Transplantation (ESOT) Consensus Statement on the Role of Pancreas Machine Perfusion to Increase the Donor Pool for Beta Cell Replacement Therapy. |
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| Authors: | Ferrer-Fàbrega J; Hepatobiliopancreatic Surgery and Liver and Pancreatic Transplantation Unit, Department of Surgery, Institute Clínic of Digestive and Metabolic Diseases (ICMDiM), Hospital Clínic, University of Barcelona, Barcelona, Spain.; Hepatic Oncology Unit, Barcelona Clínic Liver Cancer Group (BCLC), Hospital Clínic, Barcelona, Spain.; August Pi i Sunyer Biomedical, Research Institute (IDIBAPS), University of Barcelona, Barcelona, Spain.; Network for Biomedical Research in Hepatic and Digestive Diseases (CIBEREHD), Barcelona, Spain.; Mesnard B; Department of Urology and Transplantation Surgery, Nantes University Hospital, Nantes, France.; Centre for Research in Transplantation and Translational Immunology, INSERM UMR 1064, ITUN5, Nantes, France.; Messner F; Department of Visceral, Transplant and Thoracic Surgery, Medical University of Innsbruck, Innsbruck, Austria.; Doppenberg JB; Transplantation Center, Leiden University Medical Center, Leiden, Netherlands.; Drachenberg C; Department of Pathology, University of Maryland School of Medicine, Baltimore, MD, United States.; Engelse MA; Transplantation Center, Leiden University Medical Center, Leiden, Netherlands.; Johnson PRV; Research Group for Islet Transplantation, Nuffield Department of Surgical Sciences, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.; Leuvenink HGD; Department of Surgery, University Medical Center Groningen, Groningen, Netherlands.; Oniscu GC; Transplant Division, Department of Clinical Science, Intervention and Technology - CLINTEC, Karolinska Institutet, Stockholm, Sweden.; Papalois V; Imperial College Renal and Transplant Centre, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom.; Ploeg RJ; Oxford Transplant Centre, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.; Reichman TW; Ajmera Transplant Centre, Toronto General Hospital, University Health Network, Toronto, ON, Canada.; Scott WE 3rd; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom.; Vistoli F; Division of General Surgery and Transplantation, University of Pisa, Pisa, Italy.; Berney T; Division of Transplantation, Department of Surgery, University of Geneva Hospitals, Geneva, Switzerland.; Jacobs-Tulleneers-Thevissen D; Diabetes Research Center, Vrije Universiteit Brussel, Brussels, Belgium.; Department of Surgery, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium.; Kessaris N; Department of Nephrology and Transplantation, Guy's Hospital, London, United Kingdom.; Weissenbacher A; Department of Visceral, Transplant and Thoracic Surgery, Medical University of Innsbruck, Innsbruck, Austria.; Ogbemudia AE; Oxford Transplant Centre, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.; White S; Department of HPB and Transplant Surgery, NIHR BTRU in Organ Donation and Transplantation, The Freeman Hospital, The University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom.; Branchereau J; Department of Urology and Transplantation Surgery, Nantes University Hospital, Nantes, France.; Centre for Research in Transplantation and Translational Immunology, INSERM UMR 1064, ITUN5, Nantes, France. |
| Source: | Transplant international : official journal of the European Society for Organ Transplantation [Transpl Int] 2023 Jul 19; Vol. 36, pp. 11374. Date of Electronic Publication: 2023 Jul 19 (Print Publication: 2023). |
| Publication Type: | Journal Article; Consensus Statement |
| Language: | English |
| Journal Info: | Publisher: Frontiers Media S. A Country of Publication: Switzerland NLM ID: 8908516 Publication Model: eCollection Cited Medium: Internet ISSN: 1432-2277 (Electronic) Linking ISSN: 09340874 NLM ISO Abbreviation: Transpl Int Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2022- : Lausanne, Switzerland : Frontiers Media S. A.; Original Publication: [Heidelberg, FRG] : Springer International, 1988- |
| MeSH Terms: | Organ Preservation*/methods ; Organ Transplantation*; Perfusion/methods ; Humans ; Pancreas ; Tissue Donors |
| Abstract: | The advent of Machine Perfusion (MP) as a superior form of preservation and assessment for cold storage of both high-risk kidney's and the liver presents opportunities in the field of beta-cell replacement. It is yet unknown whether such techniques, when applied to the pancreas, can increase the pool of suitable donor organs as well as ameliorating the effects of ischemia incurred during the retrieval process. Recent experimental models of pancreatic MP appear promising. Applications of MP to the pancreas, needs refinement regarding perfusion protocols and organ viability assessment criteria. To address the "Role of pancreas machine perfusion to increase the donor pool for beta cell replacement," the European Society for Organ Transplantation (ESOT) assembled a dedicated working group comprising of experts to review literature pertaining to the role of MP as a method of improving donor pancreas quality as well as quantity available for transplant, and to develop guidelines founded on evidence-based reviews in experimental and clinical settings. These were subsequently refined during the Consensus Conference when this took place in Prague.; (Copyright © 2023 Ferrer-Fàbrega, Mesnard, Messner, Doppenberg, Drachenberg, Engelse, Johnson, Leuvenink, Oniscu, Papalois, Ploeg, Reichman, Scott, Vistoli, Berney, Jacobs-Tulleneers-Thevissen, Kessaris, Weissenbacher, Ogbemudia, White and Branchereau.) |
| Competing Interests: | JF-F received lecture fees from Bayer and AstraZeneca; consultancy fees from AstraZeneca. JF-F is the recipient of a grant supported by Instituto de Salud Carlos III (ISCIII) through the project “PI18/00161 (Optimization of pancreas transplant graft: A multicentric study of histo-morphological and functional characteristics of unaccepted organs.)” and co-funded by the European Union. BM received grand support from Institut Georges Lopez and the Hémarina Society. RP is an advisor to Bridge to Life Ltd. UK for issues on organ preservation. TR received consultancy fees from Sernova Corp and clinical trial support from Vertex Pharmaceuticals. WS is the co-founder and Chief Scientific Officer of ScubaTx Ltd. JB received logistic help/research grant from Institute Georges Lopez, Organ Revovery System, Hemarina, Bridge to life, and Xvivo. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. |
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| Contributed Indexing: | Keywords: ischemia-reperfusion injury; islet transplantation; machine perfusion; persufflation; whole pancreas transplantation |
| Entry Date(s): | Date Created: 20230807 Date Completed: 20230808 Latest Revision: 20260127 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC10402633 |
| DOI: | 10.3389/ti.2023.11374 |
| PMID: | 37547751 |
| Database: | MEDLINE |
Journal Article; Consensus Statement