Screw Osteointegration-Increasing Biomechanical Resistance to Pull-Out Effect.
| Title: | Screw Osteointegration-Increasing Biomechanical Resistance to Pull-Out Effect. |
|---|---|
| Authors: | Costăchescu B; 'Gr. T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania.; 'Prof. Dr. N. Oblu' Emergency Clinical Hospital, 700309 Iasi, Romania.; Niculescu AG; Research Institute of the University of Bucharest-ICUB, University of Bucharest, 050657 Bucharest, Romania.; Department of Science and Engineering of Oxide Materials and Nanomaterials, Politehnica University of Bucharest, 011061 Bucharest, Romania.; Grumezescu AM; Research Institute of the University of Bucharest-ICUB, University of Bucharest, 050657 Bucharest, Romania.; Department of Science and Engineering of Oxide Materials and Nanomaterials, Politehnica University of Bucharest, 011061 Bucharest, Romania.; Academy of Romanian Scientists, Ilfov No. 3, 050044 Bucharest, Romania.; Teleanu DM; 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania. |
| Source: | Materials (Basel, Switzerland) [Materials (Basel)] 2023 Aug 11; Vol. 16 (16). Date of Electronic Publication: 2023 Aug 11. |
| Publication Type: | Journal Article; Review |
| Language: | English |
| Journal Info: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101555929 Publication Model: Electronic Cited Medium: Print ISSN: 1996-1944 (Print) Linking ISSN: 19961944 NLM ISO Abbreviation: Materials (Basel) Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Publication: May 2010- : Basel, Switzerland : MDPI; Original Publication: Basel, Switzerland : Molecular Diversity Preservation International, 2008-2010. |
| Abstract: | Spinal disorders cover a broad spectrum of pathologies and are among the most prevalent medical conditions. The management of these health issues was noted to be increasingly based on surgical interventions. Spinal fixation devices are often employed to improve surgery outcomes, increasing spinal stability, restoring structural integrity, and ensuring functionality. However, most of the currently used fixation tools are fabricated from materials with very different mechanical properties to native bone that are prone to pull-out effects or fail over time, requiring revision procedures. Solutions to these problems presently exploited in practice include the optimal selection of screw shape and size, modification of insertion trajectory, and utilization of bone cement to reinforce fixation constructs. Nevertheless, none of these methods are without risks and limitations. An alternative option to increasing biomechanical resistance to the pull-out effect is to tackle bone regenerative capacity and focus on screw osteointegration properties. Osteointegration was reportedly enhanced through various optimization strategies, including use of novel materials, surface modification techniques (e.g., application of coatings and topological optimization), and utilization of composites that allow synergistic effects between constituents. In this context, this paper takes a comprehensive path, starting with a brief presentation of spinal fixation devices, moving further to observations on how the pull-out strength can be enhanced with existing methods, and further focusing on techniques for implant osteointegration improvement. |
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| Contributed Indexing: | Keywords: bone fixation; material optimization; osteointegration; pull-out effect; reinforcement strategies; spinal fixation devices; spinal screws |
| Entry Date(s): | Date Created: 20230826 Latest Revision: 20230829 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC10456840 |
| DOI: | 10.3390/ma16165582 |
| PMID: | 37629873 |
| Database: | MEDLINE |
Journal Article; Review