Predictive factors of urinary tract infections caused by extended-spectrum β-lactamase-producing Escherichia coli in children: a prospective Tunisian study.
| Title: | Predictive factors of urinary tract infections caused by extended-spectrum β-lactamase-producing Escherichia coli in children: a prospective Tunisian study. |
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| Authors: | Boussetta A; Service de pédiatrie, Hôpital Charles Nicolle / Université de Tunis El Manar, Faculté de médecine de Tunis.; Kharbach N; Service de pédiatrie, Hôpital Charles Nicolle / Université de Tunis El Manar, Faculté de médecine de Tunis.; Abdellatif A; Service de pédiatrie, Hôpital Charles Nicolle / Université de Tunis El Manar, Faculté de médecine de Tunis.; Karray A; Service d'urologie, Hôpital Charles Nicolle / Faculté de médecine de Tunis.; Jellouli M; Service de pédiatrie, Hôpital Charles Nicolle / Université de Tunis El Manar, Faculté de médecine de Tunis.; Gargah T; Service de pédiatrie, Hôpital Charles Nicolle / Université de Tunis El Manar, Faculté de médecine de Tunis. |
| Source: | La Tunisie medicale [Tunis Med] 2023 Feb 11; Vol. 101 (2), pp. 285-291. Date of Electronic Publication: 2023 Feb 11. |
| Publication Type: | Observational Study; Journal Article |
| Language: | English |
| Journal Info: | Publisher: Societe Tunisienne Des Sciences Medicales Country of Publication: Tunisia NLM ID: 0413766 Publication Model: Electronic Cited Medium: Internet ISSN: 2724-7031 (Electronic) Linking ISSN: 00414131 NLM ISO Abbreviation: Tunis Med Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Tunis : Societe Tunisienne Des Sciences Medicales |
| MeSH Terms: | Urinary Tract Infections*/epidemiology; Anti-Bacterial Agents/therapeutic use ; Young Adult ; Child ; Humans ; Female ; Child, Preschool ; Male ; Prospective Studies ; Cefixime ; Escherichia coli ; beta-Lactamases |
| Abstract: | Aim: To identify the predictive factors for the occurrence of community-acquired urinary tract infections caused by Extended-Spectrum β-Lactamase-Producing Escherichia coli in children.; Methods: This was a single-center prospective observational study of children and young adults with community-acquired urinary tract infections caused by Extended-Spectrum β-Lactamase-Producing Escherichia coli. The study was conducted in the pediatric nephrology department in Charles Nicolle Hospital, Tunis, Tunisia from January 1st, 2019, to December 31, 2020. Patients ≤20 years with community-acquired urinary tract infection caused by Escherichia coli were included prospectively in our study.; Results: We collected 290 urinary tract infections in 218 patients, including 92 urinary tract infections due to Extended-Spectrum β-Lactamase-Producing Escherichia coli. The mean age of children was 50.10±54.28 months, with a female predominance in 65.2% of cases. Risk factors for the acquisition of multidrug-resistant bacteria were antibiotic therapy in the previous three months, antibiotic prophylaxis, hospitalization in the year preceding the urinary tract infections, and outpatient care in the previous six months (p < 0.05). Resistance to Ceftazidime, Cefotaxime, Cefixime, Gentamicin and Ofloxacin was significantly associated with the presence of an Extended-Spectrum β-Lactamase strain. Antibiotic resistance was significantly more observed in the age group above 6 years. Co-habitation with health care worker was a risk factor for resistance to Amoxicillin-Clavulanic Acid.; Conclusion: Understanding the epidemiological profile and risk factors for ESBL-producing UTIs, including Extended-Spectrum β-Lactamase-producing Escherichia coli in the pediatric population, could improve the therapeutic approach and lead to more rational prescription of antibiotics. |
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| Substance Nomenclature: | 97I1C92E55 (Cefixime); 0 (Anti-Bacterial Agents); EC 3.5.2.6 (beta-Lactamases) |
| Entry Date(s): | Date Created: 20230908 Date Completed: 20230911 Latest Revision: 20240601 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC11138556 |
| PMID: | 37682274 |
| Database: | MEDLINE |
Observational Study; Journal Article