Incidence of Surgical Site Infection Despite Preoperative Cefazolin Administration in Total Knee Arthroplasty Patients: A Tertiary Hospital Experience.
| Title: | Incidence of Surgical Site Infection Despite Preoperative Cefazolin Administration in Total Knee Arthroplasty Patients: A Tertiary Hospital Experience. |
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| Authors: | Mikwar Z; General Surgery, King Abdulaziz Medical City, Jeddah, SAU.; AlRajhi B; College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, SAU.; Saimaldaher BW; College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, SAU.; Al-Magrabi A; College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, SAU.; Khoja A; College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, SAU.; Abushouk A; College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, SAU. |
| Source: | Cureus [Cureus] 2023 Aug 22; Vol. 15 (8), pp. e43912. Date of Electronic Publication: 2023 Aug 22 (Print Publication: 2023). |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Cureus, Inc Country of Publication: United States NLM ID: 101596737 Publication Model: eCollection Cited Medium: Print ISSN: 2168-8184 (Print) Linking ISSN: 21688184 NLM ISO Abbreviation: Cureus Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: Palo Alto, CA : Cureus, Inc. |
| Abstract: | Introduction: Surgical site infection (SSI) is an infection that occurs after surgery on the incision site. Cefazolin is an old-generation antibiotic that decreases the risk of SSI. This study aimed to determine the relationship between the incidence of SSI, cefazolin administration, and the factors contributing to the relationship between them.; Methods: This is a retrospective study that used a data collection sheet to collect variables from the medical records of patients who underwent total knee arthroplasty (TKA) between 2016 and 2020. We looked mainly for the type of antibiotics given preoperatively, the number of doses given, discontinuation of antibiotics postoperatively, length of hospital stay, intensive care unit (ICU) admission, and SSI occurrence. Results: A total of 195 patients were included. The majority (87.8%) were given two grams of cefazolin. Patients who have taken one gram of cefazolin had a slightly higher hospital stay than those who took two grams. However, all the patients did not develop an SSI.; Conclusion: There was no incidence of SSI despite preoperative cefazolin administration in TKA patients. Patients who received higher doses of cefazolin had a shorter length of hospital stay.; (Copyright © 2023, Mikwar et al.) |
| Competing Interests: | The authors have declared that no competing interests exist. |
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| Contributed Indexing: | Keywords: cefazolin; saudi arabia; surgical site infection; tertiary hospital; total knee replacement |
| Entry Date(s): | Date Created: 20230925 Latest Revision: 20230926 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC10512619 |
| DOI: | 10.7759/cureus.43912 |
| PMID: | 37746365 |
| Database: | MEDLINE |
Journal Article