Hedgehog signaling is required for endometrial remodeling and myometrial homeostasis in the cycling mouse uterus.
| Title: | Hedgehog signaling is required for endometrial remodeling and myometrial homeostasis in the cycling mouse uterus. |
|---|---|
| Authors: | Roberson EC; Department of Pediatrics, Section of Developmental Biology, University of Colorado Anschutz Medical School, Aurora, CO 80045, USA.; Tran NK; Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.; Godambe AN; Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.; Mark H; Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.; Nguimtsop M; Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.; Rust T; Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.; Ung E; Department of Pediatrics, Section of Developmental Biology, University of Colorado Anschutz Medical School, Aurora, CO 80045, USA.; Barker LJ; Department of Pediatrics, Section of Developmental Biology, University of Colorado Anschutz Medical School, Aurora, CO 80045, USA.; Fitch RD; Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.; Wallingford JB; Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA. |
| Source: | IScience [iScience] 2023 Sep 20; Vol. 26 (10), pp. 107993. Date of Electronic Publication: 2023 Sep 20 (Print Publication: 2023). |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: [Cambridge, MA] : Cell Press, [2018]- |
| Abstract: | Decades of work demonstrate that the mammalian estrous cycle is controlled by cycling steroid hormones. However, the signaling mechanisms that act downstream, linking hormonal action to the physical remodeling of the cycling uterus, remain unclear. To address this issue, we analyzed gene expression at all stages of the mouse estrous cycle. Strikingly, we found that several genetic programs well-known to control tissue morphogenesis in developing embryos displayed cyclical patterns of expression. We find that most of the genetic architectures of Hedgehog signaling (ligands, receptors, effectors, and transcription factors) are transcribed cyclically in the uterus, and that conditional disruption of the Hedgehog receptor smoothened not only elicits a failure of normal cyclical thickening of the endometrial lining but also induces aberrant deformation of the uterine smooth muscle. Together, our data shed light on the mechanisms underlying normal uterine remodeling specifically and cyclical gene expression generally.; (© 2023 The Authors.) |
| Competing Interests: | The authors declare no competing interests. |
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| Grant Information: | F32 HD095618 United States HD NICHD NIH HHS; R01 HD085901 United States HD NICHD NIH HHS; R01 HL117164 United States HL NHLBI NIH HHS; R24 HD102061 United States HD NICHD NIH HHS |
| Contributed Indexing: | Keywords: Biological sciences; Cell biology; Developmental biology |
| Entry Date(s): | Date Created: 20231009 Latest Revision: 20240926 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC10551904 |
| DOI: | 10.1016/j.isci.2023.107993 |
| PMID: | 37810243 |
| Database: | MEDLINE |
Journal Article