Tau trajectory in Alzheimer's disease: Evidence from the connectome-based computational models.
| Title: | Tau trajectory in Alzheimer's disease: Evidence from the connectome-based computational models. |
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| Authors: | Bitra VR; School of Pharmacy, Faculty of Health Sciences, University of Botswana, P/Bag-0022, Gaborone, Botswana. Electronic address: bitrav@ub.ac.bw.; Challa SR; Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine, Peoria, IL 61614, USA; KVSR Siddartha College of Pharmaceutical Sciences, Vijayawada, Andhra Pradesh, India.; Adiukwu PC; School of Pharmacy, Faculty of Health Sciences, University of Botswana, P/Bag-0022, Gaborone, Botswana.; Rapaka D; Pharmacology Division, D.D.T. College of Medicine, Gaborone, Botswana. Electronic address: deepthirapaka7@gmail.com. |
| Source: | Brain research bulletin [Brain Res Bull] 2023 Oct 15; Vol. 203, pp. 110777. Date of Electronic Publication: 2023 Oct 07. |
| Publication Type: | Journal Article; Review; Research Support, Non-U.S. Gov't |
| Language: | English |
| Journal Info: | Publisher: Elsevier Science Country of Publication: United States NLM ID: 7605818 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2747 (Electronic) Linking ISSN: 03619230 NLM ISO Abbreviation: Brain Res Bull Subsets: MEDLINE |
| Imprint Name(s): | Publication: New York Ny : Elsevier Science; Original Publication: Phoenix, N. Y. ANKHO International Inc. |
| MeSH Terms: | Alzheimer Disease*/diagnostic imaging ; Alzheimer Disease*/pathology ; Cognitive Dysfunction*/pathology ; Connectome*; tau Proteins/metabolism ; Brain/metabolism ; Amyloid beta-Peptides/metabolism ; Humans ; Magnetic Resonance Imaging ; Computer Simulation ; Positron-Emission Tomography |
| Abstract: | Alzheimer's disease (AD) is a progressive neurodegenerative disorder with an impairment of cognition and memory. Current research on connectomics have now related changes in the network organization in AD to the patterns of accumulation and spread of amyloid and tau, providing insights into the neurobiological mechanisms of the disease. In addition, network analysis and modeling focus on particular use of graphs to provide intuition into key organizational principles of brain structure, that stipulate how neural activity propagates along structural connections. The utility of connectome-based computational models aids in early predicting, tracking the progression of biomarker-directed AD neuropathology. In this article, we present a short review of tau trajectory, the connectome changes in tau pathology, and the dependent recent connectome-based computational modelling approaches for tau spreading, reproducing pragmatic findings, and developing significant novel tau targeted therapies.; (Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.) |
| Competing Interests: | Declaration of Competing Interest The authors declare no conflict of interest. |
| Contributed Indexing: | Keywords: Alzheimer's disease; Connectivity; Connectome; Hubs; Tau |
| Substance Nomenclature: | 0 (tau Proteins); 0 (Amyloid beta-Peptides) |
| Entry Date(s): | Date Created: 20231009 Date Completed: 20231023 Latest Revision: 20231106 |
| Update Code: | 20260130 |
| DOI: | 10.1016/j.brainresbull.2023.110777 |
| PMID: | 37813312 |
| Database: | MEDLINE |
Journal Article; Review; Research Support, Non-U.S. Gov't