Applying Natural Language Processing to ClinicalTrials.gov: mRNA cancer vaccine case study.
| Title: | Applying Natural Language Processing to ClinicalTrials.gov: mRNA cancer vaccine case study. |
|---|---|
| Authors: | Vora B; Clinical Pharmacology, Genentech, Inc., South San Francisco, California, USA.; Kuruvilla D; Clinical Pharmacology, Genentech, Inc., South San Francisco, California, USA.; Kim C; Computational Sciences, Genentech, Inc., South San Francisco, California, USA.; Wu M; Computational Sciences, Genentech, Inc., South San Francisco, California, USA.; Shemesh CS; Clinical Pharmacology, Genentech, Inc., South San Francisco, California, USA.; Roth GA; Preclinical and Translational PKPD, Genentech, Inc., South San Francisco, California, USA. |
| Source: | Clinical and translational science [Clin Transl Sci] 2023 Dec; Vol. 16 (12), pp. 2417-2420. Date of Electronic Publication: 2023 Oct 12. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: WileyBlackwell Pub Country of Publication: United States NLM ID: 101474067 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1752-8062 (Electronic) Linking ISSN: 17528054 NLM ISO Abbreviation: Clin Transl Sci Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Malden, MA : WileyBlackwell Pub., 2008- |
| MeSH Terms: | Cancer Vaccines*/genetics ; Neoplasms*/genetics ; Neoplasms*/therapy; RNA, Messenger/genetics ; Humans ; Natural Language Processing ; Data Mining |
| Abstract: | Recently, biotechnology and pharmaceutical industries have made strides to adopt and implement Natural Language Processing (NLP) to address challenges faced when extracting and synthesizing high volumes of information found in unstructured and semistructured text. Here we present, and provide a summary of the findings from, a use case where NLP and text mining methodologies were used to extract clinical trial data from ClinicalTrials.gov for mRNA cancer vaccines.; (© 2023 Genentech, Inc. Clinical and Translational Science published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeutics.) |
| References: | Clin Pharmacol Ther. 2020 Apr;107(4):886-902. (PMID: 31863452); Clin Transl Sci. 2023 Dec;16(12):2417-2420. (PMID: 37828818); Curr Opin Immunol. 2020 Aug;65:14-20. (PMID: 32244193); J Biomed Inform. 2007 Feb;40(1):30-43. (PMID: 16697710); Yearb Med Inform. 2022 Aug;31(1):243-253. (PMID: 35654422); Nat Rev Drug Discov. 2021 Nov;20(11):817-838. (PMID: 34433919); Vaccines (Basel). 2021 May 15;9(5):. (PMID: 34063388) |
| Substance Nomenclature: | 0 (Cancer Vaccines); 0 (RNA, Messenger) |
| Entry Date(s): | Date Created: 20231013 Date Completed: 20231216 Latest Revision: 20240417 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC10719489 |
| DOI: | 10.1111/cts.13648 |
| PMID: | 37828818 |
| Database: | MEDLINE |
Journal Article