Diffuse Myocardial Fibrosis is Uncommon in People with Perinatally Acquired Human Immunodeficiency Virus Infection.
| Title: | Diffuse Myocardial Fibrosis is Uncommon in People with Perinatally Acquired Human Immunodeficiency Virus Infection. |
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| Authors: | Williams JL; Duke University Medical Center.; Hung F; Duke University School of Medicine.; Jenista E; Duke University Medical Center.; Barker P; Duke University Medical Center.; Chakraborty H; Duke Clinic Research Institute.; Kim R; Duke University Medical Center.; McCrary AW; Duke University Medical Center.; Shah SH; Duke Clinic Research Institute and Duke University School of Medicine.; Thielman N; Duke University Medical Center.; Bloomfield GS; Duke Clinic Research Institute and Duke University School of Medicine. |
| Source: | Research square [Res Sq] 2023 Sep 26. Date of Electronic Publication: 2023 Sep 26. |
| Publication Type: | Preprint; Journal Article |
| Language: | English |
| Journal Info: | Country of Publication: United States NLM ID: 101768035 Publication Model: Electronic Cited Medium: Internet ISSN: 2693-5015 (Electronic) Linking ISSN: 26935015 NLM ISO Abbreviation: Res Sq Subsets: PubMed not MEDLINE |
| Abstract: | Background: Cardiovascular disease (CVD) remains a leading cause of death in people living with HIV. Myocardial fibrosis is well-described in HIV infection acquired in adulthood. We evaluate the burden of fibrosis by cardiac magnetic resonance in people with perinatal HIV infection.; Methods: Individuals with perinatally acquired HIV (pnHIV) diagnosed before 10 years-old and on antiretroviral treatment for ≥ 6 months were matched with uninfected controls. Patients with significant cardiometabolic co-morbidities and pregnancy were excluded. Diffuse fibrosis was assessed by cardiac magnetic resonance (CMR). with native T1 mapping for calculation of extracellular volume fraction (ECV). Viability was assessed with late gadolinium enhancement. The normality of fibrosis was assessed using the Komogrov-Smirnov test. Fibrosis between the groups was analyzed using a Mann-Whitney U test, as the data was not normally distributed. Statistical significance was defined as a p-valve < 0.05.; Results: Fourteen adults with pnHIV group and 26 controls (71% female and 86% Black race) were assessed. The average (± standard deviation) age in the study group was 29 (± 4.3) years-old. All pnHIV had been on ART for decades. Demographic data, CMR functional/volumetric data, and pre-contrast T1 mapping values were similar between groups. Diastolic function was normal in 50% of pnHIV patients and indeterminate in most of the remainder (42%). There was no statistically significant difference in ECV between groups; p = 0.24.; Conclusion: Perinatally-acquired HIV was not associated with diffuse myocardial fibrosis. Early exposure to ART may be cardioprotective against development of myocardial fibrosis in patients with perinatal HIV. |
| Competing Interests: | Competing interests The authors declare they have no competing interests. |
| Comments: | Update in: AIDS Res Ther. 2024 Mar 4;21(1):13. doi: 10.1186/s12981-024-00598-4.. (PMID: 38439093) |
| Grant Information: | R56 HL152803 United States HL NHLBI NIH HHS |
| Contributed Indexing: | Keywords: HIV; myocardial fibrosis; perinatal infection |
| Entry Date(s): | Date Created: 20231016 Latest Revision: 20240709 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC10571634 |
| DOI: | 10.21203/rs.3.rs-3370759/v1 |
| PMID: | 37841862 |
| Database: | MEDLINE |
Preprint; Journal Article