The effect of dietary interventions on pain and quality of life in women diagnosed with endometriosis: a prospective study with control group.
| Title: | The effect of dietary interventions on pain and quality of life in women diagnosed with endometriosis: a prospective study with control group. |
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| Authors: | van Haaps AP; Department of Reproductive Medicine, Amsterdam University Medical Centers, Vrije Universiteit, Amsterdam, The Netherlands.; Endometriosis Center, Amsterdam University Medical Centers, Academic Medical Center, Amsterdam, The Netherlands.; Amsterdam Reproduction and Development Research Institute, Amsterdam, The Netherlands.; Wijbers JV; Endometriosis Center, Amsterdam University Medical Centers, Academic Medical Center, Amsterdam, The Netherlands.; Faculty of Health, Nutrition & Sport, The Hague University of Applied Sciences, Den Haag, The Netherlands.; Schreurs AMF; Department of Reproductive Medicine, Amsterdam University Medical Centers, Vrije Universiteit, Amsterdam, The Netherlands.; Endometriosis Center, Amsterdam University Medical Centers, Academic Medical Center, Amsterdam, The Netherlands.; Amsterdam Reproduction and Development Research Institute, Amsterdam, The Netherlands.; Vlek S; Endometriosis Center, Amsterdam University Medical Centers, Academic Medical Center, Amsterdam, The Netherlands.; Department of Surgery, Amsterdam University Medical Centers, Vrije Universiteit, Amsterdam, The Netherlands.; Tuynman J; Endometriosis Center, Amsterdam University Medical Centers, Academic Medical Center, Amsterdam, The Netherlands.; Department of Surgery, Amsterdam University Medical Centers, Vrije Universiteit, Amsterdam, The Netherlands.; De Bie B; Endometriose Stichting, Dutch Patient Organization for Endometriosis, Sittard, The Netherlands.; de Vogel AL; Dietician Practice Aileen de Vogel, Dordrecht, The Netherlands.; van Wely M; Department of Reproductive Medicine, Amsterdam University Medical Centers, Academic Medical Center, Amsterdam, The Netherlands.; Mijatovic V; Department of Reproductive Medicine, Amsterdam University Medical Centers, Vrije Universiteit, Amsterdam, The Netherlands.; Endometriosis Center, Amsterdam University Medical Centers, Academic Medical Center, Amsterdam, The Netherlands.; Amsterdam Reproduction and Development Research Institute, Amsterdam, The Netherlands. |
| Source: | Human reproduction (Oxford, England) [Hum Reprod] 2023 Dec 04; Vol. 38 (12), pp. 2433-2446. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Language: | English |
| Journal Info: | Publisher: Oxford University Press Country of Publication: England NLM ID: 8701199 Publication Model: Print Cited Medium: Internet ISSN: 1460-2350 (Electronic) Linking ISSN: 02681161 NLM ISO Abbreviation: Hum Reprod Subsets: MEDLINE |
| Imprint Name(s): | Publication: Oxford, UK : Oxford University Press; Original Publication: Oxford ; Washington, DC : Published for the European Society of Human Reproduction and Embryology by IRL Press, [c1986- |
| MeSH Terms: | Endometriosis*/complications; Pelvic Pain/therapy ; Pelvic Pain/complications ; Humans ; Female ; Prospective Studies ; Quality of Life ; Control Groups ; Pilot Projects |
| Abstract: | Study Question: What is the influence of dietary interventions, namely the low fermentable oligo-, di-, mono-saccharides, and polyols (Low FODMAP) diet and endometriosis diet, on endometriosis-related pain and quality of life (QoL) compared to a control group?; Summary Answer: After adhering to a dietary intervention for 6 months, women with endometriosis reported less pain and an improved QoL compared to baseline whereas, compared to the control group, they reported less bloating and a better QoL in 3 of 11 domains.; What Is Known Already: Standard endometriosis treatment can be insufficient or may be accompanied by unacceptable side effects. This has resulted in an increasing interest in self-management strategies, including the appliance of the Low FODMAP diet and the endometriosis diet (an experience-based avoidance diet, developed by women with endometriosis). The Low FODMAP diet has previously been found effective in reducing endometriosis-related pain symptoms, whereas only limited studies are available on the efficacy of the endometriosis diet. A survey study recently found the endometriosis diet effective in improving QoL but currently no guidelines on use of the diet exist.; Study Design, Size, Duration: A prospective one-center pilot study was performed between April 2021 and December 2022. Participants could choose between adherence to a diet-the Low FODMAP diet or endometriosis diet-or no diet (control group). Women adhering to a diet received extensive guidance from a dietician in training. The follow-up period was 6 months for all three groups. For all outcomes, women adhering to the diets were compared to their baseline situation and to the control group.; Participants/materials, Setting, Methods: We included women diagnosed with endometriosis (surgically and/or by radiologic imaging) who reported pain scores ≥3 cm on the visual analogue score (0-10 cm) for dysmenorrhea, deep dyspareunia, and/or chronic pelvic pain. The primary endpoint focused on pain reduction for all pain symptoms, including dysuria, bloating, and tiredness. Secondary endpoints, assessed via questionnaires, focused on QoL, gastro-intestinal health, and diet adherence.; Main Results and the Role of Chance: A total of 62 participants were included in the low FODMAP diet (n = 22), endometriosis diet (n = 21), and control group (n = 19). Compared to their baseline pain scores, participants adhering to a diet reported less pain in four of six symptoms (range P |
| Comments: | Comment in: Hum Reprod. 2024 Apr 3;39(4):865-866. doi: 10.1093/humrep/deae021.. (PMID: 38366917); Comment in: Hum Reprod. 2024 Apr 3;39(4):863-864. doi: 10.1093/humrep/deae022.. (PMID: 38366950) |
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| Contributed Indexing: | Keywords: dietary intervention; endometriosis; endometriosis diet; low FODMAP diet; low fermentable oligo-, di-, mono-saccharides, and polyols; pain; quality of life; self-management |
| Entry Date(s): | Date Created: 20231025 Date Completed: 20231205 Latest Revision: 20241119 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC10754387 |
| DOI: | 10.1093/humrep/dead214 |
| PMID: | 37877417 |
| Database: | MEDLINE |
Journal Article; Research Support, Non-U.S. Gov't