Outbreak of Pandoraea commovens Infections among Non-Cystic Fibrosis Intensive Care Patients, Germany, 2019-2021.
| Title: | Outbreak of Pandoraea commovens Infections among Non-Cystic Fibrosis Intensive Care Patients, Germany, 2019-2021. |
|---|---|
| Authors: | Kruis T; Menzel P; Schwarzer R; Wiesener S; Schoenrath F; Klefisch F; Stegemann M; Pfäfflin F |
| Source: | Emerging infectious diseases [Emerg Infect Dis] 2023 Nov; Vol. 29 (11), pp. 2229-2237. |
| Publication Type: | Journal Article; Review |
| Language: | English |
| Journal Info: | Publisher: National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC) Country of Publication: United States NLM ID: 9508155 Publication Model: Print Cited Medium: Internet ISSN: 1080-6059 (Electronic) Linking ISSN: 10806040 NLM ISO Abbreviation: Emerg Infect Dis Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Atlanta, GA : National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC), [1995- |
| MeSH Terms: | Cystic Fibrosis*/complications ; Cystic Fibrosis*/epidemiology ; Burkholderiaceae*/genetics ; Anti-Infective Agents*; Germany/epidemiology ; Humans ; Gram-Negative Bacteria ; Trimethoprim, Sulfamethoxazole Drug Combination |
| Abstract: | Pandoraea spp. are gram-negative, nonfermenting rods mainly known to infect patients with cystic fibrosis (CF). Outbreaks have been reported from several CF centers. We report a Pandoraea spp. outbreak comprising 24 non-CF patients at a large university hospital and a neighboring heart center in Germany during July 2019-December 2021. Common features in the patients were critical illness, invasive ventilation, antimicrobial pretreatment, and preceding surgery. Complicated and relapsing clinical courses were observed in cases with intraabdominal infections but not those with lower respiratory tract infections. Genomic analysis of 15 isolates identified Pandoraea commovens as the genetically most similar species and confirmed the clonality of the outbreak strain, designated P. commovens strain LB-19-202-79. The strain exhibited resistance to most antimicrobial drugs except ampicillin/sulbactam, imipenem, and trimethoprim/sulfamethoxazole. Our findings suggest Pandoraea spp. can spread among non-CF patients and underscore that clinicians and microbiologists should be vigilant in detecting and assessing unusual pathogens. |
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| Contributed Indexing: | Keywords: Germany; Pandoraea commovens; antimicrobial resistance; bacteria; non–cystic fibrosis patients; outbreak; respiratory infections |
| Substance Nomenclature: | 0 (Anti-Infective Agents); 8064-90-2 (Trimethoprim, Sulfamethoxazole Drug Combination) |
| Entry Date(s): | Date Created: 20231025 Date Completed: 20231026 Latest Revision: 20231112 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC10617358 |
| DOI: | 10.3201/eid2911.230493 |
| PMID: | 37877517 |
| Database: | MEDLINE |
Journal Article; Review