Comparing long-term sexual dysfunction across different uterine cancer treatment modalities.
| Title: | Comparing long-term sexual dysfunction across different uterine cancer treatment modalities. |
|---|---|
| Authors: | Yoder AK; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.; Lakomy DS; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO.; Wu J; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX; The University of Texas School of Public Health, Houston, TX.; Andring LM; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.; Corrigan KL; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.; Fellman B; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX.; Jhingran A; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.; Klopp AH; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.; Colbert LE; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.; Soliman PT; Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX.; Frumovitz MM; Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX.; Peterson SK; Department of Behavioral Science, The University of Texas MD Anderson Cancer Center, Houston, TX.; Lin LL; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX. Electronic address: LLLin@mdanderson.org. |
| Source: | Brachytherapy [Brachytherapy] 2024 Jan-Feb; Vol. 23 (1), pp. 1-9. Date of Electronic Publication: 2023 Oct 31. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural |
| Language: | English |
| Journal Info: | Publisher: Elsevier, 2002- Country of Publication: United States NLM ID: 101137600 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-1449 (Electronic) Linking ISSN: 15384721 NLM ISO Abbreviation: Brachytherapy Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: New York, NY : Elsevier, 2002- |
| MeSH Terms: | Brachytherapy*/methods ; Uterine Neoplasms*/radiotherapy ; Sexual Dysfunction, Physiological*/etiology; Hot Flashes/radiotherapy ; Hot Flashes/etiology ; Humans ; Female ; Cross-Sectional Studies |
| Abstract: | Introduction: The objective of this study was to assess differences in long-term sexual and menopausal side effects after uterine cancer treatment among treatment modalities.; Methods and Materials: This is a cross-sectional study that examined women treated for uterine cancer from 2006-2018. Eligible women included those who underwent a hysterectomy/bilateral salpino-oophorectemy alone (HS), with brachytherapy (BT), or with external beam radiation therapy (EBRT). A noncancer cohort of women who underwent a hysterectomy/BSO for benign indications were also identified (non-CA). To compare outcomes, we utilized a shortened form of the female sexual function index (FSFI) and the menopause survey, which consists of 3 subscales: hot flashes, vaginal symptoms, and urinary symptoms. Demographic, comorbidity, and other treatment variables were collected. Survey totals were compared across cohorts using ANOVA tests and logistic regression.; Results: A total of 284 women completed the Menopause Survey (Non-CA 64, HS 60, BT 69, EBRT 91); 116 women reported sexual activity in the last 4 weeks and completed the FSFI (NC 32, HS 21, BT 31, EBRT 32). The mean FSFI score for the entire cohort was 11.4 (SD 4.16), which indicates poor sexual function. There was no significant difference between any cohort in the overall FSFI score (p = 0.708) or in any of the FSFI subscales (all p > 0.05). On univariate analysis, BT was associated with fewer menopausal hot flashes and vaginal symptoms compared to the non-CA cohort (p < 0.05), which did not persist on multivariable analysis.; Conclusion: There was no significant difference in sexual dysfunction or menopausal symptoms in those treated for uterine cancer with or without adjuvant radiation. Most patients reported poor sexual function.; (Copyright © 2023 American Brachytherapy Society. Published by Elsevier Inc. All rights reserved.) |
| Competing Interests: | Disclosures: Supported in part by Cancer Center Support (Core) Grant P30 CA016672 from the National Cancer Institute, National Institutes of Health, to The University of Texas MD Anderson Cancer Center. Dr. Lin reports funding from Varian, AstraZeneca, and Pfizer for investigator-initiated clinical trials. She receives funding from NCI for unrelated work (R01CA258717 and R01CA249329). The other authors report no proprietary or commercial conflicts of interest with respect to any product mentioned or concept discussed in the present work. |
| Grant Information: | P30 CA016672 United States CA NCI NIH HHS |
| Contributed Indexing: | Keywords: Uterine cancer; brachytherapy; gynecologic cancer; quality of life; radiation; sexual dysfunction; surgery |
| Entry Date(s): | Date Created: 20231101 Date Completed: 20240122 Latest Revision: 20250911 |
| Update Code: | 20260130 |
| DOI: | 10.1016/j.brachy.2023.09.008 |
| PMID: | 37914588 |
| Database: | MEDLINE |
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural