Sickle cell allele HBB-rs334(T) is associated with decreased risk of childhood Burkitt lymphoma in East Africa.
| Title: | Sickle cell allele HBB-rs334(T) is associated with decreased risk of childhood Burkitt lymphoma in East Africa. |
|---|---|
| Authors: | Hong HG; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland, USA.; Gouveia MH; Center for Research on Genomics and Global Health, NHGRI, National Institutes of Health, Bethesda, Maryland, USA.; Ogwang MD; EMBLEM Study, St. Mary's Hospital Lacor, Gulu, Uganda.; EMBLEM Study, African Field Epidemiology Network, Kampala, Uganda.; Kerchan P; EMBLEM Study, African Field Epidemiology Network, Kampala, Uganda.; EMBLEM Study, Kuluva Hospital, Arua, Uganda.; Reynolds SJ; Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.; Tenge CN; EMBLEM Study, Moi University College of Health Sciences, Eldoret, Kenya.; Were PA; EMBLEM Study, Academic Model Providing Access To Healthcare (AMPATH), Eldoret, Kenya.; Kuremu RT; EMBLEM Study, Moi University College of Health Sciences, Eldoret, Kenya.; Wekesa WN; EMBLEM Study, Moi University College of Health Sciences, Eldoret, Kenya.; Masalu N; EMBLEM Study, Bugando Medical Center, Mwanza, Tanzania.; Kawira E; EMBLEM Study, Shirati Health, Education, and Development Foundation, Shirati, Tanzania.; Kinyera T; EMBLEM Study, St. Mary's Hospital Lacor, Gulu, Uganda.; EMBLEM Study, African Field Epidemiology Network, Kampala, Uganda.; Wang X; Sickle Cell Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.; Zhou J; Department of Statistics and Probability, Michigan State University, East Lansing, Michigan, USA.; Leal TP; Lerner Research Institute, Genomic Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, USA.; Otim I; EMBLEM Study, St. Mary's Hospital Lacor, Gulu, Uganda.; EMBLEM Study, African Field Epidemiology Network, Kampala, Uganda.; Legason ID; EMBLEM Study, African Field Epidemiology Network, Kampala, Uganda.; EMBLEM Study, Kuluva Hospital, Arua, Uganda.; Nabalende H; EMBLEM Study, St. Mary's Hospital Lacor, Gulu, Uganda.; EMBLEM Study, African Field Epidemiology Network, Kampala, Uganda.; Dhudha H; EMBLEM Study, Bugando Medical Center, Mwanza, Tanzania.; Mumia M; EMBLEM Study, Academic Model Providing Access To Healthcare (AMPATH), Eldoret, Kenya.; Baker FS; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland, USA.; Okusolubo T; Sickle Cell Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.; Ayers LW; Department of Pathology, The Ohio State University, Columbus, Ohio, USA.; Bhatia K; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland, USA.; Goedert JJ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland, USA.; Woo J; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland, USA.; Manning M; Cancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.; Cole N; Cancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.; Luo W; Cancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.; Hicks B; Cancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.; Chagaluka G; Departments of Pediatrics and Surgery, College of Medicine, University of Malawi, Blantyre, Malawi.; Johnston WT; Epidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, York, UK.; Mutalima N; Epidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, York, UK.; Cancer Epidemiology Unit, University of Oxford, Oxford, UK.; Borgstein E; Departments of Pediatrics and Surgery, College of Medicine, University of Malawi, Blantyre, Malawi.; Liomba GN; Departments of Pediatrics and Surgery, College of Medicine, University of Malawi, Blantyre, Malawi.; Kamiza S; Departments of Pediatrics and Surgery, College of Medicine, University of Malawi, Blantyre, Malawi.; Mkandawire N; Departments of Pediatrics and Surgery, College of Medicine, University of Malawi, Blantyre, Malawi.; Mitambo C; Research Department, Ministry of Health, Lilongwe, Malawi.; Molyneux EM; Departments of Pediatrics and Surgery, College of Medicine, University of Malawi, Blantyre, Malawi.; Newton R; Epidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, York, UK.; Hutchinson A; Cancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.; Yeager M; Cancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.; Adeyemo AA; Center for Research on Genomics and Global Health, NHGRI, National Institutes of Health, Bethesda, Maryland, USA.; Thein SL; Sickle Cell Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.; Rotimi CN; Center for Research on Genomics and Global Health, NHGRI, National Institutes of Health, Bethesda, Maryland, USA.; Chanock SJ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland, USA.; Prokunina-Olsson L; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland, USA.; Mbulaiteye SM; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland, USA. |
| Source: | American journal of hematology [Am J Hematol] 2024 Jan; Vol. 99 (1), pp. 113-123. Date of Electronic Publication: 2023 Nov 27. |
| Publication Type: | Journal Article; Research Support, N.I.H., Intramural; Research Support, U.S. Gov't, P.H.S. |
| Language: | English |
| Journal Info: | Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 7610369 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-8652 (Electronic) Linking ISSN: 03618609 NLM ISO Abbreviation: Am J Hematol Subsets: MEDLINE |
| Imprint Name(s): | Publication: New York Ny : Wiley-Blackwell; Original Publication: New York, Liss. |
| MeSH Terms: | Burkitt Lymphoma*/epidemiology ; Burkitt Lymphoma*/genetics ; Malaria, Falciparum*/epidemiology ; Malaria, Falciparum*/genetics ; Malaria, Falciparum*/complications ; Sickle Cell Trait*/epidemiology ; Sickle Cell Trait*/genetics ; Sickle Cell Trait*/complications ; Malaria*; Nectins/metabolism ; Humans ; Africa, Eastern ; Alleles |
| Abstract: | Burkitt lymphoma (BL) is an aggressive B-cell lymphoma that significantly contributes to childhood cancer burden in sub-Saharan Africa. Plasmodium falciparum, which causes malaria, is geographically associated with BL, but the evidence remains insufficient for causal inference. Inference could be strengthened by demonstrating that mendelian genes known to protect against malaria-such as the sickle cell trait variant, HBB-rs334(T)-also protect against BL. We investigated this hypothesis among 800 BL cases and 3845 controls in four East African countries using genome-scan data to detect polymorphisms in 22 genes known to affect malaria risk. We fit generalized linear mixed models to estimate odds ratios (OR) and 95% confidence intervals (95% CI), controlling for age, sex, country, and ancestry. The ORs of the loci with BL and P. falciparum infection among controls were correlated (Spearman's ρ = 0.37, p = .039). HBB-rs334(T) was associated with lower P. falciparum infection risk among controls (OR = 0.752, 95% CI 0.628-0.9; p = .00189) and BL risk (OR = 0.687, 95% CI 0.533-0.885; p = .0037). ABO-rs8176703(T) was associated with decreased risk of BL (OR = 0.591, 95% CI 0.379-0.992; p = .00271), but not of P. falciparum infection. Our results increase support for the etiological correlation between P. falciparum and BL risk.; (© 2023 Wiley Periodicals LLC. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.) |
| References: | J Infect Dis. 2012 Mar 15;205(6):906-13. (PMID: 22301635); Nature. 1986 Jun 19-25;321(6072):744-50. (PMID: 3713863); S Afr Med J. 2016 Jun 17;106(7):10693. (PMID: 27384372); J Med Genet. 1966 Sep;3(3):177-9. (PMID: 5971054); Circ Res. 2016 Jun 24;119(1):36-40. (PMID: 27151400); Lancet. 1991 Apr 13;337(8746):876-8. (PMID: 1672968); Br J Prev Soc Med. 1970 Feb;24(1):39-41. (PMID: 5435086); PLoS Pathog. 2014 May 29;10(5):e1004170. (PMID: 24874410); EBioMedicine. 2017 Nov;25:58-65. (PMID: 29033373); Nature. 2012 Sep 20;489(7416):443-6. (PMID: 22895189); Int J Cancer. 2008 Mar 15;122(6):1319-23. (PMID: 18000823); Infect Agent Cancer. 2010 Jul 28;5:13. (PMID: 20667138); J Infect Dis. 2012 Nov 15;206(10):1612-21. (PMID: 22966126); Nat Genet. 2013 Oct;45(10):1238-1243. (PMID: 24013639); J Infect Dis. 2016 Oct 1;214(7):1072-80. (PMID: 27481862); Blood. 2013 Aug 1;122(5):629-35. (PMID: 23645841); Immunol Today. 1992 Jun;13(6):198-200. (PMID: 1385707); Leukemia. 2021 Apr;35(4):1209-1213. (PMID: 33051549); Nat Med. 2021 Apr;27(4):653-658. (PMID: 33619371); Proc Natl Acad Sci U S A. 2007 Oct 30;104(44):17471-6. (PMID: 17959777); Infect Immun. 2015 Aug;83(8):3096-103. (PMID: 26015475); Am J Trop Med Hyg. 1976 Jul;25(4):633-6. (PMID: 961985); Diabetologia. 2011 Apr;54(4):783-8. (PMID: 21188353); Trans R Soc Trop Med Hyg. 1999 Feb;93 Suppl 1:59-64. (PMID: 10450428); Histopathology. 2022 Jan;80(2):430-442. (PMID: 33948980); Nature. 2022 Feb;602(7895):106-111. (PMID: 34883497); Science. 1990 Nov 9;250(4982):830-2. (PMID: 2173142); PLoS Med. 2005 Dec;2(12):e340. (PMID: 16259530); N Engl J Med. 2014 May 8;370(19):1799-808. (PMID: 24806160); Nat Rev Dis Primers. 2022 Dec 15;8(1):78. (PMID: 36522349); Lancet Infect Dis. 2012 Jun;12(6):457-68. (PMID: 22445352); Proc Natl Acad Sci U S A. 2023 Jan 10;120(2):e2211055120. (PMID: 36595676); EBioMedicine. 2019 Jan;39:358-368. (PMID: 30579868); Lancet. 2010 May 8;375(9726):1661-3. (PMID: 20452522); Nat Med. 1998 Mar;4(3):358-60. (PMID: 9500614); Blood. 2023 Feb 23;141(8):904-916. (PMID: 36201743); Lancet. 1993 Mar 6;341(8845):612-3. (PMID: 8094840); Int J Cancer. 2020 Feb 15;146(4):953-969. (PMID: 31054214); Lancet Oncol. 2012 Apr;13(4):339-40. (PMID: 22577663); PLoS Genet. 2019 Mar 8;15(3):e1008027. (PMID: 30849090); Sci Rep. 2014 Jan 17;4:3741. (PMID: 24434689); Int J Cancer. 2014 Feb 1;134(3):645-53. (PMID: 23832374); Altern Med Rev. 2003 Aug;8(3):223-46. (PMID: 12946237); Infect Agent Cancer. 2021 Jun 7;16(1):40. (PMID: 34099001); N Engl J Med. 2013 Jan 17;368(3):197-9. (PMID: 23323894); Malar J. 2018 Apr 23;17(1):172. (PMID: 29685152); Lancet Reg Health Eur. 2023 Jan 13;27:100581. (PMID: 37069854); Nat Genet. 2005 Nov;37(11):1253-7. (PMID: 16227994); PLoS One. 2008 Jun 18;3(6):e2505. (PMID: 18560562); PLoS Pathog. 2010 Feb 19;6(2):e1000770. (PMID: 20174609); Blood Adv. 2023 Sep 12;7(17):4962-4965. (PMID: 37171463); Am J Epidemiol. 2012 Oct 1;176 Suppl 7:S175-85. (PMID: 23035141); Nat Genet. 2014 Nov;46(11):1197-204. (PMID: 25261933); Cell. 2015 Aug 13;162(4):727-37. (PMID: 26276629); Malar J. 2018 Jun 20;17(1):240. (PMID: 29925378); J Exp Med. 2001 Jun 18;193(12):1403-12. (PMID: 11413195); Trans R Soc Trop Med Hyg. 1954 Jul;48(4):312-8. (PMID: 13187561); Nat Commun. 2019 Feb 20;10(1):856. (PMID: 30787300); Nat Commun. 2019 Dec 16;10(1):5732. (PMID: 31844061); J Infect Dis. 2016 Mar 15;213(6):985-91. (PMID: 26531246); Gulf J Oncolog. 2018 Sep;1(28):11-16. (PMID: 30344128); J Clin Invest. 1991 Dec;88(6):1963-8. (PMID: 1752955); Comput Struct Biotechnol J. 2022 Apr 09;20:1821-1828. (PMID: 35521552); BMC Med. 2018 Oct 18;16(1):190. (PMID: 30333020); Cancers (Basel). 2021 Apr 02;13(7):. (PMID: 33918470); J Exp Med. 1993 Feb 1;177(2):295-304. (PMID: 8381152); J Infect Dis. 2020 Feb 18;221(5):775-785. (PMID: 31585009); Am J Trop Med Hyg. 1954 Mar;3(2):219-24. (PMID: 13138823); Nat Rev Microbiol. 2014 Dec;12(12):833-40. (PMID: 25329408); Proc Natl Acad Sci U S A. 2005 Apr 5;102(14):5108-13. (PMID: 15792998); Nature. 1978 Aug 24;274(5673):756-61. (PMID: 210392); Trans R Soc Trop Med Hyg. 1999 Feb;93 Suppl 1:15-20. (PMID: 10450421) |
| Grant Information: | Z01HG200362 United States HG NHGRI NIH HHS; Z01 CP010176 United States ImNIH Intramural NIH HHS; Z01 HG200362 United States ImNIH Intramural NIH HHS; MC_UU_00033/1 United Kingdom MRC_ Medical Research Council; United States HH HHS |
| Substance Nomenclature: | 0 (Nectins) |
| Entry Date(s): | Date Created: 20231127 Date Completed: 20231227 Latest Revision: 20250530 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC10872868 |
| DOI: | 10.1002/ajh.27149 |
| PMID: | 38009642 |
| Database: | MEDLINE |
Journal Article; Research Support, N.I.H., Intramural; Research Support, U.S. Gov't, P.H.S.