Polygenic Contributions to Suicidal Thoughts and Behaviors in a Sample Ascertained for Alcohol Use Disorders.
| Title: | Polygenic Contributions to Suicidal Thoughts and Behaviors in a Sample Ascertained for Alcohol Use Disorders. |
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| Authors: | Colbert SMC; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.; Mullins N; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Chan G; Mount Sinai Clinical Intelligence Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Meyers JL; Department of Psychiatry, University of Connecticut, Farmington, CT, USA.; Department of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, Brooklyn, NY, USA.; Schulman J; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Kuperman S; Henri Begleiter Neurodynamics Lab, SUNY Downstate Health Sciences University, Brooklyn, NY, USA.; Lai D; Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA, USA.; Nurnberger J; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.; Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA, USA.; Plawecki MH; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.; Kamarajan C; Department of Psychiatry, University of Connecticut, Farmington, CT, USA.; Department of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, Brooklyn, NY, USA.; Anokhin AP; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.; Bucholz KK; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.; Hesselbrock V; Mount Sinai Clinical Intelligence Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Edenberg HJ; Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA, USA.; Department of Psychiatry and Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA.; Kramer J; Henri Begleiter Neurodynamics Lab, SUNY Downstate Health Sciences University, Brooklyn, NY, USA.; Dick DM; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA.; Porjesz B; Department of Psychiatry, University of Connecticut, Farmington, CT, USA.; Department of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, Brooklyn, NY, USA.; Agrawal A; Department of Psychiatry, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.; Johnson EC; Department of Psychiatry, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA. |
| Source: | Complex psychiatry [Complex Psychiatry] 2023 Jan 18; Vol. 9 (1-4), pp. 11-23. Date of Electronic Publication: 2023 Jan 18 (Print Publication: 2023). |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: S. Karger AG Country of Publication: Switzerland NLM ID: 101764441 Publication Model: eCollection Cited Medium: Print ISSN: 2673-3005 (Print) Linking ISSN: 2673298X NLM ISO Abbreviation: Complex Psychiatry Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: Basel : S. Karger AG, [2020]- |
| Abstract: | Introduction: Suicidal thoughts and behaviors have partially distinct genetic etiologies.; Methods: We used PRS-CS to create polygenic risk scores (PRSs) from GWAS of non-suicidal self-injury, broad-sense self-harm ideation, nonfatal suicide attempt, death by suicide, and depression. Using mixed-effect models, we estimated whether these PRSs were associated with a range of suicidal thoughts and behaviors in the Collaborative Study on the Genetics of Alcoholism (N = 7,526).; Results: All PRSs were significantly associated with suicidal ideation and suicide attempt (betas = 0.08-0.44, false discovery rate [FDR] |
| Competing Interests: | The authors have no conflicts of interest to declare. |
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| Grant Information: | K01 DA051759 United States DA NIDA NIH HHS |
| Contributed Indexing: | Keywords: Depression; Polygenic risk scores; Self-harm; Suicidal ideation; Suicide |
| Entry Date(s): | Date Created: 20231207 Latest Revision: 20231224 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC10697665 |
| DOI: | 10.1159/000529164 |
| PMID: | 38058956 |
| Database: | MEDLINE |
Journal Article