Clinical utility of procalcitonin in implementation of procalcitonin-guided antibiotic stewardship in the South-East Asia and India: evidence and consensus-based recommendations.
| Title: | Clinical utility of procalcitonin in implementation of procalcitonin-guided antibiotic stewardship in the South-East Asia and India: evidence and consensus-based recommendations. |
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| Authors: | Kwa AL; Department of Pharmacy, Singapore General Hospital; Emerging Infectious Diseases Program, Duke-National University of Singapore Medical School, Singapore, Singapore.; Aninda Sidharta BR; Clinical Pathology Laboratory, RSUD Dr. Moewardi Hospital, Central Java, Indonesia.; Son DN; Center for Critical Care Medicine, Bach Mai Hospital; Hanoi Medical University; School of Medicine and Pharmacy, Hanoi National University, Hanoi, Vietnam.; Zirpe K; Department of Neurocritical Care, Ruby Hall Clinic, Grant Medical Foundation, Pune, India.; Periyasamy P; Infectious Diseases Unit, Medical Department, Hospital Canselor Tuanku Muhriz UKM, Kuala Lumpur, Malaysia.; Plongla R; Division of Infectious Diseases, Department of Medicine and Center of Excellence in Antimicrobial Resistance and Stewardship; Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, Thailand.; Swaminathan S; Infectious Diseases, Gleneagles Global Hospitals, Bengaluru, India.; Loho T; Department of Clinical Pathology, Medistra Hospital; Medicine and Health Sciences, Universitas Kristen Krida Wacana, Jakarta, Indonesia.; Van Giap V; Training and Direction of Healthcare Activities Center; Internal Medicine Department, Hanoi Medical University; Vietnam Respiratory Society; Vietnam Society of Sleep Medicine; Respiratory Center, Bach Mai Hospital, Hanoi, Vietnam.; Apisarnthanarak A; Division of Infectious Diseases, Thammasat University Hospital, Pratum Thani, Thailand. |
| Source: | Expert review of anti-infective therapy [Expert Rev Anti Infect Ther] 2024 Jan-Jun; Vol. 22 (1-3), pp. 45-58. Date of Electronic Publication: 2024 Feb 12. |
| Publication Type: | Journal Article; Review; Consensus Statement |
| Language: | English |
| Journal Info: | Publisher: Taylor & Francis Country of Publication: England NLM ID: 101181284 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-8336 (Electronic) Linking ISSN: 14787210 NLM ISO Abbreviation: Expert Rev Anti Infect Ther Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2015- : Abingdon, Oxford : Taylor & Francis; Original Publication: London : Future Drugs Ltd. |
| MeSH Terms: | Sepsis*/drug therapy ; Antimicrobial Stewardship*; Anti-Bacterial Agents/therapeutic use ; Humans ; Procalcitonin ; Biomarkers ; India ; Asia, Eastern |
| Abstract: | Introduction: The South-East Asian (SEA) region and India are highly susceptible to antibiotic resistance, which is caused due to lack of antimicrobial stewardship (AMS) knowledge, uncontrolled use of antibiotics, and poor infection control. Nonadherence to national/local guidelines, developed to combat antimicrobial resistance, is a major concern. A virtual advisory board was conducted to understand the current AMS standards and challenges in its implementation in these regions.; Areas Covered: Procalcitonin (PCT)-guided antibiotic use was discussed in various clinical conditions across initiation, management, and discontinuation stages. Most experts strongly recommended using PCT-driven antibiotic therapy among patients with lower respiratory tract infections, sepsis, and COVID-19. However, additional research is required to understand the optimal use of PCT in patients with organ transplantation and cancer patients with febrile neutropenia. Implementation of the solutions discussed in this review can help improve PCT utilization in guiding AMS in these regions and reducing challenges.; Expert Opinion: Experts strongly support the inclusion of PCT in AMS. They believe that PCT in combination with other clinical data to guide antibiotic therapy may result in more personalized and precise targeted antibiotic treatment. The future of PCT in antibiotic treatment is promising and may result in effective utilization of this biomarker. |
| Contributed Indexing: | Keywords: Antimicrobial stewardship; COVID-19; LRTI; procalcitonin; sepsis |
| Substance Nomenclature: | 0 (Procalcitonin); 0 (Anti-Bacterial Agents); 0 (Biomarkers) |
| Entry Date(s): | Date Created: 20231219 Date Completed: 20240214 Latest Revision: 20260120 |
| Update Code: | 20260130 |
| DOI: | 10.1080/14787210.2023.2296066 |
| PMID: | 38112181 |
| Database: | MEDLINE |
Journal Article; Review; Consensus Statement