Anxiety and Depression in Pediatric-Onset Traumatic Spinal Cord Injury: A Systematic Review.
| Title: | Anxiety and Depression in Pediatric-Onset Traumatic Spinal Cord Injury: A Systematic Review. |
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| Authors: | Mofatteh M; School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK; Neuro International Collaboration (NIC), London, UK. Electronic address: mmofatteh01@qub.ac.uk.; Mashayekhi MS; Division of Neurosurgery, Department of Surgery, The Ottawa Hospital, Ottawa, Ontario, Canada; Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada; Neuro International Collaboration (NIC), Ottawa, Ontario, Canada.; Arfaie S; Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada; Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, USA; Neuro International Collaboration (NIC), Montreal, Quebec, Canada.; Chen Y; Department of Neurology, Foshan Sanshui District People's Hospital, Foshan, China; Neuro International Collaboration (NIC), Foshan, China.; Malhotra AK; Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada; Neuro International Collaboration (NIC), Toronto, Ontario, Canada.; Skandalakis GP; First Department of Neurosurgery, Evangelismos General Hospital, National and Kapodistrian University of Athens, Athens, Greece.; Alvi MA; Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada; Neuro International Collaboration (NIC), Toronto, Ontario, Canada; Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, USA.; Afshari FT; Department of Neurosurgery, Birmingham Children's Hospital, Birmingham, UK.; Meshkat S; Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, Ontario, Canada.; Lin F; Department of Neurosurgery, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde), Foshan, China.; Abdulla E; Department of Neurosurgery, Salmaniya Medical Complex, Manama, Bahrain.; Anand A; B. P. Koirala Institute of Health Sciences, Dharan, Nepal.; Liao X; Department of Neurosurgery, Foshan Sanshui District People's Hospital, Foshan, China; Department of Surgery of Cerebrovascular Diseases, Foshan First People's Hospital, Foshan, China.; McIntyre RS; Neuro International Collaboration (NIC), Toronto, Ontario, Canada; Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada; Brain and Cognition Discovery Foundation, Toronto, Ontario, Canada.; Santaguida C; Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.; Weber MH; Division of Orthopaedic Surgery, McGill University, Montreal, Quebec, Canada; The Research Institute of the McGill University Health Centre, Injury, Repair and Recovery Program, Montreal, Quebec, Canada; Montreal General Hospital, Montreal, Quebec, Canada.; Fehlings MG; Division of Genetics and Development, Krembil Brain Institute, University Health Network, Toronto, Ontario, Canada; Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Division of Neurosurgery and Spinal Program, Department of Surgery, University of Toronto, Toronto, Ontario, Canada. |
| Source: | World neurosurgery [World Neurosurg] 2024 Apr; Vol. 184, pp. 267-282.e5. Date of Electronic Publication: 2023 Dec 23. |
| Publication Type: | Systematic Review; Journal Article |
| Language: | English |
| Journal Info: | Publisher: Elsevier Country of Publication: United States NLM ID: 101528275 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-8769 (Electronic) Linking ISSN: 18788750 NLM ISO Abbreviation: World Neurosurg |
| Imprint Name(s): | Original Publication: New York : Elsevier |
| MeSH Terms: | Spinal Cord Injuries*/psychology ; Spinal Cord Injuries*/epidemiology ; Spinal Cord Injuries*/complications ; Depression*/epidemiology ; Depression*/etiology ; Depression*/psychology ; Anxiety*/epidemiology ; Anxiety*/etiology ; Anxiety*/psychology; Paraplegia/psychology ; Paraplegia/etiology ; Paraplegia/epidemiology ; Quadriplegia/psychology ; Quadriplegia/etiology ; Quality of Life/psychology ; Humans ; Child ; Adolescent ; Child, Preschool ; Age of Onset |
| Abstract: | Background: Traumatic spinal cord injury (TSCI) is a debilitating neurological condition with significant long-term consequences on the mental health and well-being of affected individuals. We aimed to investigate anxiety and depression in individuals with pediatric-onset TSCI.; Methods: PubMed, Scopus, and Web of Science databases were searched from inception to December 20th, 2022 following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines, and studies were included according to the eligibility criteria.; Results: A total of 1013 articles were screened, and 18 studies with 4234 individuals were included in the final review. Of these, 1613 individuals (38.1%) had paraplegia, whereas 1658 (39.2%) had tetraplegia. A total of 1831 participants (43.2%) had complete TSCI, whereas 1024 (24.2%) had incomplete TSCI. The most common etiology of TSCI with 1545 people (36.5%) was motor vehicle accidents. The youngest mean age at the time of injury was 5.92 ± 4.92 years, whereas the oldest was 14.6 ± 2.8 years. Patient Health Questionnaire-9 was the most common psychological assessment used in 9 studies (50.0%). Various risk factors, including pain in 4 studies (22.2%), reduced sleep quality, reduced functional independence, illicit drug use, incomplete injury, hospitalization, reduced quality of life, and duration of injury in 2 (11.1%) studies, each, were associated with elevated anxiety and depression.; Conclusions: Different biopsychosocial risk factors contribute to elevated rates of anxiety and depression among individuals with pediatric-onset TSCI. Individuals at risk of developing anxiety and depression should be identified, and targeted support should be provided. Future large-scale studies with long-term follow-up are required to validate and extend these findings.; (Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.) |
| Contributed Indexing: | Keywords: Anxiety; Depression; Pediatric; Spinal cord injury; Spine; Trauma |
| Entry Date(s): | Date Created: 20231224 Date Completed: 20240807 Latest Revision: 20250626 |
| Update Code: | 20260130 |
| DOI: | 10.1016/j.wneu.2023.12.092 |
| PMID: | 38143027 |
| Database: | MEDLINE |
Systematic Review; Journal Article