The temporal association between social isolation, distress, and psychotic experiences in individuals at clinical high-risk for psychosis.
| Title: | The temporal association between social isolation, distress, and psychotic experiences in individuals at clinical high-risk for psychosis. |
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| Authors: | Akcaoglu Z; Department of Neurosciences, Psychiatry Research Group, Center for Contextual Psychiatry, KU Leuven, Leuven, Belgium.; Vaessen T; Department of Neurosciences, Psychiatry Research Group, Center for Contextual Psychiatry, KU Leuven, Leuven, Belgium.; Department of Psychology, Health & Technology, Faculty of Behavioural, Management and Social Sciences (BMS), University of Twente, Enschede, The Netherlands.; Velthorst E; Department of Research, Community Mental Health Service GGZ Noord-Holland-Noord, Heerhugowaard, The Netherlands.; Lafit G; Department of Neurosciences, Psychiatry Research Group, Center for Contextual Psychiatry, KU Leuven, Leuven, Belgium.; Faculty of Psychology and Educational Sciences, Research Group of Quantitative Psychology and Individual Differences, KU Leuven, Leuven, Belgium.; Achterhof R; Department of Neurosciences, Psychiatry Research Group, Center for Contextual Psychiatry, KU Leuven, Leuven, Belgium.; Nelson B; Centre for Youth Mental Health, University of Melbourne, Parkville, Victoria, Australia.; Orygen, The National Centre of Excellence in Youth Mental Health, Melbourne, Victoria, Australia.; McGorry P; Orygen, The National Centre of Excellence in Youth Mental Health, Melbourne, Victoria, Australia.; Schirmbeck F; Department of Psychiatry, Amsterdam UMC, Location AMC, University of Amsterdam, Amsterdam, North Holland, Netherlands.; Arkin, Institute for Mental Health, Amsterdam, North Holland, The Netherlands.; Morgan C; ESRC Centre for Society and Mental Health and Social Epidemiology Research Group, King's College London, London, London, UK.; Health Service and Population Research Department, Centre for Epidemiology and Public Health, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.; Hartmann J; Orygen, The National Centre of Excellence in Youth Mental Health, Melbourne, Victoria, Australia.; Department of Public Mental Health, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Baden-Württemberg, Germany.; van der Gaag M; Department of Clinical, Neuro and Developmental Psychology, Vrije Universiteit, Amsterdam, North Holland, The Netherlands.; Department of Psychosis Research, Parnassia Psychiatric Institute, The Hague, South Holland, The Netherlands.; de Haan L; Department of Early Psychosis, Amsterdam UMC, Location AMC, Amsterdam, North Holland, The Netherlands.; Valmaggia L; Department of Psychology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; NIHR Biomedical Research Centre, South London and Maudsley NHS Foundation Trust, London, UK.; McGuire P; NIHR Biomedical Research Centre, South London and Maudsley NHS Foundation Trust, London, UK.; Kempton M; Department of Psychosis Studies, Institute of Psychiatry, King's Health Partners, King's College London, London, UK.; Steinhart H; Department of Neurosciences, Psychiatry Research Group, Center for Contextual Psychiatry, KU Leuven, Leuven, Belgium.; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.; Klippel A; Department of Neurosciences, Psychiatry Research Group, Center for Contextual Psychiatry, KU Leuven, Leuven, Belgium.; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.; Department of Lifespan Psychology, Faculty of Psychology, Open University, Heerlen, The Netherlands.; Viechtbauer W; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.; Batink T; Department of Lifespan Psychology, Faculty of Psychology, Open University, Heerlen, The Netherlands.; van Winkel R; Department of Neurosciences, Psychiatry Research Group, Center for Clinical Psychiatry, KU Leuven, Leuven, Belgium.; van Amelsvoort T; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.; Marcelis M; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.; Institute for Mental Health Care Eindhoven (GGzE), Eindhoven, The Netherlands, https://www.ggze.nl/.; van Aubel E; Department of Neurosciences, Psychiatry Research Group, Center for Contextual Psychiatry, KU Leuven, Leuven, Belgium.; Reininghaus U; ESRC Centre for Society and Mental Health and Social Epidemiology Research Group, King's College London, London, London, UK.; Health Service and Population Research Department, Centre for Epidemiology and Public Health, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.; Department of Public Mental Health, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Baden-Württemberg, Germany.; Myin-Germeys I; Department of Neurosciences, Psychiatry Research Group, Center for Contextual Psychiatry, KU Leuven, Leuven, Belgium. |
| Corporate Authors: | EU-GEI High Risk Study |
| Source: | Psychological medicine [Psychol Med] 2024 Jun; Vol. 54 (8), pp. 1684-1692. Date of Electronic Publication: 2024 Jan 05. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Cambridge University Press Country of Publication: England NLM ID: 1254142 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-8978 (Electronic) Linking ISSN: 00332917 NLM ISO Abbreviation: Psychol Med Subsets: MEDLINE |
| Imprint Name(s): | Publication: London : Cambridge University Press; Original Publication: London, British Medical Assn. |
| MeSH Terms: | Psychotic Disorders*/psychology ; Social Isolation*/psychology; Stress, Psychological/psychology ; Humans ; Male ; Female ; Young Adult ; Adolescent ; Adult ; Ecological Momentary Assessment ; Psychological Distress ; Risk Factors |
| Abstract: | Background: Psychotic experiences (PEs) and social isolation (SI) seem related during early stages of psychosis, but the temporal dynamics between the two are not clear. Literature so far suggests a self-perpetuating cycle wherein momentary increases in PEs lead to social withdrawal, which, subsequently, triggers PEs at a next point in time, especially when SI is associated with increased distress. The current study investigated the daily-life temporal associations between SI and PEs, as well as the role of SI-related and general affective distress in individuals at clinical high risk (CHR) for psychosis.; Methods: We used experience sampling methodology in a sample of 137 CHR participants. We analyzed the association between SI, PEs, and distress using time-lagged linear mixed-effects models.; Results: SI did not predict next-moment fluctuations in PEs, or vice versa. Furthermore, although SI-related distress was not predictive of subsequent PEs, general affective distress during SI was a robust predictor of next-moment PEs.; Conclusions: Our results suggest that SI and PEs are not directly related on a moment-to-moment level, but a negative emotional state when alone does contribute to the risk of PEs. These findings highlight the role of affective wellbeing during early-stage psychosis development. |
| Grant Information: | 309767 - INTERACT International ERC_ European Research Council; HEALTH-F2-2010-241909 (Project EU-GEI) Seventh Framework Programme |
| Contributed Indexing: | Keywords: clinical high-risk; distress; experience sampling methodology; negative affect; psychotic experiences; social isolation; solitary stress |
| Entry Date(s): | Date Created: 20240105 Date Completed: 20240528 Latest Revision: 20240528 |
| Update Code: | 20260130 |
| DOI: | 10.1017/S0033291723003598 |
| PMID: | 38179659 |
| Database: | MEDLINE |
Journal Article