Anti-ultraviolet, antibacterial, and biofilm eradication activities against Cutibacterium acnes of melanins and melanin derivatives from Daedaleopsis tricolor and Fomes fomentarius.
| Title: | Anti-ultraviolet, antibacterial, and biofilm eradication activities against Cutibacterium acnes of melanins and melanin derivatives from Daedaleopsis tricolor and Fomes fomentarius. |
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| Authors: | Le TN; Applied Microbiology Laboratory, School of Biotechnology, International University - VNU HCM, Linh Trung ward, Thu Duc, Ho Chi Minh City, Vietnam.; Tran NTH; Applied Microbiology Laboratory, School of Biotechnology, International University - VNU HCM, Linh Trung ward, Thu Duc, Ho Chi Minh City, Vietnam.; Pham VNT; Applied Microbiology Laboratory, School of Biotechnology, International University - VNU HCM, Linh Trung ward, Thu Duc, Ho Chi Minh City, Vietnam.; Van-Thi ND; Applied Microbiology Laboratory, School of Biotechnology, International University - VNU HCM, Linh Trung ward, Thu Duc, Ho Chi Minh City, Vietnam.; Tran HTM; Applied Microbiology Laboratory, School of Biotechnology, International University - VNU HCM, Linh Trung ward, Thu Duc, Ho Chi Minh City, Vietnam.; Research Group Experimental Pharmacology (EFAR), Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information (FASC), Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Laarbeeklaan, Brussels, Belgium. |
| Source: | Frontiers in microbiology [Front Microbiol] 2024 Jan 08; Vol. 14, pp. 1305778. Date of Electronic Publication: 2024 Jan 08 (Print Publication: 2023). |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101548977 Publication Model: eCollection Cited Medium: Print ISSN: 1664-302X (Print) Linking ISSN: 1664302X NLM ISO Abbreviation: Front Microbiol Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: Lausanne : Frontiers Research Foundation |
| Abstract: | Fomes fomentarius and Daedaleopsis tricolor produced significant amounts of water-insoluble melanins, and our previous study successfully enhanced their water solubility by arginine modification. This research aimed to investigate the anti-ultraviolet, antibacterial, and biofilm eradication activities of both the melanins and arginine-modified melanin (melanin derivatives) from these two fungi against an acne-causing bacterium (Cutibacterium acnes). Apart from these, the cytotoxicity of the melanins and melanin derivatives on human skin cells was also evaluated. Melanin derivatives of both two fungi showed significantly higher antibacterial and biofilm eradication activities compared with their original forms. Specifically, the MIC50 values of the melanin derivatives (1,000 μg/mL) are the same as those of erythromycin. Regarding biofilm eradication capacity, the MBEC50 value of D. tricolor melanin derivative (250 μg/mL) was just half of both erythromycin and F. fomentarius melanin derivative. However, it required a 2-fold higher concentration of melanin derivatives than erythromycin to inhibit 90% of the bacterial population and eradicate 90% of their biofilm. Regarding anti-ultraviolet activity, blending melanins or melanin derivatives with a moisturizer/sunscreen enhanced their UV light absorption and the sun protection factor (SPF) values. In addition, melanins showed better effects than their derivatives, and those of D. tricolor were better than F. fomentarius. Remarkably, adding D. tricolor melanin (10%) to a Nivea pure cream could turn this cream into a broad-spectrum sunscreen, with its SPF value and critical wavelength increasing from 7.74 and 338.67 to 14.02 and 377.0, respectively. In addition, adding melanin or a melanin derivative of D. tricolor to an Olay sunscreen enhanced the SPF and the critical wavelength of the sunscreen from 17.25 and 371.67 to 23.82 and 374 and 23.38 and 372, respectively. Notably, melanins and melanin derivatives showed no toxicity in human fibroblasts. The obtained data suggest that arginine modification significantly enhanced the antibacterial and biofilm eradication activities of melanins from D. tricolor and F. fomentarius. However, this is not the case when it comes to their anti-ultraviolet activities. In addition, melanin and melanin derivatives from D. tricolor are potential candidates for anti-acne sunscreen products and are worth further investigation.; (Copyright © 2024 Le, Tran, Pham, Van-Thi and Tran.) |
| Competing Interests: | The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. |
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| Contributed Indexing: | Keywords: Cutibacterium acnes; acne-causing bacterium; arginine-modified melanin; biofilm eradication; fungal melanin; natural antibiotics |
| Entry Date(s): | Date Created: 20240123 Latest Revision: 20241023 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC10803019 |
| DOI: | 10.3389/fmicb.2023.1305778 |
| PMID: | 38260905 |
| Database: | MEDLINE |
Journal Article