Reduction of Chronic Primary Low Back Pain by Spinal Manipulative Therapy is Accompanied by Decreases in Segmental Mechanical Hyperalgesia and Pain Catastrophizing: A Randomized Placebo-controlled Dual-blind Mixed Experimental Trial.
| Title: | Reduction of Chronic Primary Low Back Pain by Spinal Manipulative Therapy is Accompanied by Decreases in Segmental Mechanical Hyperalgesia and Pain Catastrophizing: A Randomized Placebo-controlled Dual-blind Mixed Experimental Trial. |
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| Authors: | Gevers-Montoro C; Department of Anatomy, Université du Québec à Trois-Rivières, Trois- Rivières, Quebec, Canada; CogNAC Research Group, Université du Québec à Trois-Rivières, Trois-Rivières, Quebec, Canada; Madrid College of Chiropractic, RCU María Cristina, San Lorenzo de El Escorial, Madrid, Spain.; Romero-Santiago B; Madrid College of Chiropractic, RCU María Cristina, San Lorenzo de El Escorial, Madrid, Spain.; Medina-García I; Madrid College of Chiropractic, RCU María Cristina, San Lorenzo de El Escorial, Madrid, Spain.; Larranaga-Arzamendi B; Madrid College of Chiropractic, RCU María Cristina, San Lorenzo de El Escorial, Madrid, Spain.; Álvarez-Gálovich L; Instituto Avanzado de Columna, Fundación Jiménez Díaz Hospital, Madrid, Madrid, Spain; Fujitega Research Foundation, Madrid, Madrid, Spain.; Ortega-De Mues A; Fujitega Research Foundation, Madrid, Madrid, Spain.; Piché M; Department of Anatomy, Université du Québec à Trois-Rivières, Trois- Rivières, Quebec, Canada; CogNAC Research Group, Université du Québec à Trois-Rivières, Trois-Rivières, Quebec, Canada. |
| Source: | The journal of pain [J Pain] 2024 Aug; Vol. 25 (8), pp. 104500. Date of Electronic Publication: 2024 Feb 16. |
| Publication Type: | Journal Article; Randomized Controlled Trial |
| Language: | English |
| Journal Info: | Publisher: Churchill Livingstone Country of Publication: United States NLM ID: 100898657 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-8447 (Electronic) Linking ISSN: 15265900 NLM ISO Abbreviation: J Pain Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Philadelphia, PA : Churchill Livingstone, c2000- |
| MeSH Terms: | Low Back Pain*/therapy ; Manipulation, Spinal*/methods ; Hyperalgesia*/therapy ; Chronic Pain*/therapy ; Catastrophization*/therapy; Humans ; Male ; Female ; Adult ; Middle Aged ; Double-Blind Method ; Pain Measurement ; Treatment Outcome |
| Abstract: | Chronic primary low back pain (CPLBP) refers to low back pain that persists over 3 months, that cannot be explained by another chronic condition, and that is associated with emotional distress and disability. Previous studies have shown that spinal manipulative therapy (SMT) is effective in relieving CPLBP, but the underlying mechanisms remain elusive. This randomized placebo-controlled dual-blind mixed experimental trial (NCT05162924) aimed to investigate the efficacy of SMT to improve CPLBP and its underlying mechanisms. Ninety-eight individuals with CPLBP and 49 controls were recruited. Individuals with CPLBP received SMT (n = 49) or a control intervention (n = 49), 12 times over 4 weeks. The primary outcomes were CPLBP intensity (0-100 on a numerical rating scale) and disability (Oswestry Disability Index). Secondary outcomes included pressure pain thresholds in 4 body regions, pain catastrophizing, Central Sensitization Inventory, depressive symptoms, and anxiety scores. Individuals with CPLBP showed widespread mechanical hyperalgesia (P |
| Contributed Indexing: | Keywords: Chronic nonspecific low back pain; chiropractic; nociplastic pain; placebo; spinal manipulation |
| Entry Date(s): | Date Created: 20240218 Date Completed: 20240728 Latest Revision: 20250116 |
| Update Code: | 20260130 |
| DOI: | 10.1016/j.jpain.2024.02.014 |
| PMID: | 38369221 |
| Database: | MEDLINE |
Journal Article; Randomized Controlled Trial