Primary results of the brazilian registry of atherothrombotic disease (NEAT).
| Title: | Primary results of the brazilian registry of atherothrombotic disease (NEAT). |
|---|---|
| Authors: | de Barros E Silva PGM; HCor Research Institute, 250 Abilio Soares Street, São Paulo, SP, 04.005-909, Brazil. pgmelo@hcor.com.br.; Brazilian Clinical Research Institute, São Paulo, Brazil. pgmelo@hcor.com.br.; Hospital Samaritano Paulista, São Paulo, Brazil. pgmelo@hcor.com.br.; Centro Universitário São Camilo, São Paulo, Brazil. pgmelo@hcor.com.br.; do Nascimento CT; Hospital Regional de Presidente Prudente, São Paulo, Brazil.; Pedrosa RP; Procape - Pronto Socorro Cardiológico de Pernambuco - Universidade de Pernambuco, Recife, Brazil.; Nakazone MA; Faculdade de Medicina de São José do Rio Preto, São Paulo, Brazil.; do Nascimento MU; Hospital Regional de Presidente Prudente, São Paulo, Brazil.; de Araújo Melo L; Procape - Pronto Socorro Cardiológico de Pernambuco - Universidade de Pernambuco, Recife, Brazil.; Júnior OLS; Hospital de Base de São José do Rio Preto, São Paulo, Brazil.; Zimmermann SL; Clínica Procardio e Hospital Santa Isabel e Universidade Regional de Blumenau, Santa Catarina, Brazil.; de Melo RMV; Hospital Ana Nery, Bahia, Brazil.; Bergo RR; Hospital Santa Lúcia - Hospital do Coração de Poços de Caldas, Minas Gerais, Brazil.; Precoma DB; Sociedade Hospitalar Angelina Caron - Campina Grande do Sul, Campina Grande Do Sul, Brazil.; Tramujas L; HCor Research Institute, 250 Abilio Soares Street, São Paulo, SP, 04.005-909, Brazil.; Lima EG; InCor HCFMUSP, São Paulo, Brazil.; Dantas JMM; Clínica Cardioped, Espirito Santo, Brazil.; do Amaral Baruzzi AC; Hospital Albert Einstein, São Paulo, Brazil.; Hospital Samaritano Paulista São Paulo, São Paulo, Brazil.; Flumignan RLG; Universidade Federal de São Paulo, São Paulo, Brazil.; de Oliveira Paiva MSM; Instituto Atena de Pesquisa Clínica, Rio Grande Do Norte, Brazil.; Gowdak LHW; InCor HCFMUSP, São Paulo, Brazil.; de Carvalho PN; Centro de Especialidades de Valinhos II, São Paulo, Brazil.; de Figueiredo Neto JA; Universidade Federal Do Maranhão, São Luiz, Brazil.; Silvestre OM; Universidade Federal Do Acre, Acre, Brazil.; Centro de Pesquisa Clínica Silvestre Santé, Acre, Brazil.; Fioranelli A; Santa Casa de São Paulo, São Paulo, Brazil.; Vieira RD'; Hospital E Clínica São Roque, Bahia, Brazil.; Horak ACP; HCor Research Institute, 250 Abilio Soares Street, São Paulo, SP, 04.005-909, Brazil.; Miyada DHK; HCor Research Institute, 250 Abilio Soares Street, São Paulo, SP, 04.005-909, Brazil.; Kojima FCS; HCor Research Institute, 250 Abilio Soares Street, São Paulo, SP, 04.005-909, Brazil.; de Oliveira JS; HCor Research Institute, 250 Abilio Soares Street, São Paulo, SP, 04.005-909, Brazil.; de Oliveira Silva L; HCor Research Institute, 250 Abilio Soares Street, São Paulo, SP, 04.005-909, Brazil.; Pavanello R; HCor Research Institute, 250 Abilio Soares Street, São Paulo, SP, 04.005-909, Brazil.; Ramacciotti E; Santa Casa de São Paulo, São Paulo, Brazil.; Loyola University, Chicago, USA.; Lopes RD; Brazilian Clinical Research Institute, São Paulo, Brazil.; Duke University Medical Center, Durham, NC, USA. |
| Corporate Authors: | NEAT Investigators |
| Source: | Scientific reports [Sci Rep] 2024 Feb 20; Vol. 14 (1), pp. 4222. Date of Electronic Publication: 2024 Feb 20. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: London : Nature Publishing Group, copyright 2011- |
| MeSH Terms: | Coronary Artery Disease*/drug therapy ; Peripheral Arterial Disease*/epidemiology; Brazil/epidemiology ; Rivaroxaban/therapeutic use ; Aged ; Female ; Humans ; Male ; Prospective Studies ; Registries ; Risk Factors ; Middle Aged ; Multicenter Studies as Topic ; Observational Studies as Topic |
| Abstract: | There is limited contemporary prospective real-world evidence of patients with chronic arterial disease in Latin America. The Network to control atherothrombosis (NEAT) registry is a national prospective observational study of patients with known coronary (CAD) and/or peripheral arterial disease (PAD) in Brazil. A total of 2,005 patients were enrolled among 25 sites from September 2020 to March 2022. Patient characteristics, medications and laboratorial data were collected. Primary objective was to assess the proportion of patients who, at the initial visit, were in accordance with good medical practices (domains) for reducing cardiovascular risk in atherothrombotic disease. From the total of patients enrolled, 2 were excluded since they did not meet eligibility criteria. Among the 2,003 subjects included in the analysis, 55.6% had isolated CAD, 28.7% exclusive PAD and 15.7% had both diagnoses. Overall mean age was 66.3 (± 10.5) years and 65.7% were male patients. Regarding evidence-based therapies (EBTs), 4% were not using any antithrombotic drug and only 1.5% were using vascular dose of rivaroxaban (2.5 mg bid). Only 0.3% of the patients satisfied all the domains of secondary prevention, including prescription of EBTs and targets of body-mass index, blood pressure, LDL-cholesterol, and adherence of lifestyle recommendations. The main barrier for prescription of EBTs was medical judgement. Our findings highlight that the contemporary practice does not reflect a comprehensive approach for secondary prevention and had very low incorporation of new therapies in Brazil. Large-scale populational interventions addressing these gaps are warranted to improve the use of evidence-based therapies and reduce the burden of atherothrombotic disease.ClinicalTrials.gov NCT04677725.; (© 2024. The Author(s).) |
| References: | Am J Cardiol. 2021 Jan 1;138:20-25. (PMID: 33065086); Eur Heart J. 2021 Sep 7;42(34):3227-3337. (PMID: 34458905); Arq Bras Cardiol. 2013 Mar;100(3):212-20. (PMID: 23598574); Nat Rev Cardiol. 2022 Jul;19(7):456-474. (PMID: 34997200); Int J Cardiol. 2018 Sep 15;267:13-15. (PMID: 29861104); Circulation. 2017 Mar 21;135(12):e686-e725. (PMID: 27840332); Circulation. 2010 Feb 2;121(4):586-613. (PMID: 20089546); Eur Heart J. 2021 Apr 7;42(14):1289-1367. (PMID: 32860058); Arq Bras Cardiol. 2021 Jan;116(1):108-116. (PMID: 33331461); N Engl J Med. 2020 May 21;382(21):1994-2004. (PMID: 32222135); Am Heart J. 2006 Apr;151(4):786.e1-10. (PMID: 16569533); N Engl J Med. 2017 Oct 5;377(14):1319-1330. (PMID: 28844192); JAMA. 2006 Jan 11;295(2):180-9. (PMID: 16403930); JAMA Cardiol. 2019 May 1;4(5):408-417. (PMID: 30942842); Lancet. 2020 Mar 7;395(10226):795-808. (PMID: 31492503); Clin Cardiol. 2012 Aug;35(8):451-7. (PMID: 22653654); Vasc Med. 1998;3(3):225-9. (PMID: 9892515); Eur Heart J. 2016 Jan 7;37(2):152-60. (PMID: 26330421); Eur Heart J. 2020 Jan 14;41(3):407-477. (PMID: 31504439); BMJ Open Diabetes Res Care. 2021 Jan;9(1):. (PMID: 33414173); Lancet. 1997 May 24;349(9064):1498-504. (PMID: 9167458) |
| Contributed Indexing: | Investigator: CT do Nascimento; RP Pedrosa; MA Nakazone; MU do Nascimento; L de Araújo Melo; OLS Júnior; SL Zimmermann; RMV de Melo; RR Bergo; DB Precoma; L Tramujas; EG Lima; JMM Dantas; AC do Amaral Baruzzi; RLG Flumignan; MSM de Oliveira Paiva; LHW Gowdak; PN de Carvalho; JA de Figueiredo Neto; OM Silvestre; A Fioranelli; RD' Vieira; JAR Fortes; LEF Ritt; LR Requião-Moura; FA Borges; C Bernoche; MA Pompilio; Keywords: Cardiovascular diseases; Guideline adherence; Registries |
| Molecular Sequence: | ClinicalTrials.gov NCT04677725 |
| Substance Nomenclature: | 9NDF7JZ4M3 (Rivaroxaban) |
| Entry Date(s): | Date Created: 20240220 Date Completed: 20240222 Latest Revision: 20240305 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC10879483 |
| DOI: | 10.1038/s41598-024-54516-9 |
| PMID: | 38378735 |
| Database: | MEDLINE |
Journal Article