Diffuse myocardial fibrosis is uncommon in people with perinatally acquired human immunodeficiency virus infection.
| Title: | Diffuse myocardial fibrosis is uncommon in people with perinatally acquired human immunodeficiency virus infection. |
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| Authors: | Williams JL; Division of Pediatric Cardiology, Duke University Medical Center, Durham, NC, USA.; Hung F; Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, NC, USA.; Jenista E; Duke Cardiovascular Magnetic Resonance Center, Duke University Medical Center, Durham, NC, USA.; Division of Cardiology, Duke University Medical Center, Durham, NC, USA.; Barker P; Duke Clinic Research Institute, Durham, NC, USA.; Chakraborty H; Duke Clinic Research Institute, Durham, NC, USA.; Kim R; Department of Radiology, Duke University Medical Center, Durham, NC, USA.; Duke Clinic Research Institute and Duke University School of Medicine, Durham, NC, USA.; McCrary AW; Division of Pediatric Cardiology, Duke University Medical Center, Durham, NC, USA.; Shah SH; Duke Clinic Research Institute and Duke University School of Medicine, Durham, NC, USA.; Department of Medicine, Duke University School of Medicine, Durham, NC, USA.; Thielman N; Division of Infectious Diseases and International Health, Department of Medicine, University Medical Center, Durham, NC, USA.; Bloomfield GS; Department of Medicine, Duke University Medical Center, DUMC Box 3850, 27705, Durham, NC, USA. gerald.bloomfield@duke.edu.; Duke Clinical Research Institute, and Duke Global Health Institute, Duke University, Durham, NC, USA. gerald.bloomfield@duke.edu. |
| Source: | AIDS research and therapy [AIDS Res Ther] 2024 Mar 04; Vol. 21 (1), pp. 13. Date of Electronic Publication: 2024 Mar 04. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: BioMed Central Country of Publication: England NLM ID: 101237921 Publication Model: Electronic Cited Medium: Internet ISSN: 1742-6405 (Electronic) Linking ISSN: 17426405 NLM ISO Abbreviation: AIDS Res Ther Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: [London] : BioMed Central, 2004- |
| MeSH Terms: | HIV Infections*/complications ; HIV Infections*/drug therapy; Adult ; Pregnancy ; Humans ; Female ; Young Adult ; Child ; Male ; Contrast Media ; Prospective Studies ; Gadolinium ; Fibrosis |
| Abstract: | Background: Cardiovascular disease (CVD) remains a leading cause of death in people living with HIV. Myocardial fibrosis is well-described in HIV infection acquired in adulthood. We evaluate the burden of fibrosis by cardiac magnetic resonance in people with perinatal HIV infection.; Methods: Individuals with perinatally acquired HIV (pnHIV) diagnosed before 10 years-old and on antiretroviral treatment for ≥ 6 months were matched with uninfected controls. Patients with significant cardiometabolic co-morbidities and pregnancy were excluded. Diffuse fibrosis was assessed by cardiac magnetic resonance (CMR) with native T1 mapping for calculation of extracellular volume fraction (ECV). Viability was assessed with late gadolinium enhancement. The normality of fibrosis was assessed using the Komogrov-Smirnov test. Fibrosis between the groups was analyzed using a Mann-Whitney U test, as the data was not normally distributed. Statistical significance was defined as a p-valve |
| Comments: | Update of: Res Sq. 2023 Sep 26:rs.3.rs-3370759. doi: 10.21203/rs.3.rs-3370759/v1.. (PMID: 37841862) |
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| Grant Information: | P30 AI064518 United States AI NIAID NIH HHS; R56 HL152803 United States HL NHLBI NIH HHS; R56HL152803 United States HL NHLBI NIH HHS |
| Contributed Indexing: | Keywords: HIV; Myocardial fibrosis; Perinatal infection |
| Substance Nomenclature: | 0 (Contrast Media); AU0V1LM3JT (Gadolinium) |
| Entry Date(s): | Date Created: 20240304 Date Completed: 20240306 Latest Revision: 20240709 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC10913218 |
| DOI: | 10.1186/s12981-024-00598-4 |
| PMID: | 38439093 |
| Database: | MEDLINE |
Journal Article