Seroprevalence of anti-SARS-CoV-2 IgG antibodies in HIV-positive and HIV-negative patients in clinical settings in Douala, Cameroon.
| Title: | Seroprevalence of anti-SARS-CoV-2 IgG antibodies in HIV-positive and HIV-negative patients in clinical settings in Douala, Cameroon. |
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| Authors: | Kwedi Nolna S; Epidemiology Department, Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon.; Capacity for Leadership Excellence and Research (CLEAR), Yaoundé, Cameroon.; Niba M; Capacity for Leadership Excellence and Research (CLEAR), Yaoundé, Cameroon.; Djadda C; Capacity for Leadership Excellence and Research (CLEAR), Yaoundé, Cameroon.; Masumbe Netongo P; Department of Biochemistry, Faculty of Sciences, University of Yaoundé 1, Yaoundé, Cameroon.; Molecular Diagnostics Research Group, Biotechnology Centre-University of Yaounde I, Yaoundé, Cameroon.; School of Science, Navajo Technical University, Crownpoint, NM, United States. |
| Source: | Frontiers in epidemiology [Front Epidemiol] 2023 Aug 14; Vol. 3, pp. 1212220. Date of Electronic Publication: 2023 Aug 14 (Print Publication: 2023). |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 9918419158106676 Publication Model: eCollection Cited Medium: Internet ISSN: 2674-1199 (Electronic) Linking ISSN: 26741199 NLM ISO Abbreviation: Front Epidemiol Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: Lausanne, Switzerland : Frontiers Media S.A., [2021]- |
| Abstract: | Background: The asymptomatic nature of COVID-19 coupled with differential testing are confounders in the assessment of SARS-CoV-2 incidence among people living with HIV (PLWH). As various comorbidities increase the risk of SARS-CoV-2 infection, it is crucial to assess the potential contribution of HIV to the risk of acquiring COVID-19. Our study aimed to compare the anti-SARS-CoV-2 IgG seroprevalence among people living with and without HIV.; Methods: PLWH were enrolled in the HIV units of two health facilities in Douala, Cameroon. Participants were consecutively enrolled, among which 47 were people living with HIV and 31 were HIV-negative patients. SARS-CoV-2 antibody tests were performed on all participants. Overall, medical consultation was conducted. For HIV-positive participants only, viral load, antiretroviral regimen, duration of HIV infection, and duration of antiretroviral treatment were retrieved from medical records.; Results: We found an overall SARS-CoV-2 IgG seroprevalence of 42.31% within the study population, with a SARS-CoV-2 IgG seroprevalence of 44.6% for PLWH and 38.7% among those without HIV infection; no significant statistical difference was observed. Adjusting for sex, HIV status, and BCG vaccination, the odds of previous SARS-CoV-2 infection were higher among married persons in the study population. Sex, BCG vaccination, and HIV status were not found to be associated with SARS-CoV-2 IgG seropositivity.; Conclusions: Our findings support the lack of association between HIV status and susceptibility to SARS-CoV-2 infection. The ARV regimen, suppressed viral load, and Tenofovir boasted ARV regimen might not affect the body's immune response after exposure to SARS-CoV-2 among PLWH. Thus, if HIV is well treated, the susceptibility to COVID-19 in PLWH would be like that of the general population.; (© 2023 Kwedi Nolna, Niba, Djadda and Masumbe Netongo.) |
| Competing Interests: | Authors SN, MN, and CD were consulting for Capacity for Leadership Excellence and Research (CLEAR), Yaoundé–Cameroon. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. |
| References: | Clin Infect Dis. 2021 Oct 5;73(7):e2086-e2094. (PMID: 32803216); JAMA Netw Open. 2021 Feb 1;4(2):e2037069. (PMID: 33533933); J Acquir Immune Defic Syndr. 2015 Apr 15;68(5):495-501. (PMID: 25763783); AIDS. 2020 Oct 1;34(12):1775-1780. (PMID: 32773471); J Med Virol. 2021 Feb;93(2):726-732. (PMID: 32692406); Lancet HIV. 2021 Jun;8(6):e334-e341. (PMID: 33933189); JAMA. 2021 Oct 12;326(14):1400-1409. (PMID: 34473201); Rev Panam Salud Publica. 2021 Jun 21;45:e66. (PMID: 34168682); J Antimicrob Chemother. 2022 Jul 28;77(8):2265-2273. (PMID: 35678461); Ann Intern Med. 2020 Oct 6;173(7):536-541. (PMID: 32589451); Front Immunol. 2023 Mar 08;14:1155855. (PMID: 37090738); JAMA Netw Open. 2021 Jan 4;4(1):e2035057. (PMID: 33410879); Trop Med Int Health. 2021 Jul;26(7):716-719. (PMID: 33733568); Sci Afr. 2021 Jul;12:e00802. (PMID: 34095639); Infection. 2020 Oct;48(5):681-686. (PMID: 32394344); Microbiol Spectr. 2021 Sep 3;9(1):e0029121. (PMID: 34406813); Vaccines (Basel). 2023 Feb 02;11(2):. (PMID: 36851214); Public Health. 2022 Aug;209:36-38. (PMID: 35785597); BMJ Glob Health. 2021 Nov;6(11):. (PMID: 34764148); Eur J Med Res. 2022 Jun 2;27(1):81. (PMID: 35655237); J Acquir Immune Defic Syndr. 2021 Jan 1;86(1):19-21. (PMID: 33044323); Mediterr J Hematol Infect Dis. 2020 Nov 01;12(1):e2020080. (PMID: 33194154); Lancet Infect Dis. 2021 Aug;21(8):1089-1096. (PMID: 33773618); Clin Infect Dis. 2021 Oct 5;73(7):e2005-e2015. (PMID: 32860699); J Environ Public Health. 2021 Oct 22;2021:9081491. (PMID: 34691195); Nat Commun. 2021 Oct 6;12(1):5851. (PMID: 34615863); J Med Virol. 2021 Feb;93(2):641-643. (PMID: 32779740); Trop Med Health. 2022 Dec 27;50(1):98. (PMID: 36575501); Nihon Koshu Eisei Zasshi. 2021 Aug 11;68(8):550-558. (PMID: 33994491); Pan Afr Med J. 2020 Dec 16;37:352. (PMID: 33796166); Lancet Glob Health. 2020 Nov;8(11):e1390-e1398. (PMID: 32979314); BMJ. 2021 Feb 17;372:n334. (PMID: 33597166); Am J Trop Med Hyg. 2021 Jan;104(1):91-94. (PMID: 33185181) |
| Contributed Indexing: | Keywords: COVID-19; Cameroon; HIV; IgG antibodies; SARS-CoV-2 |
| Entry Date(s): | Date Created: 20240308 Latest Revision: 20240309 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC10910930 |
| DOI: | 10.3389/fepid.2023.1212220 |
| PMID: | 38455949 |
| Database: | MEDLINE |
Journal Article