Mines of cytokine: A treasure trove in pulpal and periapical diseases.
| Title: | Mines of cytokine: A treasure trove in pulpal and periapical diseases. |
|---|---|
| Authors: | Chandwani ND; Department of Dentistry, All India Institute of Medical Sciences, Nagpur, Maharashtra, India.; Gedam UD; Department of Dentistry, All India Institute of Medical Sciences, Nagpur, Maharashtra, India.; Deshmukh R; Department of Dentistry, All India Institute of Medical Sciences, Nagpur, Maharashtra, India.; Dakshindas DM; Department of Conservative Dentistry and Endodontics, Government Dental College and Hospital, Nagpur, Maharashtra, India.; Shrigiriwar M; Department of FMT, All India Institute of Medical Sciences, Nagpur, Maharashtra, India. |
| Source: | Journal of conservative dentistry and endodontics [J Conserv Dent Endod] 2024 Mar; Vol. 27 (3), pp. 227-232. Date of Electronic Publication: 2024 Mar 06. |
| Publication Type: | Journal Article; Review |
| Language: | English |
| Journal Info: | Publisher: Wolters Kluwer - Medknow Country of Publication: India NLM ID: 9918697474706676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2950-4708 (Electronic) Linking ISSN: 29504708 NLM ISO Abbreviation: J Conserv Dent Endod Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: [Mumbai] : Wolters Kluwer - Medknow, [2023]- |
| Abstract: | Pulpitis is a special disease of dental pulp. It causes localized inflammation, due to various inflammatory mediators such as cytokines and chemokines. These inflammatory mediators are responsible for various reparative and resorptive processes in the dental pulp. The balance between these processes ultimately determines the viability of the tooth. Due to the important properties of various inflammatory markers, the correlation of cytokinin gene expression in various stages of inflammation becomes necessary to focus on. Several studies in the past have focused on the importance of such correlation to help in diagnostic applications. The nature of these inflammatory mediators can help us in diagnostic evaluation. Several attempts have been made to focus on these associations so that it can assist in making clinical decisions effectively. The data available are vast but are the most neglected topic. This review article briefly outlines and summarizes the importance of various inflammatory mediators such as cytokinin and chemokines in various pathways of pulpal and periapical inflammation in explanatory and diagrammatic forms. Knowledge gained about pulpal inflammatory response may aid in understanding the molecular level of inflammatory pulpal and periapical diseases, which shall modify our future diagnostic modalities. Several medicaments are used in the treatment of minimal to advanced dental caries which leads to periapical infections. Thorough understanding of these medicaments can resolve secondary infection and can improve the prognosis of the treated tooth.; (Copyright: © 2024 Journal of Conservative Dentistry and Endodontics.) |
| Competing Interests: | There are no conflicts of interest. |
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| Contributed Indexing: | Keywords: Chemokines; cytokines; interferons; interleukins; periapical inflammation; pulpal diseases; pulpitis |
| Entry Date(s): | Date Created: 20240418 Latest Revision: 20240425 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC11019815 |
| DOI: | 10.4103/JCDE.JCDE_289_23 |
| PMID: | 38634023 |
| Database: | MEDLINE |
Journal Article; Review