Proteomics discovery in children and young adults with HIV identifies fibrosis, inflammatory, and immune biomarkers associated with myocardial impairment.
| Title: | Proteomics discovery in children and young adults with HIV identifies fibrosis, inflammatory, and immune biomarkers associated with myocardial impairment. |
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| Authors: | Harrington J; Division of Cardiology, Department of Medicine.; Duke Clinical Research Institute.; McCrary AW; Division of Pediatric Cardiology, Department of Pediatrics.; Nguyen M; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, USA.; Nyandiko W; Department of Children Health and Paediatrics, Moi University College of Health Science.; Academic Model Providing Access to Healthcare, Eldoret, Kenya.; Barker PCA; Division of Pediatric Cardiology, Department of Pediatrics.; Koech M; Department of Children Health and Paediatrics, Moi University College of Health Science.; Thielman NM; Duke Global Health Institute, Durham, North Carolina, USA.; Muehlbauer MJ; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, USA.; Shah SH; Division of Cardiology, Department of Medicine.; Duke Clinical Research Institute.; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, USA.; Bloomfield GS; Division of Cardiology, Department of Medicine.; Duke Clinical Research Institute.; Duke Global Health Institute, Durham, North Carolina, USA. |
| Source: | AIDS (London, England) [AIDS] 2024 Jun 01; Vol. 38 (7), pp. 1090-1093. Date of Electronic Publication: 2024 May 01. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Language: | English |
| Journal Info: | Publisher: Lippincott Williams & Wilkins Country of Publication: England NLM ID: 8710219 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-5571 (Electronic) Linking ISSN: 02699370 NLM ISO Abbreviation: AIDS Subsets: MEDLINE |
| Imprint Name(s): | Publication: 1998- : London, England : Lippincott Williams & Wilkins; Original Publication: London : Gower Academic Journals, c1987- |
| MeSH Terms: | HIV Infections*/complications ; Biomarkers*/blood ; Proteomics*; Heart Diseases/blood ; Humans ; Male ; Female ; Child ; Adolescent ; Young Adult ; Adult ; Fibrosis |
| Abstract: | People with HIV are at increased risk of cardiac dysfunction; however, limited tools are available to identify patients at highest risk for future cardiac disease. We performed proteomic profiling using plasma samples from children and young adults with perinatally acquired HIV without clinical cardiac disease, comparing samples from participants with and without an abnormal myocardial performance index (MPI). We identified four proteins independently associated with subclinical cardiac dysfunction: ST2, CA1, EN-RAGE, and VSIG2.; (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.) |
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| Grant Information: | D43 TW009337 United States TW FIC NIH HHS; R56 HL152803 United States HL NHLBI NIH HHS |
| Substance Nomenclature: | 0 (Biomarkers) |
| Entry Date(s): | Date Created: 20240501 Date Completed: 20240501 Latest Revision: 20240708 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC11068093 |
| DOI: | 10.1097/QAD.0000000000003879 |
| PMID: | 38691053 |
| Database: | MEDLINE |
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't