Correlating Severity of Pulmonary Hypertension by Echocardiogram with Mortality in Premature Infants with Bronchopulmonary Dysplasia.
| Title: | Correlating Severity of Pulmonary Hypertension by Echocardiogram with Mortality in Premature Infants with Bronchopulmonary Dysplasia. |
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| Authors: | Torok RD; Division of Pediatric Cardiology, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina.; Gardner RA; Division of Pediatric Pulmonology, Department of Pediatrics, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.; Barker PCA; Division of Pediatric Cardiology, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina.; McCrary AW; Division of Pediatric Cardiology, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina.; Li JS; Division of Pediatric Cardiology, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina.; Department of Pediatrics, Duke Clinical Research Institute, Durham, North Carolina.; Hornik CP; Department of Pediatrics, Duke Clinical Research Institute, Durham, North Carolina.; Division of Pediatric Critical Care, Duke University Medical Center, Durham, North Carolina.; Laughon MM; Division of Neonatal-Perinatal Medicine, Department of Pediatrics, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.; Jackson WM; Division of Neonatal-Perinatal Medicine, Department of Pediatrics, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. |
| Source: | American journal of perinatology [Am J Perinatol] 2024 Dec; Vol. 41 (16), pp. 2206-2213. Date of Electronic Publication: 2024 May 02. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Thieme-Stratton Country of Publication: United States NLM ID: 8405212 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-8785 (Electronic) Linking ISSN: 07351631 NLM ISO Abbreviation: Am J Perinatol Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: New York, NY : Thieme-Stratton, 1983- |
| MeSH Terms: | Bronchopulmonary Dysplasia*/mortality ; Bronchopulmonary Dysplasia*/complications ; Bronchopulmonary Dysplasia*/diagnostic imaging ; Hypertension, Pulmonary*/mortality ; Hypertension, Pulmonary*/diagnostic imaging ; Echocardiography* ; Severity of Illness Index* ; Infant, Extremely Premature*; Humans ; Infant, Newborn ; Female ; Male ; Retrospective Studies ; Gestational Age ; Infant, Premature ; Infant |
| Abstract: | Objective: Bronchopulmonary dysplasia (BPD) is the most common complication of preterm birth. Infants with BPD are at increased risk for pulmonary hypertension (PH). Cardiac catheterization is the gold standard for diagnosing PH, but cardiac catheterization is challenging to perform in small, sick, premature infants. The utility of echocardiography for diagnosing PH and predicting outcomes in extremely premature infants has not been clearly defined. Therefore, we sought to use predefined criteria to diagnose PH by echocardiogram and relate PH severity to mortality in extremely premature infants with BPD.; Study Design: Echocardiograms from 46 infants born ≤28 weeks' postmenstrual age with a diagnosis of BPD were assessed for PH by three pediatric cardiologists using predefined criteria, and survival times among categories of PH patients were compared. A total of 458 echocardiograms were reviewed, and 15 (33%) patients were found to have at least moderate PH. Patients with at least moderate PH had similar demographic characteristics to those with no/mild PH.; Results: Ninety percent of infants without moderate to severe PH survived to hospital discharge, compared with 67% of infants with at least moderate PH (p = 0.048). Patients with severe PH had decreased survival to hospital discharge (38%) compared with moderate (100%) and no/mild PH (90%) groups. Kaplan-Meier survival curves also differed among PH severity groups (Wilcoxon p |
| Competing Interests: | C.P.H. receives salary support for research from National Institute for Child Health and Human Development (NICHD; R13HD102136; RL1HD107784), the National Heart Lung and Blood Institute (NHLBI; R61/R33HL147833), the U.S. Food and Drug Administration (R01-FD006099, PI Laughon; U18-FD006298), the U.S. Government for his work in pediatric clinical pharmacology (Government Contract HHSN275201800003I, PI: Benjamin under the Best Pharmaceuticals for Children Act), the nonprofit Burrhoughs Wellcome Fund, and other sponsors for drug development in adults and children ( https://dcri.org/about-us/conflict-of-interest/ ).W.M.J. received an early career award #14934 from the Thrasher Research Fund. |
| Grant Information: | HHSN275201800003I United States HD NICHD NIH HHS; R34 HL124038 United States HL NHLBI NIH HHS; R01 FD006099 United States FD FDA HHS; R33 HL147833 United States HL NHLBI NIH HHS; United Kingdom WT_ Wellcome Trust; R13 HD102136 United States HD NICHD NIH HHS; RL1 HD107784 United States HD NICHD NIH HHS; U18 FD006298 United States FD FDA HHS |
| Entry Date(s): | Date Created: 20240503 Date Completed: 20241104 Latest Revision: 20251202 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC11530401 |
| DOI: | 10.1055/s-0044-1786544 |
| PMID: | 38698596 |
| Database: | MEDLINE |
Journal Article