Targeting papez circuit for cognitive dysfunction- insights into deep brain stimulation for Alzheimer's disease.
| Title: | Targeting papez circuit for cognitive dysfunction- insights into deep brain stimulation for Alzheimer's disease. |
|---|---|
| Authors: | Rapaka D; DDT College of Medicine, Gaborone, Botswana.; Tebogo MO; School of Pharmacy, Faculty of Health Sciences, University of Botswana, Gaborone, Botswana, P/Bag-0022.; Mathew EM; School of Pharmacy, Faculty of Health Sciences, University of Botswana, Gaborone, Botswana, P/Bag-0022.; Adiukwu PC; DDT College of Medicine, Gaborone, Botswana.; Bitra VR; School of Pharmacy, Faculty of Health Sciences, University of Botswana, Gaborone, Botswana, P/Bag-0022. |
| Source: | Heliyon [Heliyon] 2024 Apr 30; Vol. 10 (9), pp. e30574. Date of Electronic Publication: 2024 Apr 30 (Print Publication: 2024). |
| Publication Type: | Journal Article; Review |
| Language: | English |
| Journal Info: | Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101672560 Publication Model: eCollection Cited Medium: Print ISSN: 2405-8440 (Print) Linking ISSN: 24058440 NLM ISO Abbreviation: Heliyon Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: London : Elsevier Ltd, [2015]- |
| Abstract: | Hippocampus is the most widely studied brain area coupled with impairment of memory in a variety of neurological diseases and Alzheimer's disease (AD). The limbic structures within the Papez circuit have been linked to various aspects of cognition. Unfortunately, the brain regions that include this memory circuit are often ignored in terms of understanding cognitive decline in these diseases. To properly comprehend where cognition problems originate, it is crucial to clarify any aberrant contributions from all components of a specific circuit -on both a local and a global level. The pharmacological treatments currently available are not long lasting. Deep Brain Stimulation (DBS) emerged as a new powerful therapeutic approach for alleviation of the cognitive dysfunctions. Metabolic, functional, electrophysiological, and imaging studies helped to find out the crucial nodes that can be accessible for DBS. Targeting these nodes within the memory circuit produced significant improvement in learning and memory by disrupting abnormal circuit activity and restoring the physiological network. Here, we provide an overview of the neuroanatomy of the circuit of Papez along with the mechanisms and various deep brain stimulation targets of the circuit structures which could be significant for improving cognitive dysfunctions in AD.; (© 2024 The Authors.) |
| Competing Interests: | The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
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| Contributed Indexing: | Keywords: Deep brain stimulation; Entorhinal cortex; Fornix; Hippocampus; Papez circuit; White matter structures |
| Entry Date(s): | Date Created: 20240510 Latest Revision: 20240511 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC11079300 |
| DOI: | 10.1016/j.heliyon.2024.e30574 |
| PMID: | 38726200 |
| Database: | MEDLINE |
Journal Article; Review