Dynamics of Corneal Swelling With Hypoosmolar Riboflavin After Induction During Corneal Collagen Crosslinking in Patients With Progressive Keratoconus.
| Title: | Dynamics of Corneal Swelling With Hypoosmolar Riboflavin After Induction During Corneal Collagen Crosslinking in Patients With Progressive Keratoconus. |
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| Authors: | Syed ZA; Wills Eye Hospital, Cornea Service, Philadelphia, PA; and.; Yu J; Wills Eye Hospital, Cornea Service, Philadelphia, PA; and.; Crespo MA; Wills Eye Hospital, Cornea Service, Philadelphia, PA; and.; Daher ND; Wills Eye Hospital, Cornea Service, Philadelphia, PA; and.; Chang CY; Wills Eye Hospital, Cornea Service, Philadelphia, PA; and.; Glaukos, Medical Affairs, Burlington, MA. |
| Source: | Cornea [Cornea] 2024 Jun 28; Vol. 44 (5), pp. 567-574. Date of Electronic Publication: 2024 Jun 28. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 8216186 Publication Model: Electronic Cited Medium: Internet ISSN: 1536-4798 (Electronic) Linking ISSN: 02773740 NLM ISO Abbreviation: Cornea Subsets: MEDLINE |
| Imprint Name(s): | Publication: Hagerstown, MD : Lippincott Williams & Wilkins; Original Publication: New York, N.Y. : Masson Pub. USA, c1982- |
| MeSH Terms: | Riboflavin*/adverse effects ; Riboflavin*/therapeutic use ; Keratoconus*/drug therapy ; Keratoconus*/metabolism ; Keratoconus*/diagnosis ; Photosensitizing Agents*/adverse effects ; Photosensitizing Agents*/therapeutic use ; Collagen*/metabolism ; Cross-Linking Reagents*/therapeutic use ; Photochemotherapy*/methods ; Corneal Edema*/chemically induced ; Corneal Edema*/diagnosis ; Corneal Edema*/physiopathology; Corneal Stroma/metabolism ; Corneal Stroma/drug effects ; Humans ; Prospective Studies ; Male ; Female ; Adult ; Young Adult ; Ultraviolet Rays ; Corneal Pachymetry ; Adolescent ; Corneal Topography ; Osmolar Concentration ; Visual Acuity |
| Abstract: | Purpose: To evaluate the rate of corneal swelling induced by hypoosmolar riboflavin in patients with progressive keratoconus (KCN) with corneal thickness 17) experienced quicker swelling (14.4 ± 12.8 μm/30 s and 14.9 ± 12.4 μm/30 s, respectively; P < 0.05 for both). A thicker postinduction pachymetry was moderately associated with a faster rate of swelling (rs = 0.389; P = 0.030).; Conclusions: Hypoosmolar riboflavin 0.146% can be safely employed in thinner corneas, allowing for swelling to ≥400 µm for epithelium-off CXL. Associations between swelling rate, KCN severity, and postinduction pachymetry were determined, allowing for a more accurate prediction of procedure time during CXL.; (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.) |
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| Substance Nomenclature: | TLM2976OFR (Riboflavin); 0 (Photosensitizing Agents); 9007-34-5 (Collagen); 0 (Cross-Linking Reagents) |
| Entry Date(s): | Date Created: 20240701 Date Completed: 20250422 Latest Revision: 20250514 |
| Update Code: | 20260130 |
| DOI: | 10.1097/ICO.0000000000003609 |
| PMID: | 38950099 |
| Database: | MEDLINE |
Journal Article