Management of bilateral head and neck paragangliomas at a single-institution across four decades.
| Title: | Management of bilateral head and neck paragangliomas at a single-institution across four decades. |
|---|---|
| Authors: | Bellamkonda N; Department of Otolaryngology - Head and Neck Surgery, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, USA.; Tooker EL; Jefferson Health, Philadelphia, Pennsylvania, USA.; Naumer A; Genetic Counseling Shared Resource, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, USA.; Buchmann LO; Department of Otolaryngology - Head and Neck Surgery, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, USA.; Kohlmann W; Genetic Counseling Shared Resource, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, USA.; McCrary HC; Department of Otolaryngology - Head and Neck Surgery, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, USA.; Patel NS; Department of Otolaryngology - Head and Neck Surgery, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, USA.; Espahbodi M; Department of Otolaryngology - Head and Neck Surgery, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, USA. |
| Source: | Head & neck [Head Neck] 2025 Jan; Vol. 47 (1), pp. 386-393. Date of Electronic Publication: 2024 Aug 21. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural |
| Language: | English |
| Journal Info: | Publisher: John Wiley And Sons Country of Publication: United States NLM ID: 8902541 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0347 (Electronic) Linking ISSN: 10433074 NLM ISO Abbreviation: Head Neck Subsets: MEDLINE |
| Imprint Name(s): | Publication: New York, NY : John Wiley And Sons; Original Publication: New York, NY : J. Wiley, c1989- |
| MeSH Terms: | Head and Neck Neoplasms*/surgery ; Head and Neck Neoplasms*/pathology ; Head and Neck Neoplasms*/therapy; Paraganglioma/surgery ; Paraganglioma/pathology ; Carotid Body Tumor/surgery ; Carotid Body Tumor/pathology ; Humans ; Male ; Female ; Middle Aged ; Retrospective Studies ; Adult ; Aged ; Young Adult ; Treatment Outcome |
| Abstract: | Background: Bilateral head and neck paragangliomas (HNPGLs) require nuanced management to balance tumor control with functional preservation.; Methods: All patients seen at a single-institution for bilateral paraganglioma between 1983 and 2023 were retrospectively reviewed. Demographics, genetic testing results, and tumor characteristics were analyzed and compared to treatment modality and cranial nerve outcomes.; Results: There were 49 patients with 116 tumors (90 carotid body tumors [CBTs], 15 vagal paragangliomas [VPs], and 11 jugular paragangliomas [JPs]). Twenty-six patients had SDH pathologic variants (PV). Surgical management was more commonly utilized in younger patients (OR: 0.97, 95% CI: 0.950-0.992) and for JPs (OR: 9, 95% CI: 1.386-58.443). In surgical cases, CBTs had a lower risk of postoperative cranial nerve deficits compared to JPs and VPs (OR: 0.095, 95% CI: 0.013-0.692).; Conclusions: Younger patients with bilateral HNPGLs, especially those with JP and CBT, are more often treated with surgery. CBTs have lowest risk of cranial nerve deficits after surgery.; (© 2024 The Author(s). Head & Neck published by Wiley Periodicals LLC.) |
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| Grant Information: | P30 CA042014 United States CA NCI NIH HHS; P30CA042014 United States CA NCI NIH HHS |
| Contributed Indexing: | Keywords: SDH; bilateral paraganglioma; carotid body tumor; jugular paraganglioma; vagal paraganglioma |
| Entry Date(s): | Date Created: 20240822 Date Completed: 20241212 Latest Revision: 20260520 |
| Update Code: | 20260520 |
| PubMed Central ID: | PMC11635744 |
| DOI: | 10.1002/hed.27923 |
| PMID: | 39169604 |
| Database: | MEDLINE |
Journal Article; Research Support, N.I.H., Extramural