Risk of cardiovascular disease among head and neck cancer survivors: A population-based matched cohort study.
| Title: | Risk of cardiovascular disease among head and neck cancer survivors: A population-based matched cohort study. |
|---|---|
| Authors: | Keefe K; Department of Otolaryngology, University of Utah School of Medicine, Salt Lake City, UT.; McCrary HC; Department of Otolaryngology, University of Utah School of Medicine, Salt Lake City, UT.; Wei M; Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT.; Mark B; Department of Family and Preventive Medicine, University of Utah School of Medicine, Salt Lake City, UT.; Drejet S; Department of Otolaryngology, University of Utah School of Medicine, Salt Lake City, UT.; Cannon RB; Department of Otolaryngology, University of Utah School of Medicine, Salt Lake City, UT.; Buchmann LO; Department of Otolaryngology, University of Utah School of Medicine, Salt Lake City, UT.; Hunt JP; Department of Otolaryngology, University of Utah School of Medicine, Salt Lake City, UT.; Dodson M; Intermountain Healthcare, Salt Lake City, UT.; Deshmukh V; University of Utah Health Sciences Center, Salt Lake City, UT.; Newman M; University of Utah Health Sciences Center, Salt Lake City, UT.; Monroe MM; Department of Otolaryngology, University of Utah School of Medicine, Salt Lake City, UT.; Hashibe M; Department of Family and Preventive Medicine, University of Utah School of Medicine, Salt Lake City, UT. |
| Source: | Oral oncology [Oral Oncol] 2024 Dec; Vol. 159, pp. 107041. Date of Electronic Publication: 2024 Sep 29. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Language: | English |
| Journal Info: | Publisher: Elsevier Country of Publication: England NLM ID: 9709118 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0593 (Electronic) Linking ISSN: 13688375 NLM ISO Abbreviation: Oral Oncol Subsets: MEDLINE |
| Imprint Name(s): | Publication: Amsterdam : Elsevier; Original Publication: Oxford ; New York : Pergamon, c1997- |
| MeSH Terms: | Head and Neck Neoplasms*/epidemiology ; Head and Neck Neoplasms*/complications ; Cardiovascular Diseases*/epidemiology ; Cardiovascular Diseases*/etiology ; Cancer Survivors*/statistics & numerical data; Utah/epidemiology ; Humans ; Male ; Female ; Middle Aged ; Aged ; Risk Factors ; Cohort Studies ; Adult ; Proportional Hazards Models |
| Abstract: | Background: In the United States, approximately 63,000 Americans develop head and neck cancer (HNC) annually. Our study aims were to investigate cardiovascular complications and risk factors for development of CVD among HNC survivors.; Methods: Utilizing the Utah Populations Database, a total of 1,901 HNC patients diagnosed and 7,796 birth year, sex, and birth state matched individuals from the general population were identified. Multivariate Cox proportional hazard models were used.; Results: Within the first two years after cancer diagnosis, HNC survivors had a higher likelihood of developing cardiovascular disease (CVD). High Charleston Comorbidity Index (CCI) score at baseline (Hazard Ratio (HR) 1.67, 95 % 1.28-2.17), stage II and IV disease (HR 1.80, 95 % 1.29-2.51), age >=65 years old (HR 2.31, 95 % 1.85-2.88), chemotherapy (HR 1.47, 95 % 1.15-1.88) were associated with increased CVD risk.; Conclusions: Compared to the general population, HNC survivors were more likely to develop cardiovascular diseases, particularly if they had the following risk factors: older age, stage II or IV cancer, high baseline CCI score, and chemotherapy were risk factors for development of CVD.; (Copyright © 2024 Elsevier Ltd. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| References: | Circulation. 2016 Feb 2;133(5):484-92. (PMID: 26746177); Ann Oncol. 2014 May;25(5):1059-64. (PMID: 24558023); JAMA Oncol. 2017 Apr 01;3(4):524-548. (PMID: 27918777); Head Neck. 2011 Aug;33(8):1085-91. (PMID: 20886662); Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995 Aug;80(2):178-82. (PMID: 7552882); Am Heart J. 2000 Dec;140(6):878-85. (PMID: 11099991); N Engl J Med. 2010 Jul 1;363(1):24-35. (PMID: 20530316); Front Cardiovasc Med. 2023 Jan 12;9:1024846. (PMID: 36712282); Head Neck. 2017 Mar;39(3):527-532. (PMID: 28032680); CA Cancer J Clin. 2017 Jan;67(1):7-30. (PMID: 28055103); Arch Intern Med. 2001 Apr 9;161(7):996-1002. (PMID: 11295963); J Am Coll Cardiol. 2013 Apr 23;61(16):1736-43. (PMID: 23500290); Cancer. 2014 May 15;120(10):1507-13. (PMID: 24863390); Am J Ther. 2001 Mar-Apr;8(2):117-22. (PMID: 11304665); Lancet. 2013 Jul 27;382(9889):339-52. (PMID: 23727170); Cesk Pediatr. 1989 Apr;44(4):207-10. (PMID: 2736645); JAMA. 1992 Feb 26;267(8):1083-9. (PMID: 1735925); J Natl Cancer Inst. 2007 May 16;99(10):777-89. (PMID: 17505073); Br J Cancer. 2017 May 9;116(10):1366-1373. (PMID: 28399109); Lancet Oncol. 2011 Feb;12(2):153-9. (PMID: 21233014); Cancer Med. 2018 Jan;7(1):87-94. (PMID: 29171183); J Clin Oncol. 2010 Oct 20;28(30):4649-57. (PMID: 20855830); JAMA. 2001 May 9;285(18):2370-5. (PMID: 11343485); Oral Oncol. 2019 Mar;90:54-66. (PMID: 30846177); Arch Intern Med. 2001 Jun 25;161(12):1501-8. (PMID: 11427097); Eur J Cancer. 2017 May;76:93-99. (PMID: 28286287); JAMA Otolaryngol Head Neck Surg. 2023 Aug 1;149(8):717-725. (PMID: 37347472); MMWR Morb Mortal Wkly Rep. 2022 Dec 16;71(50):1583-1588. (PMID: 36520660); J Clin Oncol. 2013 Dec 20;31(36):4550-9. (PMID: 24248688); J Natl Cancer Inst. 2018 Dec 1;110(12):1342-1351. (PMID: 29741696); N Engl J Med. 1995 Nov 16;333(20):1301-7. (PMID: 7566020); Curr Oncol Rep. 2022 Nov;24(11):1579-1592. (PMID: 35796941); Head Neck. 2017 Sep;39(9):1770-1778. (PMID: 28557276); Mayo Clin Proc. 2016 Jan;91(1):81-3. (PMID: 26602599); Lancet. 2004 Sep 11-17;364(9438):937-52. (PMID: 15364185); Circulation. 2012 Aug 21;126(8):934-41. (PMID: 22829023); J Am Coll Cardiol. 1997 Aug;30(2):406-13. (PMID: 9247512); Am J Epidemiol. 2013 Sep 01;178(5):679-90. (PMID: 23817919); Oral Oncol. 2017 Feb;65:8-15. (PMID: 28109473); Am J Otolaryngol. 2017 Jul - Aug;38(4):433-437. (PMID: 28476441) |
| Grant Information: | P30 CA042014 United States CA NCI NIH HHS; R01 RR021746 United States RR NCRR NIH HHS; R03 CA159357 United States CA NCI NIH HHS; R21 CA185811 United States CA NCI NIH HHS |
| Contributed Indexing: | Keywords: Cardiac dysrhythmias; Cardiomyopathy; Cardiovascular disease; Comorbidities; Conduction disorders; Coronary atherosclerosis; Head and neck cancer; Heart valve disease; Risk factors |
| Entry Date(s): | Date Created: 20240930 Date Completed: 20241128 Latest Revision: 20260513 |
| Update Code: | 20260513 |
| PubMed Central ID: | PMC12662656 |
| DOI: | 10.1016/j.oraloncology.2024.107041 |
| PMID: | 39348783 |
| Database: | MEDLINE |
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't