Systematic review of tuberculous meningitis in high-risk populations: mortality and diagnostic disparities.
| Title: | Systematic review of tuberculous meningitis in high-risk populations: mortality and diagnostic disparities. |
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| Authors: | Ieque AL; Postgraduate Program in Health Sciences, State University of Maringá, Maringá, Paraná, 87020-900, Brazil.; Palomo CT; Postgraduate Program in Health Sciences, State University of Maringá, Maringá, Paraná, 87020-900, Brazil.; Castro Moreira D; Postgraduate Program in Health Sciences, State University of Maringá, Maringá, Paraná, 87020-900, Brazil.; Meneguello JE; Postgraduate Program in Bioscience & Physiopathology, State University of Maringá, Maringá, Paraná, 87020-900, Brazil.; Murase LS; Postgraduate Program in Bioscience & Physiopathology, State University of Maringá, Maringá, Paraná, 87020-900, Brazil.; Silva LL; Postgraduate Program in Bioscience & Physiopathology, State University of Maringá, Maringá, Paraná, 87020-900, Brazil.; Baldin VP; Postgraduate Program in Bioscience & Physiopathology, State University of Maringá, Maringá, Paraná, 87020-900, Brazil.; Caleffi-Ferracioli KR; Postgraduate Program in Bioscience & Physiopathology, State University of Maringá, Maringá, Paraná, 87020-900, Brazil.; Laboratory of Medical Bacteriology, Department of Clinical Analysis & Biomedicine, State University of Maringá, Maringá, Paraná, 87020-900, Brazil.; Dias Siqueira VL; Postgraduate Program in Bioscience & Physiopathology, State University of Maringá, Maringá, Paraná, 87020-900, Brazil.; Laboratory of Medical Bacteriology, Department of Clinical Analysis & Biomedicine, State University of Maringá, Maringá, Paraná, 87020-900, Brazil.; Cardoso RF; Postgraduate Program in Health Sciences, State University of Maringá, Maringá, Paraná, 87020-900, Brazil.; Postgraduate Program in Bioscience & Physiopathology, State University of Maringá, Maringá, Paraná, 87020-900, Brazil.; Laboratory of Medical Bacteriology, Department of Clinical Analysis & Biomedicine, State University of Maringá, Maringá, Paraná, 87020-900, Brazil.; Vieira Teixeira JJ; Postgraduate Program in Health Sciences, State University of Maringá, Maringá, Paraná, 87020-900, Brazil.; Postgraduate Program in Bioscience & Physiopathology, State University of Maringá, Maringá, Paraná, 87020-900, Brazil.; Laboratory of Medical Bacteriology, Department of Clinical Analysis & Biomedicine, State University of Maringá, Maringá, Paraná, 87020-900, Brazil.; De Lima Scodro RB; Postgraduate Program in Health Sciences, State University of Maringá, Maringá, Paraná, 87020-900, Brazil.; Laboratory of Medical Bacteriology, Department of Clinical Analysis & Biomedicine, State University of Maringá, Maringá, Paraná, 87020-900, Brazil. |
| Source: | Future microbiology [Future Microbiol] 2025 May-Jun; Vol. 20 (7-9), pp. 559-571. Date of Electronic Publication: 2024 Oct 03. |
| Publication Type: | Systematic Review; Journal Article; Meta-Analysis |
| Language: | English |
| Journal Info: | Publisher: Taylor & Francis Country of Publication: England NLM ID: 101278120 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1746-0921 (Electronic) Linking ISSN: 17460913 NLM ISO Abbreviation: Future Microbiol Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2024- : [Milton Park, Oxfordshire] : Taylor & Francis; Original Publication: London : Future Medicine |
| MeSH Terms: | Tuberculosis, Meningeal*/mortality ; Tuberculosis, Meningeal*/diagnosis ; Tuberculosis, Meningeal*/epidemiology ; Tuberculosis, Meningeal*/drug therapy; Africa/epidemiology ; Mycobacterium tuberculosis/isolation & purification ; Antitubercular Agents/therapeutic use ; Humans ; Risk Factors ; Incidence ; Adult |
| Abstract: | Aim: Tuberculous meningitis (TBM) is one of the most severe clinical forms of tuberculosis (TB). Since epidemiological studies can contribute to TB control, we conducted a review and meta-analysis of epidemiological publications of adults TBM cases in countries with high incidence of TB.Materials & methods: The search resulted in 11,855 articles, in which 21 ultimately were included in our review and 15 in our meta-analysis.Results: TBM mortality was 25% with death rates of 70% in Africa. The review showed different and non-concordant diagnostic techniques and treatment schemes.Conclusion: Adults living in the African region are at high risk of death from TBM, highlighting an urgent need of guidelines to support diagnosis and treatment, and ultimately, to reduce mortality. |
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| Grant Information: | 001 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) |
| Contributed Indexing: | Keywords: Mycobacterium tuberculosis; diagnostic; meningitis; mortality; prevalence; treatment; Local Abstract: [plain-language-summary] Tuberculosis (TB) is a disease that mostly affects the lungs. It can also affect other organs. When TB affects the brain and spinal cord, it is called tuberculous meningitis (TBM). We looked to analyze the traits of the adults with TBM that live in countries with a high number of cases of TB. We searched scientific publications that studied these populations to find information that may help to control the disease. The death rate of TBM was 25%, reaching up to 70% in Africa. We found some disparities regarding diagnosis and treatment. Adults living in Africa have a higher risk of dying from TBM. We need guidelines about the diagnosis and treatment of TBM to help reduce TBM deaths in these countries. |
| Substance Nomenclature: | 0 (Antitubercular Agents) |
| Entry Date(s): | Date Created: 20241003 Date Completed: 20250610 Latest Revision: 20251004 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC12160605 |
| DOI: | 10.1080/17460913.2024.2366604 |
| PMID: | 39360625 |
| Database: | MEDLINE |
Systematic Review; Journal Article; Meta-Analysis