Changes in early HIV/AIDS mortality rates in people initiating antiretroviral treatment between 2013 and 2023: A 10-year multicenter survival study in Senegal.
| Title: | Changes in early HIV/AIDS mortality rates in people initiating antiretroviral treatment between 2013 and 2023: A 10-year multicenter survival study in Senegal. |
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| Authors: | Wembulua BS; Service des Maladies Infectieuses et Tropicales (SMIT), Fann University Hospital, Dakar, Senegal; School of Public Health, Goma University, Goma, Democratic Republic of the Congo. Electronic address: bruliawems@gmail.com.; Cisse VMP; Service des Maladies Infectieuses et Tropicales (SMIT), Fann University Hospital, Dakar, Senegal.; Ka D; Service des Maladies Infectieuses et Tropicales (SMIT), Fann University Hospital, Dakar, Senegal.; Ngom NF; Centre de Traitement Ambulatoire (CTA), Fann University Hospital, Dakar, Senegal.; Mboup A; Centre de Traitement Ambulatoire (CTA), Fann University Hospital, Dakar, Senegal.; Diao I; Centre de Traitement Ambulatoire (CTA), Fann University Hospital, Dakar, Senegal.; Massaly A; Pavillon de Traitment Ambulatoire (PTA), Regional Hospital of Kaolack, Kaolack, Senegal.; Sarr C; Service des Maladies Infectieuses et Tropicales (SMIT), Fann University Hospital, Dakar, Senegal.; Diallo K; Department of Infectious Diseases, Hôpital de la Paix, Ziguinchor, Senegal.; Diallo MB; Service des Maladies Infectieuses et Tropicales (SMIT), Fann University Hospital, Dakar, Senegal.; Diop M; Department of Infectious and Tropical Diseases, Hôpital Principal de Dakar (HPD), Dakar, Senegal.; Ba PS; Department of Infectious and Tropical Diseases, Hôpital Principal de Dakar (HPD), Dakar, Senegal.; Manga NM; Department of Infectious Diseases, Hôpital de la Paix, Ziguinchor, Senegal.; Wembonyama SO; School of Public Health, Goma University, Goma, Democratic Republic of the Congo.; Tsongo ZK; School of Public Health, Goma University, Goma, Democratic Republic of the Congo.; Seydi M; Service des Maladies Infectieuses et Tropicales (SMIT), Fann University Hospital, Dakar, Senegal. |
| Source: | Infectious diseases now [Infect Dis Now] 2024 Dec; Vol. 54 (8), pp. 104990. Date of Electronic Publication: 2024 Oct 05. |
| Publication Type: | Journal Article; Multicenter Study |
| Language: | English |
| Journal Info: | Publisher: Elsevier Masson Country of Publication: France NLM ID: 101775152 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-9919 (Electronic) Linking ISSN: 26669919 NLM ISO Abbreviation: Infect Dis Now Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: [Paris] : Elsevier Masson, [2021]- |
| MeSH Terms: | HIV Infections*/drug therapy ; HIV Infections*/mortality ; Acquired Immunodeficiency Syndrome*/drug therapy ; Acquired Immunodeficiency Syndrome*/mortality; Senegal/epidemiology ; Anti-HIV Agents/therapeutic use ; Humans ; Female ; Male ; Adult ; Middle Aged ; CD4 Lymphocyte Count ; Proportional Hazards Models |
| Abstract: | Background: HIV/AIDS-related early mortality has long been a significant challenge. Subsequent to recent policy changes and treatment advancements, we aimed to assess changes in early mortality rates in 2017-19 and 2020-23 compared to 2013-16.; Methods: This is a 10-year multicenter survival study in people living with human immunodeficiency virus having initiated ART between 2013 and 2023. We used frailty-based competing risk models to estimate adjusted early (6-month and one-year) mortality hazard ratios (HRs) in people living with HIV (PwHIV) having initiated ART in 2013-16 (comparator), 2017-19, and 2020-23.; Results: We enrolled 4006 persons of whom 2281 (56.9 %) were female; median age was 40 years (IQR: 31-50); 635 (15.9 %) were at WHO clinical stage IV and 934 (23.3 %) had a CD4 count |
| Competing Interests: | Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Antiretroviral therapy; HIV mortality rate; Senegal; Survival study; Universal test and treat |
| Substance Nomenclature: | 0 (Anti-HIV Agents) |
| Entry Date(s): | Date Created: 20241007 Date Completed: 20241207 Latest Revision: 20241226 |
| Update Code: | 20260130 |
| DOI: | 10.1016/j.idnow.2024.104990 |
| PMID: | 39374695 |
| Database: | MEDLINE |
Journal Article; Multicenter Study