Impact of hypertension on mortality in patients with ST-elevation myocardial infarction undergoing primary angioplasty: insights from the international multicenter ISACS-STEMI registry.
| Title: | Impact of hypertension on mortality in patients with ST-elevation myocardial infarction undergoing primary angioplasty: insights from the international multicenter ISACS-STEMI registry. |
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| Authors: | De Luca G; Division of Cardiology, AOU Policlinico G. Martino, University of Messina, Messina, Italy and Division of Cardiology, IRCCS Hospital Galeazzi-Sant'Ambrogio, Milan.; Nardin M; Internal Medicine, Department of Medicine, ASST Spedali Civili, Brescia, Italy.; Algowhary M; Division of Cardiology, Assiut University Heart Hospital, Assiut University, Asyut, Egypt.; Uguz B; Division of Cardiology, Bursa City Hospital, Bursa, Turkey.; Oliveira DC; Pronto de Socorro Cardiologico Prof. Luis Tavares, Centro PROCAPE, Federal University of Pernambuco, Recife, Brazil.; Ganyukov V; Department of Heart and Vascular Surgery, State Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russia.; Zimbakov Z; University Clinic for Cardiology, Medical Faculty, Ss' Cyril and Methodius University, Skopje, North Macedonia.; Cercek M; Centre for Intensive Internal Medicine, University Medical Centre, Ljubljana, Slovenia.; Okkels Jensen L; Division of Cardiology, Odense Universitets Hospital, Odense, Denmark.; Loh PH; Department of Cardiology, National University Hospital, Singapore.; Calmac L; Clinic Emergency Hospital of Bucharest, Romania.; Roura I Ferrer G; Interventional Cardiology Unit, Heart Disease Institute. Hospital Universitari de Bellvitge, Spain.; Quadros A; Instituto de Cardiologia do Rio Grande do Sul, Porto Alegre.; Milewski M; Division of Cardiology, Medical University of Silezia, Katowice, Poland.; Scotto D'Uccio F; Division of Cardiology, Ospedale S. Giovanni Bosco, Napoli, Italy.; von Birgelen C; Department of Cardiology, Medisch Spectrum Twente, Thoraxcentrum Twente, Enschede, The Netherlands.; Versaci F; Division of Cardiology, Ospedale Santa Maria Goretti Latina, Italy.; Ten Berg J; Division of Cardiology, St Antonius Hospital, Nieuwegein, The Netherlands.; Casella G; Division of Cardiology, Ospedale Maggiore Bologna, Italy.; Lung AWS; Department of Cardiology, National Heart Center, Singapore.; Kala P; University Hospital Brno, Medical Faculty of Masaryk University Brno, Czech Republic.; Díez Gil JL; H. Universitario y Politécnico La Fe, Valencia, Spain.; Carrillo X; Hospital Germans Triasi Pujol, Badalona, Spain.; Dirksen M; Division of Cardiology, Northwest Clinics Alkmaar, The Netherlands.; Becerra-Munoz VM; Hospital Clínico Universitario Virgen de la Victoria, Málaga, Spain.; Lee MK; Department of Cardiology, Queen Elizabeth Hospital, University of Hong Kong, Hong Kong.; Juzar DA; Department of cardiology and Vascular Medicine, University of Indonesia National Cardiovascular Center 'Harapan Kita', Jakarta.; Moura Joaquim R; Instituto de Cardiologia de Santa Catarina Praia Comprida, São José, Brazil.; Paladino R; Division of Cardiology, Clinica Villa dei Fiori, Acerra, Italy.; Milicic D; Department of Cardiology, University Hospital Centre, University of Zagreb, Zagreb, Croatia.; Davlouros P; Invasive Cardiology and Congenital Heart Disease, Patras University Hospital, Patras, Greece.; Bakraceski N; Center for Cardiovascular Diseases, Ohrid, North Macedonia.; Zilio F; Division of Cardiology, Ospedale Santa Chiara di Trento.; Donazzan L; Division of Cardiology, Ospedale 'S. Maurizio' Bolzano Italy.; Kraaijeveld A; Division of Cardiology, UMC Utrecht, The Netherlands.; Galasso G; Division of Cardiology, Ospedale San Giovanni di Dio e Ruggi d'Aragona, Salerno, Italy.; Lux A; Maastricht University Medical Center, The Netherlands.; Marinucci L; Division of Cardiology, Azienda Ospedaliera 'Ospedali Riuniti Marche Nord', Pesaro.; Guiducci V; Division of Cardiology, AUSL-IRCCS Reggio Emilia.; Menichelli M; Division of Cardiology, Ospedale 'F. Spaziani', Frosinone.; Scoccia A; Division of Cardiology, Ospedale 'Sant'Anna', Ferrara, Italy.; Yamac AH; Department of Cardiology, Hospital Bezmialem Vakif University İstanbul.; Mert KU; Division of Cardiology, Eskisehir Osmangazi University, Faculty of Medicine, Eskisehir, Turkey.; Flores Rios X; Complexo Hospetaliero Universitario La Coruna, La Coruna, Spain.; Kovarnik T; University Hospital Prague, Czech Republic.; Kidawa M; Central Hospital of Medical University of Lodz, Poland.; Moreu J; Division of Cardiology, ComplejoHospitalario de Toledo, Toledo, Spa in.; Flavien V; Division of Cardiology, Center Hospitalier Universitaire de Lille, Lille, France.; Fabris E; Azienda Ospedaliero - Universitaria Ospedali Riuniti Trieste, Italy.; Lozano Martínez-Luengas I; Division of Cardiology, Hospital Cabueñes, Gijon, Spain.; Boccalatte M; Division of Cardiology, Ospedale Santa Maria delle Grazie, Pozzuoli, Italy.; Bosa Ojeda F; Division of cardiology, Hospital Universitario de Canarias, Santa Cruz de Tenerife.; Arellano-Serrano C; Division of Cardiology, Hospital Puerta de Hierro Majadahonda, Spain.; Caiazzo G; Division of Cardiology, Ospedale 'G Moscati', Aversa.; Cirrincione G; Division of Cardiology, Ospedale Civico Arnas, Palermo, Italy.; Kao HL; Cardiology Division, Department of Internal Medicine, National Taiwan University Hospital, Tapei, Taiwan.; Sanchis Forés J; Division of Cardiology, Hospital Clinico Universitario de Valencia, Spain.; Vignali L; Interventional Cardiology Unit, Azienda Ospedaliera Sanitaria, Parma, Italy.; Pereira H; Hospital Garcia de Orta, Cardiology Department, Pragal, Almada, Portugal.; Manzo S; Division of Cardiology, CHU Lariboisière, AP-HP, Paris VII University, INSERM UMRS 942, France.; Ordoñez S; Instituto Cardiovascular de Buenos Aires, Buenos Aires, Argentina.; Arat Özkan A; Cardiology Institute, Istanbul University, Istanbul, Turkey.; Scheller B; Division of Cardiology, Clinical and Experimental Interventional Cardiology, University of Saarland, Germany.; Lehtola H; Division of Cardiology, Oulu University Hospital, Finland.; Teles R; Division of Cardiology, Hospital de Santa Cruz, CHLO - Nova Medical School, CEDOC, Lisbon, Portugal.; Mantis C; Division of Cardiology, Konstantopoulion Hospital, Athens, Greece.; Antti Y; Division of Cardiology, Heart Centre Turku, Finland.; Brum Silveira JA; Division of Cardiology, Hospital de Santo António, Porto, Portugal.; Zoni R; Department of Teaching and Research, Instituto de Cardiología de Corrientes 'Juana F. Cabral', Argentina.; Bessonov I; Tyumen Cardiology Research Center, Russia.; Savonitto S; Division of Cardiology, Ospedale 'A. Manzoni' Lecco, Italy.; Kochiadakis G; Heraklion University Hospital, Crete, Greece.; Alexopulos D; Division of Cardiology, Attikon University Hospital, Athens, Greece.; Uribe CE; Carlos E Uribe, Division of Cardiology, Universidad UPB, Universidad CES.Medellin, Colombia.; Kanakakis J; Division of Cardiology, Alexandra Hospital, Athens, Greece.; Faurie B; Division of Cardiology, Groupe Hospitalier Mutualiste de Grenoble, France.; Gabrielli G; Interventional Cardiolgy Unit IRCCS INRCA, Ancona, Italy.; Gutierrez Barrios A; Division of Cardiology, Hospital Puerta del Mar, Cadiz, Spain.; Bachini JP; Instituto de Cardiologia Integral, Montevideo, Uruguay.; Rocha A; Department of Cardiology and Cardiovascular Interventions, Instituto Nacional de Cirugía Cardíaca, Montevideo, Uruguay.; Tam FC; Department of Cardiology, Queen Mary Hospital, University of Hong Kong, Hong Kong.; Rodriguez A; Division of Cardiology, Otamendi Hospital, Buenos Aires, Argentina.; Lukito AA; Cardiovascular Department Pelita Harapan University/Heart Center Siloam Lippo Village Hospital, Tangerang, Banten, Indonesia.; Saint-Joy V; Center Hospitalier d'Antibes Juan Les Pins, Antibes, France.; Pessah G; Division of Cardiology, Hospiatl Cordoba, Cordoba, Argentina.; Parodi G; Azienda Ospedaliero-Universitaria Sassari, Italy.; Burgadha MA; Division of cardiology, Blida University Hospital, Blida, Algeria.; Kedhi E; Division of Cardiology, Hopital Erasmus, Universitè Libre de Bruxelles.; Lamelas P; Instituto Cardiovascular de Buenos Aires, Buenos Aires, Argentina.; Suryapranata H; Division of Cardiology, Radboud University Medical Center, Nijmegen, The Netherlands.; Verdoia M; Division of Cardiology, Ospedale degli Infermi, ASL Biella, Italy. |
| Source: | Journal of hypertension [J Hypertens] 2025 Feb 01; Vol. 43 (2), pp. 246-254. Date of Electronic Publication: 2024 Oct 11. |
| Publication Type: | Journal Article; Multicenter Study |
| Language: | English |
| Journal Info: | Publisher: Wolters Kluwer Health, Inc Country of Publication: Netherlands NLM ID: 8306882 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-5598 (Electronic) Linking ISSN: 02636352 NLM ISO Abbreviation: J Hypertens Subsets: MEDLINE |
| Imprint Name(s): | Publication: [Alphen aan den Rijn, the Netherlands] : Wolters Kluwer Health, Inc.; Original Publication: London ; New York : Gower Academic Pub., [1983- |
| MeSH Terms: | ST Elevation Myocardial Infarction*/mortality ; ST Elevation Myocardial Infarction*/complications ; ST Elevation Myocardial Infarction*/therapy ; Hypertension*/complications ; Hypertension*/mortality ; COVID-19*/complications ; COVID-19*/mortality ; Registries* ; Percutaneous Coronary Intervention*; Humans ; Male ; Female ; Aged ; Middle Aged ; Retrospective Studies ; Hospital Mortality ; Risk Factors ; SARS-CoV-2 |
| Abstract: | Background: Hypertension is the most prevalent cardiovascular risk factor, with several detrimental effects on the cardiovascular system. Contrasting results have been reported so far on its prognostic role in patients admitted for ST-segment elevation myocardial infarction (STEMI). Therefore, we investigated the impact of hypertension on short-term mortality in a large multicenter contemporary registry of STEMI patients, including patients treated during COVID-19 pandemic.; Methods: The ISACS-STEMI COVID-19 was a retrospective registry that included STEMI patients treated with primary percutaneous coronary intervention (PCI) between March and June of 2019 and 2020 in 109 high-volume primary PCI centers from 4 continents. We collected data on baseline, clinical and procedural characteristics, in-hospital outcome and 30-day mortality. For this analysis patients were grouped according to history of hypertension at admission.; Results: A total of 16083 patients were assessed, including 8813 (54.8%) with history of hypertension. These patients were more often elderly, with a worse cardiovascular risk profile, but were less frequently active smoker. Some procedural differences were observed between the two groups, including lower rate of thrombectomy and use of glycoprotein IIb/IIIa inhibitors or cangrelor but more extensive coronary disease in patients with hypertension. Between patients with and without hypertension, there was no significant difference in SARS-CoV-2 positivity. Hypertensive patients had a significantly higher in-hospital and 30-day mortality, similarly observed in both pre-COVID-19 and COVID-19 era, and confirmed after adjustment for main baseline differences and propensity score (in-hospital mortality: adjusted odds ratio (OR) [95% confidence interval (CI)] =1.673 [1.389-2.014], P |
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| Entry Date(s): | Date Created: 20241024 Date Completed: 20250103 Latest Revision: 20250107 |
| Update Code: | 20260130 |
| DOI: | 10.1097/HJH.0000000000003890 |
| PMID: | 39445586 |
| Database: | MEDLINE |
Journal Article; Multicenter Study