Early single-center experience with an ex vivo organ care system in pediatric heart transplantation.
| Title: | Early single-center experience with an ex vivo organ care system in pediatric heart transplantation. |
|---|---|
| Authors: | Medina CK; Congenital Heart Surgery Research and Training Laboratory, Duke University, Durham, North Carolina; Duke University School of Medicine, Durham, North Carolina.; Aykut B; Congenital Heart Surgery Research and Training Laboratory, Duke University, Durham, North Carolina; Duke Department of Surgery, Duke University Medical Center, Durham, North Carolina.; Parker LE; Congenital Heart Surgery Research and Training Laboratory, Duke University, Durham, North Carolina; Duke University School of Medicine, Durham, North Carolina.; Prabhu NK; Congenital Heart Surgery Research and Training Laboratory, Duke University, Durham, North Carolina; Duke Department of Surgery, Duke University Medical Center, Durham, North Carolina.; Kang L; Congenital Heart Surgery Research and Training Laboratory, Duke University, Durham, North Carolina; Duke Department of Surgery, Duke University Medical Center, Durham, North Carolina.; Beckerman Z; Congenital Heart Surgery Research and Training Laboratory, Duke University, Durham, North Carolina; Duke Department of Surgery, Duke University Medical Center, Durham, North Carolina; Duke Children's Pediatric and Congenital Heart Center, Durham, North Carolina; Division of Thoracic and Cardiovascular Surgery, Duke University Medical Center, Durham, North Carolina.; Schroder JN; Duke Department of Surgery, Duke University Medical Center, Durham, North Carolina; Division of Thoracic and Cardiovascular Surgery, Duke University Medical Center, Durham, North Carolina.; Overbey DM; Congenital Heart Surgery Research and Training Laboratory, Duke University, Durham, North Carolina; Duke Department of Surgery, Duke University Medical Center, Durham, North Carolina; Duke Children's Pediatric and Congenital Heart Center, Durham, North Carolina; Division of Thoracic and Cardiovascular Surgery, Duke University Medical Center, Durham, North Carolina.; Turek JW; Congenital Heart Surgery Research and Training Laboratory, Duke University, Durham, North Carolina; Duke University School of Medicine, Durham, North Carolina; Duke Department of Surgery, Duke University Medical Center, Durham, North Carolina; Duke Children's Pediatric and Congenital Heart Center, Durham, North Carolina; Division of Thoracic and Cardiovascular Surgery, Duke University Medical Center, Durham, North Carolina. Electronic address: joseph.turek@duke.edu. |
| Source: | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation [J Heart Lung Transplant] 2025 Apr; Vol. 44 (4), pp. 545-549. Date of Electronic Publication: 2024 Nov 01. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural |
| Language: | English |
| Journal Info: | Publisher: Elsevier Country of Publication: United States NLM ID: 9102703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-3117 (Electronic) Linking ISSN: 10532498 NLM ISO Abbreviation: J Heart Lung Transplant Subsets: MEDLINE |
| Imprint Name(s): | Publication: 1999- : New York, NY : Elsevier; Original Publication: St. Louis, Mo. : Mosby-Year Book, Inc., c1991- |
| MeSH Terms: | Heart Transplantation*/methods ; Perfusion*/methods ; Organ Preservation*/methods; Humans ; Child ; Adolescent ; Female ; Male ; Retrospective Studies ; Follow-Up Studies ; Tissue Donors |
| Abstract: | Pediatric heart transplantation (HTx) faces challenges such as limited donor availability and the need for complex reconstructions, particularly in patients with congenital anomalies. Ex vivo perfusion offers a promising approach to minimize graft ischemic time and potentially expand the donor pool. We report our single-center experience using the TransMedics Organ Care System (OCS) for ex vivo perfusion in pediatric HTx. From 2020 to 2024, 8 pediatric patients received OCS-perfused donor hearts. The median recipient age was 13 years (range 9-18), and the median weight was 58.8 kg (33.2-127.8). Indications for HTx included dilated cardiomyopathy (n = 4), hypertrophic cardiomyopathy (n = 1), graft vasculopathy (n = 1), and Fontan failure (n = 2). Median OCS time was 273 minutes (195-328), and recipient ischemic time was 85 minutes (64-139). Post-transplant, all patients had normal LV function at discharge. Over a median follow-up of 11.9 months, there were no deaths. These findings suggest that ex vivo perfusion is a valuable technique in pediatric HTx.; (Copyright © 2025 International Society for the Heart and Lung Transplantation. Published by Elsevier Inc. All rights reserved.) |
| Grant Information: | T32 GM145449 United States GM NIGMS NIH HHS |
| Contributed Indexing: | Keywords: congenital heart disease; heart transplantation; organ care system; pediatric heart transplantation; transmedics |
| Entry Date(s): | Date Created: 20241103 Date Completed: 20250425 Latest Revision: 20260513 |
| Update Code: | 20260513 |
| DOI: | 10.1016/j.healun.2024.10.027 |
| PMID: | 39489309 |
| Database: | MEDLINE |
Journal Article; Research Support, N.I.H., Extramural