A Thorough Navigation of miRNA's Blueprint in Crafting Cardiovascular Fate.
| Title: | A Thorough Navigation of miRNA's Blueprint in Crafting Cardiovascular Fate. |
|---|---|
| Authors: | Nazir A; Department of Medicine Oli Health Magazine Organization, Research and Education Kigali Rwanda.; Department of Medicine King Edward Medical University Pakistan.; Uwishema O; Department of Medicine Oli Health Magazine Organization, Research and Education Kigali Rwanda.; Shariff S; Department of Medicine Oli Health Magazine Organization, Research and Education Kigali Rwanda.; Department of Medicine Yerevan State Medical University Yerevan Armenia.; Franco WXG; Department of Medicine Oli Health Magazine Organization, Research and Education Kigali Rwanda.; Department of Medicine University of Guadalajara Guadalajara Mexico.; El Masri N; Department of Medicine Oli Health Magazine Organization, Research and Education Kigali Rwanda.; Faculty of Medicine Beirut Arab University Lebanon.; Ayele ND; Department of Medicine Oli Health Magazine Organization, Research and Education Kigali Rwanda.; Department of Internal Medicine, Faculty of Medicine Wolkite University Wolkite Ethiopia.; Munyangaju I; Department of Medicine Oli Health Magazine Organization, Research and Education Kigali Rwanda.; Barcelona Institute for Global Health-Hospital Clínic Universitat de Barcelona.; Alzain FE; Department of Medicine Oli Health Magazine Organization, Research and Education Kigali Rwanda.; Department of Medicine College of Medicine and General Surgery-Sudan University of Science and Technology.; Wojtara M; Department of Medicine Oli Health Magazine Organization, Research and Education Kigali Rwanda.; Department of Medicine University of Michigan Medical School Ann Arbor Michigan USA. |
| Source: | Health science reports [Health Sci Rep] 2024 Nov 05; Vol. 7 (11), pp. e70136. Date of Electronic Publication: 2024 Nov 05 (Print Publication: 2024). |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: John Wiley and Sons, Inc Country of Publication: United States NLM ID: 101728855 Publication Model: eCollection Cited Medium: Internet ISSN: 2398-8835 (Electronic) Linking ISSN: 23988835 NLM ISO Abbreviation: Health Sci Rep Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: [Hoboken, NJ] : John Wiley and Sons, Inc., [2017]- |
| Abstract: | Introduction: Cardiovascular diseases contribute significantly to global morbidity and mortality. MicroRNAs are crucial in the development and progression of these diseases by regulating gene expression in various cells and tissues. Their roles in conditions like atherosclerosis, heart failure, myocardial infarction, and arrhythmias have been widely researched.; Materials and Methods: The present study provides an overview of existing evidence regarding miRNAs' role in cardiovascular disease pathogenesis. Furthermore, the study examines current state-of-the-art technologies used in the study of miRNAs in cardiovascular disease. As a final point, we examine how miRNAs may serve as disease biomarkers, therapeutic targets, and prognostic indicators.; Results: In cardiology, microRNAs, small noncoding RNA molecules, are crucial to the posttranscriptional regulation of genes. Their role in regulating cardiac cell differentiation and maturation is critical during the development of the heart. They maintain the cardiac function of an adult heart by contributing to its electrical and contractile activity. By binding to messenger RNA molecules, they inhibit protein translation or degrade mRNA. Several cardiovascular diseases are associated with dysregulation of miRNAs, including arrhythmias, hypertension, atherosclerosis, and heart failure. miRNAs can be used as biomarkers to diagnose and predict diseases as well as therapeutic targets. A variety of state-of-the-art technologies have aided researchers in discovering, profiling, and analyzing miRNAs, including microarray analysis, next-generation sequencing, and others.; Conclusion: Developing new diagnostics and therapeutic approaches is becoming more feasible as researchers refine their understanding of miRNA function. Ultimately, this will reduce the burden of cardiovascular disease around the world.; (© 2024 The Author(s). Health Science Reports published by Wiley Periodicals LLC.) |
| Competing Interests: | The authors declare no conflicts of interest. |
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| Contributed Indexing: | Keywords: cardiac diseases; gene expression; miRNA; vascular diseases |
| Entry Date(s): | Date Created: 20241106 Latest Revision: 20241107 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC11535861 |
| DOI: | 10.1002/hsr2.70136 |
| PMID: | 39502130 |
| Database: | MEDLINE |
Journal Article