Evaluation of empirical antibiotic use in diabetic foot infections at a tertiary hospital in Vietnam: A retrospective study.
| Title: | Evaluation of empirical antibiotic use in diabetic foot infections at a tertiary hospital in Vietnam: A retrospective study. |
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| Authors: | Tran NQ; Department of Endocrinology, Faculty of Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.; Department of Endocrinology, University Medical Center Ho Chi Minh City, Ho Chi Minh City, Vietnam.; Dang TND; Department of Clinical Pharmacy, Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.; Department of Pharmacy, University Medical Center Ho Chi Minh City, Ho Chi Minh City, Vietnam.; Vo CTN; Department of Pharmacy, University Medical Center Ho Chi Minh City, Ho Chi Minh City, Vietnam.; Nguyen TTA; Department of Pharmacy, University Medical Center Ho Chi Minh City, Ho Chi Minh City, Vietnam.; Pham QNB; Department of Neurology, University Medical Center Ho Chi Minh City, Ho Chi Minh City, Vietnam.; Do MD; Center for Molecular Biomedicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam. |
| Source: | Medicine [Medicine (Baltimore)] 2024 Nov 15; Vol. 103 (46), pp. e40597. |
| Publication Type: | Journal Article; Observational Study |
| Language: | English |
| Journal Info: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 2985248R Publication Model: Print Cited Medium: Internet ISSN: 1536-5964 (Electronic) Linking ISSN: 00257974 NLM ISO Abbreviation: Medicine (Baltimore) Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Hagerstown, Md : Lippincott Williams & Wilkins |
| MeSH Terms: | Diabetic Foot*/drug therapy ; Anti-Bacterial Agents*/therapeutic use ; Tertiary Care Centers*; Length of Stay/statistics & numerical data ; Humans ; Retrospective Studies ; Male ; Female ; Middle Aged ; Aged ; Vietnam ; Treatment Outcome ; Practice Guidelines as Topic |
| Abstract: | Empirical antibiotic prescription guidelines were developed at the University Medical Center Ho Chi Minh City in 2020, which included recommendations for the use of antibiotics to treat diabetic foot infections (DFIs). This study investigated the treatment outcomes when implementing empirical antibiotic guidelines. This retrospective study included 120 inpatients with DFIs at the Department of Endocrinology, University Medical Center Ho Chi Minh City. This study had 2 periods (before and after implementation of hospital antibiotic guidelines): Period 1 from July 2019 to June 2020 and Period 2 from July 2021 to June 2022, with 60 random patients in each period. Treatment outcomes were assessed as follows: improvement (defined as the absence of fever and a white blood cell count within the normal range) at 72 hours and 7 days; duration of hospitalization; and clinical status at hospital discharge. After implementing empirical antibiotic guidelines, a greater proportion of improvement in the first 7 days of hospitalization (75.0% vs 56.7%, P = .03), and a shorter median duration of hospitalization (12.5 days vs 15.0 days, P = .02) were observed in patients with DFIs. All the patients showed improvement at the time of hospital discharge. The study findings revealed the encouraging effects of implementing empirical antibiotic prescription guidelines for DFI treatment.; (Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.) |
| Competing Interests: | The authors have no funding and conflicts of interest to disclose. |
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| Substance Nomenclature: | 0 (Anti-Bacterial Agents) |
| Entry Date(s): | Date Created: 20241119 Date Completed: 20241119 Latest Revision: 20250128 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC11576029 |
| DOI: | 10.1097/MD.0000000000040597 |
| PMID: | 39560569 |
| Database: | MEDLINE |
Journal Article; Observational Study