Intra-striatal dopaminergic inter-subject covariance in social drinkers and non-treatment-seeking alcohol use disorder participants.
| Title: | Intra-striatal dopaminergic inter-subject covariance in social drinkers and non-treatment-seeking alcohol use disorder participants. |
|---|---|
| Authors: | Chumin EJ; Psychological and Brain Sciences, Indiana University, Bloomington, Indiana, USA.; Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Dzemidzic M; Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Yoder KK; Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana, USA. |
| Source: | Addiction biology [Addict Biol] 2024 Nov; Vol. 29 (11), pp. e70008. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Language: | English |
| Journal Info: | Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 9604935 Publication Model: Print Cited Medium: Internet ISSN: 1369-1600 (Electronic) Linking ISSN: 13556215 NLM ISO Abbreviation: Addict Biol Subsets: MEDLINE |
| Imprint Name(s): | Publication: Hoboken, NJ : Wiley-Blackwell; Original Publication: Abingdon, Oxfordshire, UK ; Cambridge, MA : Carfax, c1996- |
| MeSH Terms: | Alcoholism*/diagnostic imaging ; Alcoholism*/metabolism ; Alcoholism*/physiopathology ; Corpus Striatum*/diagnostic imaging ; Corpus Striatum*/metabolism ; Dopamine*/metabolism ; Positron-Emission Tomography* ; Raclopride*; Humans ; Male ; Adult ; Female ; Middle Aged ; Benzamides ; Alcohol Drinking ; Young Adult ; Case-Control Studies ; Pyrrolidines |
| Abstract: | One of the neurobiological correlates of alcohol use disorder (AUD) is the disruption of striatal dopaminergic function. Although regional differences in dopamine (DA) tone/function have been well studied, interregional relationships (represented as inter-subject covariance) have not been investigated and may offer a novel avenue for understanding DA tone. Positron emission tomography (PET) data with [11C]raclopride in 22 social drinking controls and 17 AUD participants were used to generate group-level striatal covariance (partial Pearson correlation) networks, which were compared edgewise as well as on global network metrics and community structure. An exploratory analysis examined the impact of tobacco cigarette use status. Striatal covariance was validated in an independent publicly available [18F]fallypride PET sample of healthy volunteers. Striatal covariance of control participants from both data sets showed a clear bipartition of the network into two distinct communities, one in the anterior and another in the posterior striatum. This organization was disrupted in the AUD participants' network, which showed significantly lower network metrics compared with the control participants' network. Stratification by cigarette use suggests differential consequences on group covariance networks. This work demonstrates that network neuroscience can quantify group differences in striatal DA and that its interregional interactions offer new insight into the consequences of AUD.; (© 2024 The Author(s). Addiction Biology published by John Wiley & Sons Ltd on behalf of Society for the Study of Addiction.) |
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| Grant Information: | R01 AA01835402 National Institute of Alcohol Abuse and Alcoholism; Indiana University Pervasive Technology Institute; T32 AA07462 National Institute of Alcohol Abuse and Alcoholism; L30 AG089730 United States AG NIA NIH HHS; F31 AA025518 United States AA NIAAA NIH HHS; T32 AA007462 United States AA NIAAA NIH HHS; Lilly Endowment; R21 AA02265002 National Institute of Alcohol Abuse and Alcoholism; Indiana METACyt Initiative |
| Contributed Indexing: | Keywords: PET; covariance networks; dopamine; network neuroscience; striatum |
| Substance Nomenclature: | VTD58H1Z2X (Dopamine); 430K3SOZ7G (Raclopride); 0 (Benzamides); G9FWZ369GX (fallypride); 0 (Pyrrolidines) |
| Entry Date(s): | Date Created: 20241122 Date Completed: 20241122 Latest Revision: 20260306 |
| Update Code: | 20260306 |
| PubMed Central ID: | PMC11583815 |
| DOI: | 10.1111/adb.70008 |
| PMID: | 39576234 |
| Database: | MEDLINE |
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't