Seroprevalence and hematological profile of dengue among healthy inhabitants of Mayo Kebbi province: South of Tchad.
| Title: | Seroprevalence and hematological profile of dengue among healthy inhabitants of Mayo Kebbi province: South of Tchad. |
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| Authors: | Djibrine MB; Molecular Diagnostics Research Group, Biotechnology Center, University of Yaoundé 1, Cameroon.; Department of Microbiology, Faculty of Science, University of Yaoundé 1, Cameroon.; Ngum NL; Molecular Diagnostics Research Group, Biotechnology Center, University of Yaoundé 1, Cameroon.; Department of Biochemistry, Faculty of Medicine and Biomedical Science, University of Yaoundé 1, Cameroon.; Institute of Medicine and Medicinal Plants Studies, IMPM, Yaoundé, Cameroon.; Maurice B; Department of Microbiology, Faculty of Science, University of Yaoundé 1, Cameroon.; Chedjou JPK; Department of Biochemistry, Faculty of Science, University of Buea, Cameroon.; Netongo PM; Molecular Diagnostics Research Group, Biotechnology Center, University of Yaoundé 1, Cameroon.; Department of Biochemistry, Faculty of Science, University of Yaoundé 1, Cameroon. |
| Source: | Journal of family medicine and primary care [J Family Med Prim Care] 2024 Oct; Vol. 13 (10), pp. 4263-4269. Date of Electronic Publication: 2024 Oct 18. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Medknow Country of Publication: India NLM ID: 101610082 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2249-4863 (Print) Linking ISSN: 22494863 NLM ISO Abbreviation: J Family Med Prim Care Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: Mumbai : Medknow |
| Abstract: | Introduction: Dengue is one of the most serious and rapidly spreading major mosquito borne diseases in the world. Despite many acute febrile illnesses in Tchad, the burden of illness due to dengue in the country is largely unknown. Hence, the present study aimed to determine the seroprevalence of dengue viral (DENV) infection and its association with hematological parameters.; Method: A cross sectional study was carried out in Bongor Provincial Hospital. Blood samples were collected from each participant and were used to determine the hematological profile and to diagnose the presence of DENV infection. A total of 130 participants were enrolled in the study. Among these, 114 (87.7%) were diagnosed positive for DENV infection.; Results: The majority of the positive cases were of the age group 21 to 40 years old. Leukocytosis was the most common hematological parameter affecting 120 (92.3%) of them followed by anemia and thrombocytopenia affecting 69 (53.1%) and 16 (12.3%) of them, respectively, and then lymphocytosis affecting 5 (3.8%) of them. No case of leukopenia was recorded.; Discussion: The seroprevalence rate among participants suggests that the dengue virus is in circulation in Mayo Kebbi province: south of Tchad. The abnormal hematological parameters may contribute to the severity of the infection like the incidence of bleeding in the case of thrombocytopenia.; (Copyright: © 2024 Journal of Family Medicine and Primary Care.) |
| Competing Interests: | There are no conflicts of interest. |
| References: | Emerg Infect Dis. 2007 May;13(5):768-71. (PMID: 17553262); Rev Soc Bras Med Trop. 2021 Jan 29;54:e05192020. (PMID: 33533817); Adv Biomed Res. 2015 Jan 30;4:26. (PMID: 25709991); Pan Afr Med J. 2018 Nov 13;31:177. (PMID: 31086629); Emerg Infect Dis. 2011 Aug;17(8):1349-54. (PMID: 21801609); Cell Mol Life Sci. 2010 Aug;67(16):2773-86. (PMID: 20372965); PLoS Negl Trop Dis. 2018 May 31;12(5):e0006430. (PMID: 29852020); PLoS Negl Trop Dis. 2013;7(2):e2055. (PMID: 23437406); Res Rep Trop Med. 2019 Aug 28;10:129-136. (PMID: 31695553); J Ayub Med Coll Abbottabad. 2012 Jan-Mar;24(1):3-6. (PMID: 23855082); Infect Dis Poverty. 2018 Jan 16;7(1):1. (PMID: 29335021); Int J Infect Dis. 2023 Sep;134:292-298. (PMID: 37463631); Med Vet Entomol. 2010 Jun;24(2):132-41. (PMID: 20408956); Front Cell Infect Microbiol. 2017 Jul 25;7:336. (PMID: 28791258); Jpn J Infect Dis. 2015;68(1):55-9. (PMID: 25420658); Annu Rev Microbiol. 2008;62:71-92. (PMID: 18429680); J Infect Dev Ctries. 2012 Jul 23;6(7):551-4. (PMID: 22842941); Blood. 2015 Jul 16;126(3):378-85. (PMID: 25943787); Pak J Med Sci. 2013 Jan;29(1):115-8. (PMID: 24353520); J Clin Diagn Res. 2013 Sep;7(9):1917-20. (PMID: 24179897); Front Cell Infect Microbiol. 2017 Jul 12;7:317. (PMID: 28748176); Comp Immunol Microbiol Infect Dis. 2004 Sep;27(5):319-30. (PMID: 15225982); BMC Infect Dis. 2018 Dec 4;18(1):616. (PMID: 30514223); Infect Dis Rep. 2012 Jan 03;4(1):e5. (PMID: 24470935); Expert Rev Anti Infect Ther. 2015;13(12):1441-56. (PMID: 26536064); PLOS Glob Public Health. 2023 Dec 15;3(12):e0002598. (PMID: 38100392) |
| Contributed Indexing: | Keywords: Dengue; hematological profile; leukopenia; seroprevalence; thrombocytopenia |
| Entry Date(s): | Date Created: 20241204 Latest Revision: 20241205 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC11610836 |
| DOI: | 10.4103/jfmpc.jfmpc_103_24 |
| PMID: | 39629398 |
| Database: | MEDLINE |
Journal Article