Reflexive eye saccadic parameters in Parkinson's disease.
| Title: | Reflexive eye saccadic parameters in Parkinson's disease. |
|---|---|
| Authors: | Pah ND; School of Engineering, RMIT University, Melbourne, VIC, Australia.; Electrical Engineering, Universitas Surabaya, Surabaya, Indonesia.; Ngo QC; School of Engineering, RMIT University, Melbourne, VIC, Australia.; McConnell N; Goulburn Valley Health, Shepperton, VIC, Australia.; Polus B; School of Engineering, RMIT University, Melbourne, VIC, Australia.; Kempster P; Department of Neurology, Monash Health, Clayton, VIC, Australia.; Department of Medicine, Sub-Faculty of Clinical and Molecular Medicine, Monash University, Clayton, VIC, Australia.; Bhattacharya A; Goulburn Valley Health, Shepperton, VIC, Australia.; Raghav S; Department of Neurology, Monash Health, Clayton, VIC, Australia.; Kumar DK; School of Engineering, RMIT University, Melbourne, VIC, Australia. |
| Source: | Frontiers in medical technology [Front Med Technol] 2024 Nov 25; Vol. 6, pp. 1477502. Date of Electronic Publication: 2024 Nov 25 (Print Publication: 2024). |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Frontiers Country of Publication: Switzerland NLM ID: 101772626 Publication Model: eCollection Cited Medium: Internet ISSN: 2673-3129 (Electronic) Linking ISSN: 26733129 NLM ISO Abbreviation: Front Med Technol Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: Lausanne, Switzerland : Frontiers, [2019]- |
| Abstract: | Introduction: Abnormal reactive saccade, with reduced saccadic gain, impaired smooth pursuit, and unwarranted reactions are clinically used to assess people with Parkinson's disease (PwPD). However, there are inconsistent findings related to other saccade parameters such as latency and transition times. This study aimed to identify differences in the reflexive saccade parameters of early stage PwPD and aged-matched control (AMC).; Methods: In this observational study, the reactive eye-gaze was recorded for 70 participants (42 PwPD) and parameters of reflexive saccades and eye-gaze fluctuations were extracted. These parameters were then statistically analyzed using the Mann-Whitney INLINEMATH -test.; Results: Results showed that PwPD had significantly shorter latency than AMC for reflexive saccadic movement away from the center of the screen. The overshoot as a fraction of the screen width, a measure of the inaccuracy in reaching the target, was also significantly higher for PwPD. PwPD had greater horizontal and vertical eye gaze fluctuation with a steady target. The numbers of invalid saccades, i.e., when the gaze goes in the opposite direction from the target movement or is considered anticipatory, were similar for both groups; PwPD with 33.43% and AMC with 25.71%.; Discussion: This study shows that there are significant differences in the reflexive saccade of PwPD and AMC measured using an inexpensive eye-tracking device. The presence of invalid saccade trials, and differences between towards and away from screen center, both of which were not considered in earlier studies, may explain the discrepancies between earlier studies. The outcome of this study has the potential to be made a device that would assist neurologists in the assessment of PwPD.; (© 2024 Pah, Ngo, McConnell, Polus, Kempster, Bhattacharya, Raghav and Kumar.) |
| Competing Interests: | The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. |
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| Contributed Indexing: | Keywords: Parkinson’s disease; eye gaze; latency; reflexive saccade; saccadic |
| Entry Date(s): | Date Created: 20241210 Latest Revision: 20241211 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC11625542 |
| DOI: | 10.3389/fmedt.2024.1477502 |
| PMID: | 39654658 |
| Database: | MEDLINE |
Journal Article