MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration.
| Title: | MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration. |
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| Authors: | Zdouc MM; Bioinformatics Group, Wageningen University & Research, Droevendaalsesteeg 1, 6708 PB Wageningen, The Netherlands.; Blin K; The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Building 220, Søltofts Plads, 2800 Kongens Lyngby, Denmark.; Louwen NLL; Bioinformatics Group, Wageningen University & Research, Droevendaalsesteeg 1, 6708 PB Wageningen, The Netherlands.; Navarro J; Bioinformatics Group, Wageningen University & Research, Droevendaalsesteeg 1, 6708 PB Wageningen, The Netherlands.; Loureiro C; Bioinformatics Group, Wageningen University & Research, Droevendaalsesteeg 1, 6708 PB Wageningen, The Netherlands.; Bader CD; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Campus E8.1, 66123 Saarbrücken, Germany.; Bailey CB; School of Chemistry, Chemistry Building, University of Sydney, Eastern Ave, Camperdown NSW 2050, Sydney, New South Wales, Australia.; Barra L; Department of Chemistry, University of Konstanz, Universitätsstraße 10, 78464 Konstanz, Germany.; Booth TJ; The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Building 220, Søltofts Plads, 2800 Kongens Lyngby, Denmark.; Bozhüyük KAJ; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Campus E8.1, 66123 Saarbrücken, Germany.; Myria Biosciences AG, Tech Park Basel, Hochbergstrasse 60C, 4057 Basel, Switzerland.; Cediel-Becerra JDD; Department of Microbiology and Cell Science, University of Florida, 1355 Museum Drive, Gainesville, Florida, 32611, USA.; Charlop-Powers Z; Ginkgo Bioworks, 27 Drydock Avenue, 8th Floor, Boston, MA 02210, USA.; Chevrette MG; Department of Microbiology and Cell Science, University of Florida, 1355 Museum Drive, Gainesville, Florida, 32611, USA.; University of Florida Genetics Institute, University of Florida, 2033 Mowry Rd, Gainesville, FL 32611, USA.; Chooi YH; School of Molecular Sciences, University of Western Australia, 35 Stirling Highway, Perth 6009, Australia.; D'Agostino PM; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Campus E8.1, 66123 Saarbrücken, Germany.; Chair of Technical Biochemistry, Technical University of Dresden, Bergstraße 66, 01069 Dresden, Germany.; de Rond T; School of Chemical Sciences, University of Auckland, 23 Symonds St, Auckland 1010, New Zealand.; Del Pup E; Bioinformatics Group, Wageningen University & Research, Droevendaalsesteeg 1, 6708 PB Wageningen, The Netherlands.; Duncan KR; Newcastle University, Biosciences Institute, Catherine Cookson Building, Newcastle upon Tyne, NE2 4HH, UK.; Gu W; Sutro Biopharma, 111 Oyster Point Blvd, South San Francisco, CA, 94080, USA.; Hanif N; Department of Chemistry, Faculty of Mathematics and Natural Sciences, IPB University, Gedung Kimia Wing 1 Lantai 3, Jalan Tanjung Kampus IPB Dramaga, Bogor, Jawa Barat 16680, Indonesia.; Helfrich EJN; Institute for Molecular Bio Science, Goethe University Frankfurt, Max-von-Laue Strasse 9, 60438 Frankfurt am Main, Germany.; LOEWE Center for Translational Biodiversity Genomics (TBG), Senckenberganlage 25, 60325 Frankfurt am Main, Germany.; Senckenberg Society for Nature Research, Senckenberganlage 25, 60325 Frankfurt am Main, Germany.; Jenner M; Department of Chemistry, University of Warwick, Gibbet Hill Rd, Coventry, CV4 7AL, UK.; Warwick Integrative Synthetic Biology Centre (WISB), University of Warwick, Gibbet Hill Rd, Coventry, CV4 7AL, UK.; Katsuyama Y; Department of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1, Yayoi, Bunkyo-ku, Tokyo, 113-8657, Japan.; Collaborative Research Institute for Innovative Microbiology, The University of Tokyo, 1-1-1, Yayoi, Bunkyo-ku, Tokyo, 113-8657, Japan.; Korenskaia A; Translational Genome Mining for Natural Products, Interfaculty Institute of Microbiology and Infection Medicine Tübingen (IMIT), Interfaculty Institute for Biomedical Informatics (IBMI), University of Tübingen, Sand 14, 72076 Tübingen, Germany.; Krug D; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Campus E8.1, 66123 Saarbrücken, Germany.; Saarland University, Campus E8.1, 66123 Saarbrücken, Germany.; Department of Microbial Drugs, Helmholtz Centre for Infection Research (HZI), Inhoffenstr. 7, 38124 Braunschweig, Germany.; Libis V; Université Paris Cité - Inserm Unit 1284, 75015 Paris, France.; Translational Genome Mining for Natural Products, Generare Bioscience, 75011 Paris, Île-de-France, France.; Lund GA; Sustainable Soils and Crops, Rothamsted Research, West Common, Harpenden, Hertfordshire, AL5 2JQ, UK.; Mantri S; Computational Biology Lab, National Agri-Food and Biomanufacturing Institute (NABI), Sector 81, S.A.S. Nagar, Mohali, Punjab 140306, India.; Regional Centre for Biotechnology, NCR Biotech Science Cluster, 3rd Milestone, Faridabad-Gurugram Expressway, Faridabad - 121001 Haryana (NCR Delhi), India.; Morgan KD; Department of Chemistry and Biochemistry, University of Northern British Columbia, 3333 University Way, Prince George, BC, V2N 4Z9, Canada.; Owen C; Biochemistry and Metabolism, John Innes Centre, Norwich Research Park, Colney Lane, Norwich, NR4 7UH, UK.; Phan CS; Latvian Institute of Organic Synthesis, Aizkraukles street 21, LV-1006 Riga, Latvia.; Philmus B; Department of Pharmaceutical Sciences, Oregon State University, 1601 SW Jefferson Way, Corvallis, OR 97331-3507, USA.; Reitz ZL; Department of Ecology, Evolution and Marine Biology, University of California, 1169 Biological Sciences II, Santa Barbara, CA 93106, USA.; Robinson SL; Department of Environmental Microbiology, Swiss Federal Institute of Aquatic Science and Technology, Ueberlandstrasse 133, 8600 Duebendorf, Switzerland.; Singh KS; Bioinformatics Group, Wageningen University & Research, Droevendaalsesteeg 1, 6708 PB Wageningen, The Netherlands.; Plant-Microbe Interactions, Institute of Environmental Biology, Utrecht University, 3584 CH Utrecht, The Netherlands.; Faculty of Environment, Science and Economy, University of Exeter, TR10 9FE, Penryn, Cornwall, UK.; Teufel R; Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland.; Tong Y; State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Minhang District, Shanghai 200240, China.; Tugizimana F; Department of Biochemistry, University of Johannesburg, C2 Lab Building 224, Kingsway Campus, Cnr University & Kingsway Road, Auckland Park, Johannesburg 2006, South Africa.; International Research and Development (R&D) Division, Omnia Nutriology, Omnia Holdings Ltd, Building H, Monte Circle, 178 Montecasino Blvd, Fourways, Sandton, 2055, South Africa.; Ulanova D; Department of Marine Resource Science, Faculty of Agriculture and Marine Science, Kochi University, 200 Otsu, Monobe, Nankoku-shi, Kochi, 783-8502, Japan.; Marine Core Research Institute, Kochi University, 200 Otsu, Monobe, Nankoku-shi, Kochi, 783-8502, Japan.; Winter JM; Department of Pharmacology and Toxicology, University of Utah, 30 S 2000 E, Salt Lake City, Utah, 84112, USA.; Aguilar C; Industrial Genomics Laboratory, Centro de Biotecnología FEMSA, Escuela de Ingeniería y Ciencias, Tecnológico de Monterrey, Av. Eugenio Garza Sada 2501sur, Nuevo Leon, 64700, México.; Department of Chemistry, Purdue University, 610 Purdue Mall, West Lafayette, IN, 47907, USA.; Akiyama DY; Department of Organic Chemistry, Institute of Chemistry, University of Campinas (UNICAMP), Rua Monteiro Lobato 270, Campinas, São Paulo, 13.083-862, Brazil.; Al-Salihi SAA; Department of Applied Sciences, University of Technology, Al-Sina'a St., 10066, Baghdad, Iraq.; Alanjary M; Bioinformatics Group, Wageningen University & Research, Droevendaalsesteeg 1, 6708 PB Wageningen, The Netherlands.; Alberti F; School of Life Sciences, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK.; Aleti G; Department of Food and Animal Sciences, College of Agriculture, Tennessee State University, Nashville, TN 37209, USA.; Alharthi SA; Department of Biosciences, Swansea University, Singleton Park, Swansea, SA2 8PP, UK.; Rojo MYA; Escuela Nacional de Estudios Superiores Unidad Leon, Universidad Nacional Autonoma de Mexico, Blv. UNAM #2011, Predio El Saucillo y, Comunidad de los Tepetates, El Potrero, 37684 León de los Aldama, Gto., Mexico.; Arishi AA; School of Molecular Sciences, University of Western Australia, 35 Stirling Highway, Perth 6009, Australia.; Department of Botany and Microbiology, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia.; Augustijn HE; Bioinformatics Group, Wageningen University & Research, Droevendaalsesteeg 1, 6708 PB Wageningen, The Netherlands.; Institute of Biology, Leiden University, Sylviusweg 72, 2333BE Leiden, The Netherlands.; Avalon NE; Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0212, USA.; Avelar-Rivas JA; Unidad de Genómica Avanzada, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Km 9.6 Libramiento Norte Carretera Irapuato-León, 36824, Irapuato, Mexico.; Axt KK; Department of Pharmaceutical Sciences, Oregon State University, 1601 SW Jefferson Way, Corvallis, OR 97331-3507, USA.; Barbieri HB; Department of Organic Chemistry, Institute of Chemistry, University of Campinas (UNICAMP), Rua Monteiro Lobato 270, Campinas, São Paulo, 13.083-862, Brazil.; Barbosa JCJ; Department of Organic Chemistry, Institute of Chemistry, University of Campinas (UNICAMP), Rua Monteiro Lobato 270, Campinas, São Paulo, 13.083-862, Brazil.; Barboza Segato LG; Department of Chemistry, University of Manitoba, 66 Chancellors Circle, Winnipeg, MB R3T 2N2, Canada.; Barrett SE; Department of Chemistry, University of Illinois Urbana-Champaign, 600 S. Matthews Ave, Urbana, IL 61801, USA.; Carl R. Woese Institute for Genomic Biology, University of Illinois Urbana-Champaign, 1206 W. Gregory Drive, Urbana, IL 61801, USA.; Baunach M; Institute of Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115 Bonn, Germany.; Beemelmanns C; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Campus E8.1, 66123 Saarbrücken, Germany.; Saarland University, Campus E8.1, 66123 Saarbrücken, Germany.; Beqaj D; Interfaculty Institute of Microbiology and Infection Medicine Tübingen, Microbial Bioactive Compounds, University of Tübingen, Auf der Morgenstelle 28, 72076, Tübingen, Germany.; Berger T; Institute of Pharmaceutical Biology and Biotechnology, University of Marburg, Robert-Koch-Str. 4, 35037 Marburg, Germany.; Bernaldo-Agüero J; Departamento de Microbiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Av. Universidad 2001, Chamilpa, 62210 Cuernavaca, Morelos, México.; Facultad de Ciencias Biológicas, Universidad Nacional Mayor de San Marcos, Av. Germán Amézaga S/N, Ciudad Universitaria, UNMSM, Lima 15081, Perú.; Bettenbühl SM; Institute for Molecular Bio Science, Goethe University Frankfurt, Max-von-Laue Strasse 9, 60438 Frankfurt am Main, Germany.; LOEWE Center for Translational Biodiversity Genomics (TBG), Senckenberganlage 25, 60325 Frankfurt am Main, Germany.; Bielinski VA; Departamento de Bioquímica, Instituto de Química, Universidade Federal do Rio de Janeiro, Avenida Athos da Silveira Ramos, no 149, Rio de Janeiro, 21941-909, Brazil.; Biermann F; Bioinformatics Group, Wageningen University & Research, Droevendaalsesteeg 1, 6708 PB Wageningen, The Netherlands.; Institute for Molecular Bio Science, Goethe University Frankfurt, Max-von-Laue Strasse 9, 60438 Frankfurt am Main, Germany.; LOEWE Center for Translational Biodiversity Genomics (TBG), Senckenberganlage 25, 60325 Frankfurt am Main, Germany.; Borges RM; Instituto de Pesquisas de Produtos Naturais Walter Mors, Universidade Federal do Rio de Janeiro, CCS - Av. Carlos Chagas Filho, 373 - Bloco H - Cidade Universitária, Rio de Janeiro - RJ, 21941-599, Brazil.; Borriss R; Department of Biology, Humboldt University Berlin, Invaliden-Str. 42, 10115 Berlin, Germany.; Institute of Marine Biotechnology (IMaB), University of Greifswald,Walter-Rathenau-Str. 49A, 17489 Greifswald, Germany.; Breitenbach M; Institute for Molecular Bio Science, Goethe University Frankfurt, Max-von-Laue Strasse 9, 60438 Frankfurt am Main, Germany.; LOEWE Center for Translational Biodiversity Genomics (TBG), Senckenberganlage 25, 60325 Frankfurt am Main, Germany.; Bretscher KM; Institute of Biology, Leiden University, Sylviusweg 72, 2333BE Leiden, The Netherlands.; Department of Crop Protection, Instituto de Hortofruticultura Subtropical y Mediterránea 'La Mayora' (IHSM-UMA-CSIC), Campus Universitario de Teatinos, 29010, Málaga, Spain.; Department of Microbial Ecology, Netherlands Institute of Ecology (NIOO-KNAW), Droevendaalsesteeg 10 6708 PB Wageningen, The Netherlands.; Brigham MW; School of Cellular and Molecular Biology, Faculty of Biological Sciences, University of Leeds, 6 Clarendon Way, Woodhouse, Leeds, LS2 3AA, UK.; Buedenbender L; CICA - Centro Interdisciplinar de Química e Bioloxía, Universidade da Coruña, As Carballeiras, s/n, Campus de Elviña, 15071 A Coruña, Spain.; Bulcock BW; School of Molecular Sciences, University of Western Australia, 35 Stirling Highway, Perth 6009, Australia.; Cano-Prieto C; The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Building 220, Søltofts Plads, 2800 Kongens Lyngby, Denmark.; Capela J; Centre of Biological Engineering, University of Minho, 4710-057, Braga, Portugal.; Carrion VJ; Institute of Biology, Leiden University, Sylviusweg 72, 2333BE Leiden, The Netherlands.; Department of Crop Protection, Instituto de Hortofruticultura Subtropical y Mediterránea 'La Mayora' (IHSM-UMA-CSIC), Campus Universitario de Teatinos, 29010, Málaga, Spain.; Department of Microbiology, Faculty of Science, Campus Universitario de Teatinos s/n, University of Málaga, 29010 Málaga, Spain.; Carter RS; Department of Chemistry, University of Illinois Urbana-Champaign, 600 S. Matthews Ave, Urbana, IL 61801, USA.; Carl R. Woese Institute for Genomic Biology, University of Illinois Urbana-Champaign, 1206 W. Gregory Drive, Urbana, IL 61801, USA.; Castelo-Branco R; Interdisciplinary Centre of Marine and Environmental Research (CIIMAR/CIMAR), University of Porto, 4450-208 Matosinhos, Portugal.; Castro-Falcón G; Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0212, USA.; Chagas FO; Instituto de Pesquisas de Produtos Naturais Walter Mors, Universidade Federal do Rio de Janeiro, CCS - Av. Carlos Chagas Filho, 373 - Bloco H - Cidade Universitária, Rio de Janeiro - RJ, 21941-599, Brazil.; Charria-Girón E; Department of Microbial Drugs, Helmholtz Centre for Infection Research (HZI), Inhoffenstr. 7, 38124 Braunschweig, Germany.; Institute of Microbiology, Technische Universität Braunschweig, Spielmannstraße 7, 38106 Braunschweig, Germany.; Chaudhri AA; Institute for Molecular Bio Science, Goethe University Frankfurt, Max-von-Laue Strasse 9, 60438 Frankfurt am Main, Germany.; LOEWE Center for Translational Biodiversity Genomics (TBG), Senckenberganlage 25, 60325 Frankfurt am Main, Germany.; Chaudhry V; Microbial Interactions in Plant Ecosystems, IMIT/ZMBP, Eberhard Karls University of Tübingen, 72076 Tübingen, Germany.; Choi H; College of Pharmacy, Yeungnam University, 280 Daehak-ro Gyeongsan-Si, Gyeongsangbuk-do 38541, Republic of Korea.; Research Institute of Cell Culture, Yeungnam University, 280 Daehak-ro Gyeongsan-Si, Gyeongsangbuk-do 38541, Republic of Korea.; Choi Y; College of Pharmacy and Drug Information Research Institute, Sookmyung Women's University, 100 Cheongpa-ro 47 gil, Seoul 04310, Republic of Korea.; Choupannejad R; Fungal Natural Products, Westerdijk Fungal Biodiversity Institute, Uppsalalaan 8, 3584CT Utrecht, The Netherlands.; Chromy J; Manchester Institute of Biotechnology, Department of Chemistry, School of Natural Sciences, Faculty of Science and Engineering, University of Manchester, 131 Princess Street, Manchester M1 7DN, UK.; Donahey MSC; Department of Microbiology and Cell Science, University of Florida, 1355 Museum Drive, Gainesville, Florida, 32611, USA.; Collemare J; Fungal Natural Products, Westerdijk Fungal Biodiversity Institute, Uppsalalaan 8, 3584CT Utrecht, The Netherlands.; Connolly JA; Manchester Institute of Biotechnology, Department of Chemistry, School of Natural Sciences, Faculty of Science and Engineering, University of Manchester, 131 Princess Street, Manchester M1 7DN, UK.; Creamer KE; Innovative Genomics Institute, University of California Berkeley, 2151Berkeley Way, Berkeley, CA 94720, USA.; Department of Earth and Planetary Science, University of California, 307 McCone Hall Berkeley, CA 94720-4767, USA.; Crüsemann M; Institute of Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115 Bonn, Germany.; Cruz AA; Escuela Nacional de Estudios Superiores Unidad Leon, Universidad Nacional Autonoma de Mexico, Blv. UNAM #2011, Predio El Saucillo y, Comunidad de los Tepetates, El Potrero, 37684 León de los Aldama, Gto., Mexico.; Cumsille A; Department of Microbiology and Cell Science, University of Florida, 1355 Museum Drive, Gainesville, Florida, 32611, USA.; Dallery JF; Université Paris-Saclay, INRAE, UR BIOGER, 22 place de l'Agronomie, 91120 Palaiseau, France.; Damas-Ramos LC; The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Building 220, Søltofts Plads, 2800 Kongens Lyngby, Denmark.; Damiani T; IOCB Prague, Czech Academy of Science, Flemingovo náměstí 542/2, 160 00 Praha 6, Czech Republic.; de Kruijff M; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Campus E8.1, 66123 Saarbrücken, Germany.; Martín BD; Department of Microbiology, Faculty of Science, Campus Universitario de Teatinos s/n, University of Málaga, 29010 Málaga, Spain.; Sala GD; Department of Ecosustainable Marine Biotechnology, Stazione Zoologica Anton Dohrn, Giardini del Molosiglio, Via A.F. Acton 55, 80133 Naples, Italy.; Dillen J; Department of Bioscience Engineering, Research Group Laboratory of Applied Microbiology and Biotechnology, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp, Belgium.; Doering DT; US Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA.; Dommaraju SR; Department of Chemistry, University of Illinois Urbana-Champaign, 600 S. Matthews Ave, Urbana, IL 61801, USA.; Carl R. Woese Institute for Genomic Biology, University of Illinois Urbana-Champaign, 1206 W. Gregory Drive, Urbana, IL 61801, USA.; Durusu S; Institute for Molecular Bio Science, Goethe University Frankfurt, Max-von-Laue Strasse 9, 60438 Frankfurt am Main, Germany.; LOEWE Center for Translational Biodiversity Genomics (TBG), Senckenberganlage 25, 60325 Frankfurt am Main, Germany.; Egbert S; Department of Chemistry, University of Manitoba, 66 Chancellors Circle, Winnipeg, MB R3T 2N2, Canada.; Ellerhorst M; Biochemistry of Microorganisms, Faculty of Life Sciences: Food, Nutrition, and Health, University of Bayreuth, Fritz-Hornschuch-Straße 13, 95326 Kulmbach, Germany.; Faussurier B; Université Paris Cité - Inserm Unit 1284, 75015 Paris, France.; Translational Genome Mining for Natural Products, Generare Bioscience, 75011 Paris, Île-de-France, France.; Fetter A; Newcastle University, Biosciences Institute, Catherine Cookson Building, Newcastle upon Tyne, NE2 4HH, UK.; Feuermann M; SIB Swiss Institute of Bioinformatics, Centre Medical Universitaire, 1 rue Michel Servet, 1211 Geneva 4, Switzerland.; Fewer DP; Department of Microbiology, University of Helsinki, Viikinkaari 9, 00017, Helsinki, Finland.; Foldi J; Manchester Institute of Biotechnology, Department of Chemistry, School of Natural Sciences, Faculty of Science and Engineering, University of Manchester, 131 Princess Street, Manchester M1 7DN, UK.; Frediansyah A; Research Center for Food Technology and Processing, Research Organization of Agriculture and Food, National Research and Innovation Agency (BRIN), Jl. Jogja - Wonosari Km 31.5, DI. Yogyakarta 55861, Indonesia.; Microbial Metabolites for Food Research Group, National Research and Innovation Agency (BRIN), Jl. Jogja - Wonosari Km 31.5, Gunungkidul, DI. Yogyakarta 55861, Indonesia.; Garza EA; Microbial and Environmental Genomics Group, J. Craig Venter Institute, 4120 Capricorn Lane, La Jolla, CA 92037, USA.; Gavriilidou A; Translational Genome Mining for Natural Products, Interfaculty Institute of Microbiology and Infection Medicine Tübingen (IMIT), Interfaculty Institute for Biomedical Informatics (IBMI), University of Tübingen, Sand 14, 72076 Tübingen, Germany.; Gentile A; NAICONS Srl, viale Ortles 22/4, 20139 Milan, Italy.; Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Biosciences complex - Pavilion 02, Sciences and Technology Campus 11/A, 43124 Parma, Italy.; Gerke J; Institute for Organic Chemistry, Leibniz Universität Hannover, Schneiderberg 38, 30167 Hannover, Germany.; Gerstmans H; VIB-KU Leuven Center for Microbiology, Flanders Institute for Biotechnology, Kasteelpark Arenberg 31, 3001 Leuven, Belgium.; Department of Biology, Laboratory for Biomolecular Discovery & Engineering, KU Leuven, Kasteelpark Arenberg 31, 3001 Leuven, Belgium.; Department of Biosystems, Biosensors Group, KU Leuven, Willem de Croylaan 42, box 2428, 3001 Leuven, Belgium.; Gomez-Escribano JP; Leibniz Institute DSMZ - German Collection of Microorganisms and Cell Cultures GmbH, Inhoffenstraße 7B, 38124Braunschweig, Germany.; González-Salazar LA; Industrial Genomics Laboratory, Centro de Biotecnología FEMSA, Escuela de Ingeniería y Ciencias, Tecnológico de Monterrey, Av. Eugenio Garza Sada 2501sur, Nuevo Leon, 64700, México.; Grayson NE; Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0212, USA.; Greco C; Department of Biosciences, Swansea University, Singleton Park, Swansea, SA2 8PP, UK.; Gomez JEG; Industrial Genomics Laboratory, Centro de Biotecnología FEMSA, Escuela de Ingeniería y Ciencias, Tecnológico de Monterrey, Av. Eugenio Garza Sada 2501sur, Nuevo Leon, 64700, México.; Guerra S; Department of Microbiology and Cell Science, University of Florida, 1355 Museum Drive, Gainesville, Florida, 32611, USA.; University of Florida Genetics Institute, University of Florida, 2033 Mowry Rd, Gainesville, FL 32611, USA.; Flores SG; Centro de Ciencias Matemáticas National Autonomous University of Mexico (UNAM) Antigua Carretera a Pátzcuaro # 8701, Sin Nombre, Residencial San José de la Huerta, 58089 Morelia, Mich.; Gurevich A; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Campus E8.1, 66123 Saarbrücken, Germany.; Saarland University, Campus E8.1, 66123 Saarbrücken, Germany.; Gutiérrez-García K; Biosphere Sciences and Engineering Division, Carnegie Institution for Science, 3520 San Martin Dr, Baltimore, MD, 21218, USA.; Hart L; Program in Chemical Biology, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI, USA.; Life Sciences Institute, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, Michigan, USA.; Haslinger K; Department of Chemical and Pharmaceutical Biology, University of Groningen, Antonius Deusinglaan 1, 9713AV Groningen, The Netherlands.; He B; Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, China.; Hebra T; IOCB Prague, Czech Academy of Science, Flemingovo náměstí 542/2, 160 00 Praha 6, Czech Republic.; Hemmann JL; Department of Biomolecular Chemistry, Leibniz Institute for Natural Product Research and Infection Biology (HKI), Adolf-Reichwein-Straße 23, 07745 Jena, Germany.; Hindra H; Institute of Infectious Disease Research, McMaster University, 1280 Main Street West, Hamilton, Ontario, L8S4L8, Canada.; Department of Biology, McMaster University, 1280 Main Street West, Hamilton, Ontario, L8S4K1, Canada.; Höing L; Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland.; Holland DC; School of Molecular Sciences, University of Western Australia, 35 Stirling Highway, Perth 6009, Australia.; Holme JE; Department of Biotechnology and Nanomedicine, SINTEF Industry, P.O.Box 4760 Torgard, N-7465 Trondheim, Norway.; Horch T; The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Building 220, Søltofts Plads, 2800 Kongens Lyngby, Denmark.; Hrab P; Bioinformatics Group, Wageningen University & Research, Droevendaalsesteeg 1, 6708 PB Wageningen, The Netherlands.; Microbiology Group, Wageningen University & Research, Droevendaalsesteeg 1, 6708 PB Wageningen, The Netherlands.; Hu J; Corteva Agriscience, 9330 Zionsville Road, Indianapolis, Indiana 46268, USA.; Huynh TH; Natural Products Research Institute, College of Pharmacy, Seoul National University, 101 Daehak-ro, Jongro-gu, Seoul 110-744, Korea.; Hwang JY; Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, USA.; Iacovelli R; Production Host Engineering Team, VTT Technical Research Centre of Finland Ltd, Maarintie 3, 02150 Espoo, Finland.; Iftime D; Interfaculty Institute of Microbiology and Infection Medicine Tübingen, Microbial Bioactive Compounds, University of Tübingen, Auf der Morgenstelle 28, 72076, Tübingen, Germany.; Iorio M; NAICONS Srl, viale Ortles 22/4, 20139 Milan, Italy.; Jayachandran S; The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Building 220, Søltofts Plads, 2800 Kongens Lyngby, Denmark.; Jeong E; College of Pharmacy and Drug Information Research Institute, Sookmyung Women's University, 100 Cheongpa-ro 47 gil, Seoul 04310, Republic of Korea.; Jing J; Bioinformatics Group, Wageningen University & Research, Droevendaalsesteeg 1, 6708 PB Wageningen, The Netherlands.; Jung JJ; Natural Products Research Institute, College of Pharmacy, Seoul National University, 101 Daehak-ro, Jongro-gu, Seoul 110-744, Korea.; Kakumu Y; Institute for Molecular Bio Science, Goethe University Frankfurt, Max-von-Laue Strasse 9, 60438 Frankfurt am Main, Germany.; LOEWE Center for Translational Biodiversity Genomics (TBG), Senckenberganlage 25, 60325 Frankfurt am Main, Germany.; Kalkreuter E; Department of Chemistry and Biochemistry, Laboratories of Molecular Recognition, Florida State University, 95 Chieftan Way, Tallahassee, FL 32306, USA.; Kang KB; College of Pharmacy and Drug Information Research Institute, Sookmyung Women's University, 100 Cheongpa-ro 47 gil, Seoul 04310, Republic of Korea.; Kang S; Natural Products Research Institute, College of Pharmacy, Seoul National University, 101 Daehak-ro, Jongro-gu, Seoul 110-744, Korea.; Kim W; Department of Applied Biology, College of Agriculture and Life Sciences, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju, 61186, South Korea.; Kim GJ; Research Institute of Cell Culture, Yeungnam University, 280 Daehak-ro Gyeongsan-Si, Gyeongsangbuk-do 38541, Republic of Korea.; Department of Pharmacology, College of Medicine, Dongguk University, Dongdae-ro 123, Gyeongju-si, Gyeongsangbuk-do 38066, Republic of Korea.; Kim H; College of Pharmacy and Integrated Research Institute for Drug Development, Dongguk University-Seoul, Dongguk-ro 32, Goyang 10326, Republic of Korea.; Kim HU; Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea.; Klapper M; Department of Paleobiotechnology, Leibniz Institute for Natural Product Research and Infection Biology Hans Knöll Institute, Beutenbergstr. 11a, 07745 Jena, Germany.; Koetsier RA; Bioinformatics Group, Wageningen University & Research, Droevendaalsesteeg 1, 6708 PB Wageningen, The Netherlands.; Kollten C; Chair of Technical Biochemistry, Technical University of Dresden, Bergstraße 66, 01069 Dresden, Germany.; Kovács ÁT; Institute of Biology, Leiden University, Sylviusweg 72, 2333BE Leiden, The Netherlands.; DTU Bioengineering, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark.; Kriukova Y; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Campus E8.1, 66123 Saarbrücken, Germany.; Chair of Technical Biochemistry, Technical University of Dresden, Bergstraße 66, 01069 Dresden, Germany.; Kubach N; Translational Genome Mining for Natural Products, Interfaculty Institute of Microbiology and Infection Medicine Tübingen (IMIT), Interfaculty Institute for Biomedical Informatics (IBMI), University of Tübingen, Sand 14, 72076 Tübingen, Germany.; Kunjapur AM; Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, DE, USA.; Kushnareva AK; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Campus E8.1, 66123 Saarbrücken, Germany.; Saarland University, Campus E8.1, 66123 Saarbrücken, Germany.; Kust A; Innovative Genomics Institute, University of California Berkeley, 2151Berkeley Way, Berkeley, CA 94720, USA.; Department of Earth and Planetary Science, University of California, 307 McCone Hall Berkeley, CA 94720-4767, USA.; Lamber J; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Campus E8.1, 66123 Saarbrücken, Germany.; Saarland University, Campus E8.1, 66123 Saarbrücken, Germany.; German Centre for Infection Research (DZIF), Inhoffenstr. 7, 38124 Hannover-Braunschweig, Germany.; Larralde M; Center of Infectious Diseases, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, Netherlands.; Larsen NJ; The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Building 220, Søltofts Plads, 2800 Kongens Lyngby, Denmark.; Launay AP; Bioinformatics department, Endogenomiks, El Marqués, Querétaro, Mexico.; Le NT; Université Paris Cité - Inserm Unit 1284, 75015 Paris, France.; Lebeer S; Department of Bioscience Engineering, Research Group Laboratory of Applied Microbiology and Biotechnology, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp, Belgium.; U-MaMi Centre of Excellence, Middelheimlaan 1, 2020 Antwerp, Belgium.; Lee BT; Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea.; Lee K; College of Pharmacy and Drug Information Research Institute, Sookmyung Women's University, 100 Cheongpa-ro 47 gil, Seoul 04310, Republic of Korea.; Lev KL; Program in Chemical Biology, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI, USA.; Life Sciences Institute, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, Michigan, USA.; Li SM; Institute of Pharmaceutical Biology and Biotechnology, University of Marburg, Robert-Koch-Str. 4, 35037 Marburg, Germany.; Li YX; Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, China.; Licona-Cassani C; Industrial Genomics Laboratory, Centro de Biotecnología FEMSA, Escuela de Ingeniería y Ciencias, Tecnológico de Monterrey, Av. Eugenio Garza Sada 2501sur, Nuevo Leon, 64700, México.; Integrative Biology Research Unit, The Institute for Obesity Research, Tecnológico de Monterrey, Av. Eugenio Garza Sada 2501 sur, Nuevo Leon, 64700. México.; Lien A; Bioinformatics Group, Wageningen University & Research, Droevendaalsesteeg 1, 6708 PB Wageningen, The Netherlands.; Liu J; Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, China.; Lopez JAV; School of Innovation and Sustainability, De La Salle University, Laguna Boulevard, LTI Spine Road, Brgys. Biñan and Malamig, 4024 Biñan City, Laguna, Philippines.; Department of Chemistry, De La Salle University, 2401 Taft Avenue, 0922 Manila, Philippines.; Machushynets NV; Institute of Biology, Leiden University, Sylviusweg 72, 2333BE Leiden, The Netherlands.; Macias MI; University of Strathclyde, Strathclyde Institute of Pharmacy and Biomedical Sciences, Glasgow, G4 0RE UK.; Mahmud T; Department of Pharmaceutical Sciences, Oregon State University, 1601 SW Jefferson Way, Corvallis, OR 97331-3507, USA.; Maleckis M; Department of Biotechnology and Biomedicine, Technical University of Denmark, Søltofts Plads, Building 221, 2800 Kgs. Lyngby, Denmark.; Martinez-Martinez AM; Industrial Genomics Laboratory, Centro de Biotecnología FEMSA, Escuela de Ingeniería y Ciencias, Tecnológico de Monterrey, Av. Eugenio Garza Sada 2501sur, Nuevo Leon, 64700, México.; Mast Y; Leibniz Institute DSMZ - German Collection of Microorganisms and Cell Cultures GmbH, Inhoffenstraße 7B, 38124Braunschweig, Germany.; Technical University of Braunschweig, Institute of Microbiology, Rebenring 56, 38106 Braunschweig, Germany.; Maximo MF; Department of Organic Chemistry, Institute of Chemistry, University of Campinas (UNICAMP), Rua Monteiro Lobato 270, Campinas, São Paulo, 13.083-862, Brazil.; McBride CM; Program in Chemical Biology, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI, USA.; Life Sciences Institute, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, Michigan, USA.; McLellan RM; Ferrier Research Institute, Victoria University of Wellington, Kelburn Parade, Wellington 6012, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, Victoria University of Wellington, Kelburn Parade, Wellington 6012, New Zealand.; Bhatt KM; Fungal Natural Products, Westerdijk Fungal Biodiversity Institute, Uppsalalaan 8, 3584CT Utrecht, The Netherlands.; Melkonian C; Bioinformatics Group, Wageningen University & Research, Droevendaalsesteeg 1, 6708 PB Wageningen, The Netherlands.; Theoretical Biology and Bioinformatics, Department of Biology, Faculty of Science, Utrecht University, 3584 CH Utrecht, The Netherlands.; Merrild A; Department of Biological and Chemical Engineering, Aarhus University, Gustav Wieds Vej 10, 8000 Aarhus C, Denmark.; Metsä-Ketelä M; Department of Life Technologies, University of Turku, Tykistökatu 6, FIN-20520 Turku, Finland.; Mitchell DA; Department of Chemistry, University of Illinois Urbana-Champaign, 600 S. Matthews Ave, Urbana, IL 61801, USA.; Müller AV; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Campus E8.1, 66123 Saarbrücken, Germany.; Saarland University, Campus E8.1, 66123 Saarbrücken, Germany.; German Centre for Infection Research (DZIF), Inhoffenstr. 7, 38124 Hannover-Braunschweig, Germany.; Nguyen GS; Department of Biotechnology and Nanomedicine, SINTEF Industry, P.O.Box 4760 Torgard, N-7465 Trondheim, Norway.; Nguyen HT; School of Molecular Sciences, University of Western Australia, 35 Stirling Highway, Perth 6009, Australia.; Niedermeyer THJ; Institute of Pharmacy, Freie Universität Berlin, Königin-Luise-Str. 2+4, 14195 Berlin, Germany.; O'Hare JH; Instituto de Pesquisas de Produtos Naturais Walter Mors, Universidade Federal do Rio de Janeiro, CCS - Av. Carlos Chagas Filho, 373 - Bloco H - Cidade Universitária, Rio de Janeiro - RJ, 21941-599, Brazil.; Ossowicki A; Department of Crop Protection, Instituto de Hortofruticultura Subtropical y Mediterránea 'La Mayora' (IHSM-UMA-CSIC), Campus Universitario de Teatinos, 29010, Málaga, Spain.; Department of Microbiology, Faculty of Science, Campus Universitario de Teatinos s/n, University of Málaga, 29010 Málaga, Spain.; Ostash BO; Department of Genetics and Biotechnology, Ivan Franko National University of Lviv, Hrushevskoho st 4, Lviv 79005, Ukraine.; German-Ukrainian Core of Excellence in Natural Products Research, Zelena str. 20, Lviv 79005, Ukraine.; Otani H; US Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA.; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA.; Padva L; Institute of Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115 Bonn, Germany.; Paliyal S; Computational Biology Lab, National Agri-Food and Biomanufacturing Institute (NABI), Sector 81, S.A.S. Nagar, Mohali, Punjab 140306, India.; Pan X; Institute of Biology, Leiden University, Sylviusweg 72, 2333BE Leiden, The Netherlands.; Department of Crop Protection, Instituto de Hortofruticultura Subtropical y Mediterránea 'La Mayora' (IHSM-UMA-CSIC), Campus Universitario de Teatinos, 29010, Málaga, Spain.; Department of Microbial Ecology, Netherlands Institute of Ecology (NIOO-KNAW), Droevendaalsesteeg 10 6708 PB Wageningen, The Netherlands.; Panghal M; Computational Biology Lab, National Agri-Food and Biomanufacturing Institute (NABI), Sector 81, S.A.S. Nagar, Mohali, Punjab 140306, India.; Regional Centre for Biotechnology, NCR Biotech Science Cluster, 3rd Milestone, Faridabad-Gurugram Expressway, Faridabad - 121001 Haryana (NCR Delhi), India.; Parade DS; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Campus E8.1, 66123 Saarbrücken, Germany.; Park J; Natural Products Research Institute, College of Pharmacy, Seoul National University, 101 Daehak-ro, Jongro-gu, Seoul 110-744, Korea.; Parra J; Centro de Investigaciones en Productos Naturales (CIPRONA), Universidad de Costa Rica, San José, 11501-2060, Costa Rica.; Centro Nacional de Innovaciones Biotecnológicas (CENIBiot), CeNAT-CONARE, 1174-1200, San José, Costa Rica.; Instituto de Investigaciones Farmacéuticas (INIFAR), Facultad de Farmacia, Universidad de Costa Rica, San José, 11501-2060, Costa Rica.; Rubio MP; Department of Crop Protection, Instituto de Hortofruticultura Subtropical y Mediterránea 'La Mayora' (IHSM-UMA-CSIC), Campus Universitario de Teatinos, 29010, Málaga, Spain.; Department of Microbiology, Faculty of Science, Campus Universitario de Teatinos s/n, University of Málaga, 29010 Málaga, Spain.; Pham HT; College of Pharmacy and Drug Information Research Institute, Sookmyung Women's University, 100 Cheongpa-ro 47 gil, Seoul 04310, Republic of Korea.; Pidot SJ; Department of Microbiology and Immunology at the Doherty Institute, University of Melbourne, Grattan Street, Parkville Victoria, Victoria 3000, Australia.; Piel J; Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zurich, Vladimir-Prelog Weg 4, 8093 Zurich, Switzerland.; Pourmohsenin B; Translational Genome Mining for Natural Products, Interfaculty Institute of Microbiology and Infection Medicine Tübingen (IMIT), Interfaculty Institute for Biomedical Informatics (IBMI), University of Tübingen, Sand 14, 72076 Tübingen, Germany.; Rakhmanov M; Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland.; Ramesh S; Department of Plant Pathology, University of California Davis, One Shields Avenue, Davis, CA 95616-8751, USA.; Rasmussen MH; Department of Chemistry, Aarhus University, Langelandsgade 140, DK-8000, Aarhus C, Denmark.; Rego A; Interdisciplinary Centre of Marine and Environmental Research (CIIMAR/CIMAR), University of Porto, 4450-208 Matosinhos, Portugal.; Reher R; Institute of Pharmaceutical Biology and Biotechnology, University of Marburg, Robert-Koch-Str. 4, 35037 Marburg, Germany.; Rice AJ; Department of Chemistry, University of Illinois Urbana-Champaign, 600 S. Matthews Ave, Urbana, IL 61801, USA.; Rigolet A; Institute of Biology, Leiden University, Sylviusweg 72, 2333BE Leiden, The Netherlands.; Romero-Otero A; The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Building 220, Søltofts Plads, 2800 Kongens Lyngby, Denmark.; Department of Biotechnology and Biomedicine, Technical University of Denmark, Søltofts Plads, Building 221, 2800 Kgs. Lyngby, Denmark.; Rosas-Becerra LR; Institute of Biology, Leiden University, Sylviusweg 72, 2333BE Leiden, The Netherlands.; Unidad de Genómica Avanzada, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Km 9.6 Libramiento Norte Carretera Irapuato-León, 36824, Irapuato, Mexico.; Rosiles PY; Bioinformatics department, Endogenomiks, El Marqués, Querétaro, Mexico.; Rutz A; Institute for Molecular Systems Biology, ETH Zürich, Otto-Stern-Weg 3, 8093 Zürich, Switzerland.; Ryu B; Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0212, USA.; Sahadeo LA; Department of Chemistry, University of Manitoba, 66 Chancellors Circle, Winnipeg, MB R3T 2N2, Canada.; Saldanha M; Department of Microbiology and Cell Science, University of Florida, 1355 Museum Drive, Gainesville, Florida, 32611, USA.; Salvi L; Interfaculty Institute of Microbiology and Infection Medicine Tübingen, Microbial Bioactive Compounds, University of Tübingen, Auf der Morgenstelle 28, 72076, Tübingen, Germany.; Sánchez-Carvajal E; Laboratorio de Microbiología Molecular y Biotecnología Ambiental, Centro de Biotecnología DAL, Universidad Técnica Federico Santa María, Avenida España 1680, 2390123, Valparaíso, Chile.; Santos-Medellin C; Corteva Agriscience, 9330 Zionsville Road, Indianapolis, Indiana 46268, USA.; Sbaraini N; School of Molecular Sciences, University of Western Australia, 35 Stirling Highway, Perth 6009, Australia.; Schoellhorn SM; Department of Chemistry and BioDiscovery Institute, University of North Texas, 1155 Union Circle, Denton, Texas 76203, USA.; Schumm C; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Campus E8.1, 66123 Saarbrücken, Germany.; German Centre for Infection Research (DZIF), Inhoffenstr. 7, 38124 Hannover-Braunschweig, Germany.; Helmholtz Centre for Infection Research (HZI), Inhoffenstr. 7, 38124 Braunschweig, Germany.; Sehnal L; Interfaculty Institute of Microbiology and Infection Medicine Tübingen, Microbial Bioactive Compounds, University of Tübingen, Auf der Morgenstelle 28, 72076, Tübingen, Germany.; Masaryk University, Faculty of Science, RECETOX, Kamenice 753/5, 625 00 Brno, Czech Republic.; Selem N; Centro de Ciencias Matemáticas National Autonomous University of Mexico (UNAM) Antigua Carretera a Pátzcuaro # 8701, Sin Nombre, Residencial San José de la Huerta, 58089 Morelia, Mich.; Shah AD; School of Biological Sciences, University of Bristol, Life Sciences Building, 24 Tyndall Avenue, Bristol, BS8 1TQ, UK.; School of Chemistry, University of Bristol, Cantock's Close, Bristol, BS8 1TS, UK.; Shishido TK; Fungal Natural Products, Westerdijk Fungal Biodiversity Institute, Uppsalalaan 8, 3584CT Utrecht, The Netherlands.; Institute of Biotechnology, Helsinki Institute of Life Science, University of Helsinki, Viikinkaari 5, 00790, Helsinki, Finland.; Sieber S; Department of Chemistry, University of Zurich,Winterthurerstrasse 190, 8057 Zurich, Switzerland.; Silviani V; College of Pharmacy, Yeungnam University, 280 Daehak-ro Gyeongsan-Si, Gyeongsangbuk-do 38541, Republic of Korea.; Research Institute of Cell Culture, Yeungnam University, 280 Daehak-ro Gyeongsan-Si, Gyeongsangbuk-do 38541, Republic of Korea.; Singh G; Department of Biology, University of Padova, Via U. Bassi, 58/B, 35121 Padova, Italy.; Botanical Garden, University of Padova, Via Orto Botanico 15, 35123 Padova, Italy.; Singh H; Computational Biology Lab, National Agri-Food and Biomanufacturing Institute (NABI), Sector 81, S.A.S. Nagar, Mohali, Punjab 140306, India.; Sokolova N; Department of Chemical and Pharmaceutical Biology, University of Groningen, Antonius Deusinglaan 1, 9713AV Groningen, The Netherlands.; Sonnenschein EC; Department of Biosciences, Swansea University, Singleton Park, Swansea, SA2 8PP, UK.; Sosio M; NAICONS Srl, viale Ortles 22/4, 20139 Milan, Italy.; Sowa ST; Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland.; Steffen K; Department of Biological Sciences and Evolutionary Studies Initiative, Vanderbilt University, 465 21st Ave S, Nashville, TN 37232, USA.; Stegmann E; Interfaculty Institute of Microbiology and Infection Medicine Tübingen, Microbial Bioactive Compounds, University of Tübingen, Auf der Morgenstelle 28, 72076, Tübingen, Germany.; German Centre for Infection Research (DZIF), Partner Site Tübingen, Hoppe-Seyler-Straße 3, 72076 Tübingen, Germany.; Streiff AB; Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zurich, Vladimir-Prelog Weg 4, 8093 Zurich, Switzerland.; Strüder A; Interfaculty Institute of Microbiology and Infection Medicine Tübingen, Microbial Bioactive Compounds, University of Tübingen, Auf der Morgenstelle 28, 72076, Tübingen, Germany.; Surup F; Department of Microbial Drugs, Helmholtz Centre for Infection Research (HZI), Inhoffenstr. 7, 38124 Braunschweig, Germany.; Institute of Microbiology, Technische Universität Braunschweig, Spielmannstraße 7, 38106 Braunschweig, Germany.; Svenningsen T; Department of Biological and Chemical Engineering, Aarhus University, Gustav Wieds Vej 10, 8000 Aarhus C, Denmark.; Sweeney D; Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0212, USA.; Szenei J; The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Building 220, Søltofts Plads, 2800 Kongens Lyngby, Denmark.; Tagirdzhanov A; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Campus E8.1, 66123 Saarbrücken, Germany.; Saarland University, Campus E8.1, 66123 Saarbrücken, Germany.; Tan B; Institute for Molecular Bio Science, Goethe University Frankfurt, Max-von-Laue Strasse 9, 60438 Frankfurt am Main, Germany.; LOEWE Center for Translational Biodiversity Genomics (TBG), Senckenberganlage 25, 60325 Frankfurt am Main, Germany.; Tarnowski MJ; Department of Biosciences, Swansea University, Singleton Park, Swansea, SA2 8PP, UK.; Terlouw BR; Bioinformatics Group, Wageningen University & Research, Droevendaalsesteeg 1, 6708 PB Wageningen, The Netherlands.; Rey T; DE SANGOSSE, Bonnel, 47480, Pont-Du-Casse, France.; Laboratoire de Recherche en Sciences Végétales, Université de Toulouse, CNRS, Université Toulouse III, Toulouse INP, 24 Chemin de Borde Rouge, Auzeville, 31320, Auzeville-Tolosane, France.; Thome NU; Institute of Biology, Leiden University, Sylviusweg 72, 2333BE Leiden, The Netherlands.; Department of Biology, Laboratory for Biomolecular Discovery & Engineering, KU Leuven, Kasteelpark Arenberg 31, 3001 Leuven, Belgium.; Torres Ortega LR; Bioinformatics Group, Wageningen University & Research, Droevendaalsesteeg 1, 6708 PB Wageningen, The Netherlands.; Tørring T; Department of Biological and Chemical Engineering, Aarhus University, Gustav Wieds Vej 10, 8000 Aarhus C, Denmark.; Trindade M; Institute for Microbial Biotechnology and Metagenomics, Department of Biotechnology, University of the Western Cape, Robert Sobukwe Rd, Bellville, 7535, South Africa.; Truman AW; Department of Molecular Microbiology, John Innes Centre, Norwich Research Park, Norwich, NR4 7UH, United Kingdome, Norwich, UK.; Tvilum M; Department of Biological and Chemical Engineering, Aarhus University, Gustav Wieds Vej 10, 8000 Aarhus C, Denmark.; Udwary DW; US Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA.; Ulbricht C; Institute of Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115 Bonn, Germany.; Vader L; The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Building 220, Søltofts Plads, 2800 Kongens Lyngby, Denmark.; van Wezel GP; Institute of Biology, Leiden University, Sylviusweg 72, 2333BE Leiden, The Netherlands.; Department of Microbial Ecology, Netherlands Institute of Ecology (NIOO-KNAW), Droevendaalsesteeg 10 6708 PB Wageningen, The Netherlands.; Walmsley M; Manchester Institute of Biotechnology, Department of Chemistry, School of Natural Sciences, Faculty of Science and Engineering, University of Manchester, 131 Princess Street, Manchester M1 7DN, UK.; Warnasinghe R; Department of Chemistry, University of Manitoba, 66 Chancellors Circle, Winnipeg, MB R3T 2N2, Canada.; Weddeling HG; Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland.; Weir ANM; VIB-KU Leuven Center for Microbiology, Flanders Institute for Biotechnology, Kasteelpark Arenberg 31, 3001 Leuven, Belgium.; The Rosalind Franklin Institute, R113 Rutherford Appleton Laboratory, Harwell Science and Innovation Campus, Didcot, Oxfordshire, OX11 0QX, UK.; Williams K; School of Biological Sciences, University of Bristol, Life Sciences Building, 24 Tyndall Avenue, Bristol, BS8 1TQ, UK.; School of Applied Sciences, University of the West of England, Frenchay Campus, Coldharbour Lane, Bristol, BS16 1QY, UK.; Williams SE; The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Building 220, Søltofts Plads, 2800 Kongens Lyngby, Denmark.; Witte TE; Department of Chemistry and Biomolecular Sciences, University of Ottawa, 10 Marie Curie Private, Ottawa, Ontario, K1N 6N5, Canada.; Rocca SMW; Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0212, USA.; Microbial and Environmental Genomics Group, J. Craig Venter Institute, 4120 Capricorn Lane, La Jolla, CA 92037, USA.; Yamada K; Department of Life Technologies, University of Turku, Tykistökatu 6, FIN-20520 Turku, Finland.; Yang D; Natural Products Discovery Center, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, University of Florida, Jupiter, Florida 33458, USA.; Yang D; Synthetic Biology and Enzyme Engineering Laboratory, Department of Chemical and Biological Engineering, Korea University, Anam-ro 145, Seongbuk-gu, Seoul 02841, Republic of Korea.; Yu J; Institute of Plant and Food Science, Department of Biology, School of Life Sciences, Southern University of Science and Technology, 1088 Xueyuan Avenue, Shenzhen 518055, P.R. China.; Zhou Z; College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Chaowang Raod 18, Hangzhou 310014, China.; Ziemert N; Translational Genome Mining for Natural Products, Interfaculty Institute of Microbiology and Infection Medicine Tübingen (IMIT), Interfaculty Institute for Biomedical Informatics (IBMI), University of Tübingen, Sand 14, 72076 Tübingen, Germany.; Zimmer L; Institute of Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115 Bonn, Germany.; Zimmermann A; Leibniz Institute DSMZ - German Collection of Microorganisms and Cell Cultures GmbH, Inhoffenstraße 7B, 38124Braunschweig, Germany.; Zimmermann C; Institute of Chemical, Environmental and Bioscience Engineering, TU Wien, Gumpendorfer Strasse 1a, 1060 Vienna, Austria.; van der Hooft JJJ; Bioinformatics Group, Wageningen University & Research, Droevendaalsesteeg 1, 6708 PB Wageningen, The Netherlands.; Department of Biochemistry, University of Johannesburg, C2 Lab Building 224, Kingsway Campus, Cnr University & Kingsway Road, Auckland Park, Johannesburg 2006, South Africa.; Linington RG; Department of Chemistry, Simon Fraser University, 8888 University Drive, Burnaby, British Columbia, V5A 1S6, Canada.; Weber T; The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Building 220, Søltofts Plads, 2800 Kongens Lyngby, Denmark.; Medema MH; Bioinformatics Group, Wageningen University & Research, Droevendaalsesteeg 1, 6708 PB Wageningen, The Netherlands. |
| Source: | Nucleic acids research [Nucleic Acids Res] 2025 Jan 06; Vol. 53 (D1), pp. D678-D690. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE |
| Imprint Name(s): | Publication: 1992- : Oxford : Oxford University Press; Original Publication: London, Information Retrieval ltd. |
| MeSH Terms: | Multigene Family* ; Databases, Genetic*; Biosynthetic Pathways/genetics ; Biological Products/metabolism ; Biological Products/chemistry ; Molecular Sequence Annotation ; Data Curation |
| Abstract: | Specialized or secondary metabolites are small molecules of biological origin, often showing potent biological activities with applications in agriculture, engineering and medicine. Usually, the biosynthesis of these natural products is governed by sets of co-regulated and physically clustered genes known as biosynthetic gene clusters (BGCs). To share information about BGCs in a standardized and machine-readable way, the Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard and repository was initiated in 2015. Since its conception, MIBiG has been regularly updated to expand data coverage and remain up to date with innovations in natural product research. Here, we describe MIBiG version 4.0, an extensive update to the data repository and the underlying data standard. In a massive community annotation effort, 267 contributors performed 8304 edits, creating 557 new entries and modifying 590 existing entries, resulting in a new total of 3059 curated entries in MIBiG. Particular attention was paid to ensuring high data quality, with automated data validation using a newly developed custom submission portal prototype, paired with a novel peer-reviewing model. MIBiG 4.0 also takes steps towards a rolling release model and a broader involvement of the scientific community. MIBiG 4.0 is accessible online at https://mibig.secondarymetabolites.org/.; (© The Author(s) 2024. Published by Oxford University Press on behalf of Nucleic Acids Research.) |
| Grant Information: | Conahcyt Mexico International PhD Studentship; 32170080 National Natural Science Foundation of China; 547394769 German Research Foundation; 101066127 European Union; NNF19SA0059360 Novo Nordisk Foundation INTERACT; Swedish Pharmaceutical Society PostDoc; F32AT011475 United States AT NCCIH NIH HHS; Werner Siemens Foundation; 027/E5/PG.02.00.PL/2024 Ministry of Education; ANR-17-EUR-0007 EUR Saclay Plant Sciences-SPS; PROYEXCEL_00012 Spanish "Junta de Andalucía"; 1347411 CONAHCYT; IM230100154 Australian Research Council Industry Fellowship; 1229222N Research Foundation-Flanders (FWO); R01 GM146224 United States GM NIGMS NIH HHS; Swiss Federal Government; OSF.23.1.044 NWO Open Science Project 'BiG-CODEC'; NWO Merian; R01 GM097142 United States GM NIGMS NIH HHS; 024.004.014 MiCRop Consortium; CZIF2022-007203 Chan Zuckerberg Initiative Foundation; BB/T007222/1 United Kingdom BB_ Biotechnology and Biological Sciences Research Council; DP230102668 Australian Research Council Discovery Project; 57/0009 Ministry of Education and Science of Ukraine; Delta Stewardship Council Delta Science Program; T32 GM136629 United States GM NIGMS NIH HHS; Basic Science Research Program; R01-GM146224 United States GM NIGMS NIH HHS; K12 GM068524 United States GM NIGMS NIH HHS; AUFF-E-2022-9-42 AUFF; 10062709 UK Innovation Funding Agency (UKRI); CBET-2032243 U.S. National Science Foundation; University of Illinois; HZI POF IV Cooperativity and Creativity Project Call; Horizon Europe Marie Skłodowska-Curie Actions Postdoctoral Fellowship; NE/T010959/1 Signals in the Soil; ANR-24-CE20-7299-01 Agence Nationale de la Recherche; DNRF137 Danish National Research Foundation; OCENW.GROOT.2019.063 NWO-XL; BB/V005723/2 BBSRC; 101087181 EU; 101000392 Horizon 2020; 101072485 European Union's Horizon; 10.55776/P 34036 Austrian Science Fund; EP/X03142X/1 United Kingdom Research and Innovation; 23/01956-2 São Paulo Research Foundation; Department of Biotechnology; 222676 USDA Evans-Allen Research; Saarland University; 102022750 SINTEF; Hans Fischer Society; 21K06336 KAKENHI; CF22-1239 Carlsberg Foundation; ANR-22-CE44-0011-01 UMISYN Agence Nationale de la Recherche; 495740318 German Research Foundation; 802736 European Union Horizon 2020; Strathclyde University Global Research Scholarship; NNF22OC0079021 Novo Nordisk Foundation Postdoctoral Fellowship; 101055020-COMMUNITY ERC Advanced; 101099528 European Innovation Council; GNT2021638 National Health and Medical Research Council; 757173 Consejo Nacional de Ciencia y Tecnología; NA22NOS4200050 NERRS; 865738 International ERC_ European Research Council; DGE 2241144 NSF GRFP; National Research Fund of Ukraine; RYC2020-029240-I Ministerio de Ciencia, Innovación y Universidades; MR/V022334/1 UKRI Future Leaders Fellowship; 102029187 SEP AGREE; NNF22OC0078997 Novo Nodisk Foundation; F31 ES036421 United States ES NIEHS NIH HHS; KICH1.LWV04.21.013 NWO; DM60066 Italian Ministry of Research; 101117891-MeDiSyn ERC Starting; European Union's Horizon 2020 Research; R01 GM123998 United States GM NIGMS NIH HHS; NRF 2018R1A5A2023127 Korea Government (MSIT); PS00349981 Fulbright; NRF-2020R1A6A1A03044512 Korean Government (MSIT); 735867 Consejo Nacional de Ciencia y Tecnología; 3141-00013A Innovation Fund Denmark; CFB 2.0 Novo Nordisk Foundation; 21/07038-0 São Paulo Research Foundation; 2021YFA0909500 National Key Research and Development Program of China; 101072485 European Union's Horizon Europe; OCENW.XL21.XL21.088 NWO-XL; University Grants Commission; Natural Science and Research Council of Canada; TTU 09.826 German Center for Infection Research; European Regional Development Fund; 101072485 Horizon Europe Marie Skłodowska-Curie; DNRF137 Danish National Research Foundation CeMiSt; BB/X010953/1 Growing Health Institute Strategic Programme; BB/X01097X/1 BBSRC Institute Strategic Program; 802736 European Union's Horizon 2020; Alexander von Humboldt-Stiftung; UK Government Department for Environment, Food & Rural Affairs (DEFRA) Global Centre on Biodiversity for the Climate; Shanghai Pilot Program for Basic Research - Shanghai Jiao Tong University; 102024676-14 POS BIOINFO 2024; MR/W011247/1 UKRI Future Leaders Fellowship; DGE 21-46756 National Science Foundation Graduate Research Fellowship; 101106349 Marie Sklodowska-Curie; T32-GM136629 Chemical-Biology Interface Training; University of Sydney; 101000794 SECRETed EU Project Horizon 2020; 2022R1C1C2004118 National Research Foundation of Korea; Indonesia Endowment Fund for Education Agency (LPDP); 101130799 European Union's Horizon; 852600 Innovation Program ERC St; National Agri-Food Biotechnology Institute; German Academic Scholarship Foundation; 205320_219638 Switzerland SNSF_ Swiss National Science Foundation; EXC-2124/1-09.029_0 Cluster of Excellence: Controlling Microbes to Fight Infection; F32 AT011475 United States AT NCCIH NIH HHS; 398967434-TRR 261 Deutsche Forschungsgemeinschaft; 212747 Switzerland SNSF_ Swiss National Science Foundation; K445/2022 Leibniz Association; NRF-RS-2024-00352229 Ministry of Science and ICT; Natural Sciences and Engineering Research Council of Canada Discovery; VI.Veni.202.130 NWO Talent; 106/IV/KS/11/2023 National Research and Innovation Agency; T32GM136583 United States NH NIH HHS; DE-AC02-05CH11231 U.S. Department of Energy |
| Substance Nomenclature: | 0 (Biological Products) |
| Entry Date(s): | Date Created: 20241210 Date Completed: 20250108 Latest Revision: 20260514 |
| Update Code: | 20260514 |
| PubMed Central ID: | PMC11701617 |
| DOI: | 10.1093/nar/gkae1115 |
| PMID: | 39657789 |
| Database: | MEDLINE |
Journal Article