Pre- and post-diagnosis body weight trajectories in patients with localized renal cell cancer.
| Title: | Pre- and post-diagnosis body weight trajectories in patients with localized renal cell cancer. |
|---|---|
| Authors: | Vrieling A; IQ Health Science Department, Radboud University Medical Center, Nijmegen, The Netherlands. Alina.Vrieling@radboudumc.nl.; Olsson LT; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Kleuters G; IQ Health Science Department, Radboud University Medical Center, Nijmegen, The Netherlands.; Maurits JSF; IQ Health Science Department, Radboud University Medical Center, Nijmegen, The Netherlands.; Aben K; IQ Health Science Department, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Research and Development, Netherlands Comprehensive Cancer Organisation, Utrecht, The Netherlands.; Sedelaar JPM; Department of Urology, Radboud University Medical Center, Nijmegen, The Netherlands.; Furberg H; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Kiemeney LALM; IQ Health Science Department, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Urology, Radboud University Medical Center, Nijmegen, The Netherlands. |
| Source: | Cancer causes & control : CCC [Cancer Causes Control] 2025 May; Vol. 36 (5), pp. 497-507. Date of Electronic Publication: 2025 Jan 06. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Kluwer Academic Publishers Country of Publication: Netherlands NLM ID: 9100846 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-7225 (Electronic) Linking ISSN: 09575243 NLM ISO Abbreviation: Cancer Causes Control Subsets: MEDLINE |
| Imprint Name(s): | Publication: Dordrecht : Kluwer Academic Publishers; Original Publication: Oxford, UK : Rapid Communications of Oxford Ltd., 1990- |
| MeSH Terms: | Carcinoma, Renal Cell*/diagnosis ; Carcinoma, Renal Cell*/pathology ; Carcinoma, Renal Cell*/epidemiology ; Kidney Neoplasms*/diagnosis ; Kidney Neoplasms*/pathology ; Kidney Neoplasms*/epidemiology ; Obesity*/complications ; Obesity*/epidemiology ; Body-Weight Trajectory*; Humans ; Female ; Male ; Middle Aged ; Prospective Studies ; Aged ; Body Mass Index ; Weight Loss ; Adult ; Risk Factors |
| Abstract: | Purpose: Obesity in mid-life is a well-established risk factor for developing renal cell carcinoma (RCC); however, patients with RCC who are obese at the time of diagnosis have more favorable survival outcomes. To get better insight into the obesity paradox and determine the extent to which weight around diagnosis is stable, we examined pre- and post-diagnosis weight changes in patients with localized RCC.; Methods: We included 334 patients with localized RCC from the prospective cohort ReLife who self-reported body weight at multiple time points ranging from 2 years before to 2 years after diagnosis. Multivariable linear mixed-effects regression models were used to compare weight at each timepoint to weight at diagnosis for the overall study population, as well as stratified by BMI at diagnosis, tumor stage, and tumor grade.; Results: Most patients were classified as overweight (38.3%) or obese (29.6%) at diagnosis. Overall, patients experienced on average 1.45 kg (95% confidence interval (CI) 0.84, 2.06) weight loss in the 2 years before diagnosis. Pre-diagnosis weight loss was higher in patients who were non-obese at diagnosis, and who presented with higher tumor stage and grade. On average, pre-diagnosis weight loss was at least partially regained within two years after diagnosis.; Conclusion: Patients who were non-obese and patients with higher stage and grade tumors had higher pre-diagnosis weight loss, which was at least partially regained after treatment. These patterns suggest there are subgroups of patients with localized RCC who experience disease-related weight loss, which could contribute to the obesity paradox.; (© 2025. The Author(s).) |
| Competing Interests: | Declarations. Conflict of interest: The authors declare no competing interests. Ethical approval: The study was approved by the Committee for Human Research region Arnhem-Nijmegen (CMO 2016–3078). Consent to participate: Participants provided written informed consent. |
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| Grant Information: | T32 CA128582 United States CA NCI NIH HHS; P30 CA008748 United States CA NCI NIH HHS; R01 CA233885 United States CA NCI NIH HHS; KUN 2015-7948 KWF Kankerbestrijding; T32CA128582 United States NH NIH HHS |
| Contributed Indexing: | Keywords: Body weight changes; Cancer survivors; Carcinoma; Obesity paradox; Renal cell |
| Entry Date(s): | Date Created: 20250106 Date Completed: 20250409 Latest Revision: 20250721 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC11982074 |
| DOI: | 10.1007/s10552-024-01957-2 |
| PMID: | 39760894 |
| Database: | MEDLINE |
Journal Article