Hypermethylation of PM20D1 Is Associated With Carotid Bifurcation Intima-Media Thickness in Dominican Republic Families.
| Title: | Hypermethylation of PM20D1 Is Associated With Carotid Bifurcation Intima-Media Thickness in Dominican Republic Families. |
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| Authors: | Dueker ND; John P. Hussman Institute for Human Genomics, University of Miami Miami FL USA.; Zhao H; Department of Biostatistics Yale School of Public Health New Haven CT USA.; Gardener H; Department of Neurology, Miller School of Medicine University of Miami Miami FL USA.; Kaur SS; Department of Neurology, Miller School of Medicine University of Miami Miami FL USA.; Dong C; Department of Neurology, Miller School of Medicine University of Miami Miami FL USA.; Cabral D; Department of Neurology, Miller School of Medicine University of Miami Miami FL USA.; Sacco RL; Department of Neurology, Miller School of Medicine University of Miami Miami FL USA.; Department of Neurology Evelyn F. McKnight Brain Institute, University of Miami Miami FL USA.; Department of Human Genetics Dr. John T. Macdonald Foundation, University of Miami Miami FL USA.; Department of Public Health Sciences, Miller School of Medicine University of Miami Miami FL USA.; Blanton SH; John P. Hussman Institute for Human Genomics, University of Miami Miami FL USA.; Department of Human Genetics Dr. John T. Macdonald Foundation, University of Miami Miami FL USA.; Rundek T; Department of Neurology, Miller School of Medicine University of Miami Miami FL USA.; Department of Neurology Evelyn F. McKnight Brain Institute, University of Miami Miami FL USA.; Wang L; John P. Hussman Institute for Human Genomics, University of Miami Miami FL USA.; Department of Human Genetics Dr. John T. Macdonald Foundation, University of Miami Miami FL USA. |
| Source: | Journal of the American Heart Association [J Am Heart Assoc] 2025 Jan 21; Vol. 14 (2), pp. e034033. Date of Electronic Publication: 2025 Jan 10. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101580524 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2047-9980 (Electronic) Linking ISSN: 20479980 NLM ISO Abbreviation: J Am Heart Assoc Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Oxford : Wiley-Blackwell |
| MeSH Terms: | Carotid Intima-Media Thickness* ; Amidohydrolases* ; DNA Methylation*; Dominican Republic/epidemiology ; Humans ; Male ; Female ; Adolescent ; Young Adult ; Adult ; Middle Aged ; Aged ; Aged, 80 and over ; Quantitative Trait Loci ; Promoter Regions, Genetic ; Life Style ; CpG Islands |
| Abstract: | Background: Carotid intima-media thickness (IMT) is a measure of atherosclerosis and a predictor of vascular diseases. Traditional vascular risk factors and genetic variants do not completely explain the variation in carotid IMT. We sought to identify epigenetic factors that may contribute to the remaining carotid IMT variability.; Methods and Results: An epigenome-wide association study was performed in 61 Dominican families with 769 individuals. A cytosine nucleotide that precedes a guanine nucleotide methylation in blood-derived DNA was measured using the Human MethylationEPIC BeadChip. Linear mixed model analyses were performed regressing bifurcation carotid IMT (bIMT) on beta values for cytosine nucleotide that precedes a guanine nucleotide sites, adjusting for covariates, followed by differentially methylated region (DMR) analysis. One-sample Mendelian randomization analysis was conducted to investigate causal associations between DMRs and bIMT. Twenty-five DMRs were associated with bIMT (Sidak P |
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| Grant Information: | KL2 TR002737 United States TR NCATS NIH HHS; R01 NS040807 United States NS NINDS NIH HHS; R01 NS065114 United States NS NINDS NIH HHS; K24 NS062737 United States NS NINDS NIH HHS; R01 NS047655 United States NS NINDS NIH HHS; K12 TR004555 United States TR NCATS NIH HHS |
| Contributed Indexing: | Keywords: atherosclerosis; epigenetics; race and ethnicity |
| Substance Nomenclature: | EC 3.5.- (PM20D1 protein, human); EC 3.5.- (Amidohydrolases) |
| Entry Date(s): | Date Created: 20250110 Date Completed: 20250213 Latest Revision: 20260307 |
| Update Code: | 20260307 |
| PubMed Central ID: | PMC12054445 |
| DOI: | 10.1161/JAHA.123.034033 |
| PMID: | 39791430 |
| Database: | MEDLINE |
Journal Article