A study looking at how missed somatropin injections affect growth in children with growth hormone deficiency: a plain language summary of publication.
| Title: | A study looking at how missed somatropin injections affect growth in children with growth hormone deficiency: a plain language summary of publication. |
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| Authors: | Loftus J; Pfizer Limited, Tadworth, Surrey, UK.; Miller BS; University of Minnesota Masonic Children's Hospital, Minneapolis, MN, USA.; Parzynski CS; Genesis Research, Hoboken, NJ, USA.; Alvir J; Pfizer Inc., New York, NY, USA.; Chen Y; Pfizer Inc., Collegeville, PA, USA.; Jhingran P; Genesis Research, Hoboken, NJ, USA.; Gupta A; Pfizer Inc., New York, NY, USA.; DeKoven M; IQVIA, Falls Church, VA, USA.; Divino V; IQVIA, Falls Church, VA, USA.; Tse J; IQVIA, Falls Church, VA, USA.; He J; IQVIA, Falls Church, VA, USA.; Wajnrajch M; Pfizer Inc., New York, NY, USA.; New York University Langone Medical Center, New York, NY, USA. |
| Source: | Therapeutic advances in endocrinology and metabolism [Ther Adv Endocrinol Metab] 2025 Feb 09; Vol. 16, pp. 20420188241308446. Date of Electronic Publication: 2025 Feb 09 (Print Publication: 2025). |
| Publication Type: | Journal Article; Review |
| Language: | English |
| Journal Info: | Publisher: Sage Publication Country of Publication: United States NLM ID: 101532143 Publication Model: eCollection Cited Medium: Print ISSN: 2042-0188 (Print) Linking ISSN: 20420188 NLM ISO Abbreviation: Ther Adv Endocrinol Metab Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: Los Angeles : Sage Publication |
| Abstract: | • Children with growth hormone deficiency (GHD) are often prescribed a growth hormone called somatropin to help them grow. • As prescribed, somatropin needs to be injected once a day under the skin. Some children may miss many of their somatropin injections, and this is known as having "low adherence" to treatment. Adherence in this study refers to whether the children had enough somatropin to have daily injections as prescribed. • In this study, researchers found that children with GHD who had high adherence to daily somatropin injections grew more than children who had low adherence to daily somatropin injections. • Researchers, doctors, and nurses need to look at how they can help children with GHD follow their prescribed injection schedule and reduce the number of missed injections. The purpose of this plain language summary is to help you to understand the findings from recent research. • Somatropin is approved to treat the condition under study that is discussed in this summary. • This summary reports the results of a single study. The results of this study may differ from those of other studies. Health professionals should make treatment decisions based on all available evidence, not on the results of a single study. Glossary of commonly used terms Adherence - in this study, adherence refers to whether the children had enough medication (somatropin) to have daily injections as prescribed by their doctor. Growth hormone - a protein made in the pituitary gland that helps the body grow properly. Growth hormone deficiency - children with this condition do not have enough growth hormone in their bodies so they grow more slowly than children with normal levels of growth hormone. Somatropin - a type of human growth hormone that can be made in a laboratory and used to treat growth hormone deficiency.; (© The Author(s), 2025.) |
| Contributed Indexing: | Keywords: adherence; growth; height; pediatric growth hormone deficiency; somatropin |
| Entry Date(s): | Date Created: 20250212 Latest Revision: 20250212 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC11808758 |
| DOI: | 10.1177/20420188241308446 |
| PMID: | 39936080 |
| Database: | MEDLINE |
Journal Article; Review