Castleman disease as the great mimicker: the role of complex morpho-pathological evaluation.
| Title: | Castleman disease as the great mimicker: the role of complex morpho-pathological evaluation. |
|---|---|
| Authors: | Tănase I; Department of Laboratory Medicine, Victor Babeş Clinical Hospital of Infectious Diseases and Pneumophthisiology, Craiova; Doctoral School, University of Medicine and Pharmacy of Craiova, Romania; alinamaria.georgescu@gmail.com; Department of Otorhinolaryngology, Medicover Hospital, Bucharest, Romania; carmeen.badea@gmail.com.; Sarafoleanu CC; Cobzeanu BM; Georgescu AM; Busuioc CI; Iovănescu D; Badea FC |
| Source: | Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie [Rom J Morphol Embryol] 2024 Oct-Dec; Vol. 65 (4), pp. 575-581. |
| Publication Type: | Journal Article; Case Reports |
| Language: | English |
| Journal Info: | Publisher: Editura Academiei Române Country of Publication: Romania NLM ID: 9112454 Publication Model: Print Cited Medium: Internet ISSN: 2066-8279 (Electronic) Linking ISSN: 12200522 NLM ISO Abbreviation: Rom J Morphol Embryol Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Bucuresti, România : Editura Academiei Române, [1990- |
| MeSH Terms: | Castleman Disease*/pathology ; Castleman Disease*/diagnosis; Lymph Nodes/pathology ; Humans ; Female ; Adolescent ; Diagnosis, Differential |
| Abstract: | Castleman disease (CD) is a group of lymphoproliferative disorders characterized by abnormal enlargement of lymph nodes (LNs) and a wide range of symptoms. Only a few cases are found in the head and neck. Based on clinical presentation and evolution, the disease can be classified into two main subtypes: unicentric CD (UCD), characterized by the enlargement of a single LN or a single LN chain, and multicentric CD (MCD), characterized by the involvement of multiple LNs and regions, with more important systemic symptoms and a poor prognosis. CD is also known as "the great mimicker" and can be easily misdiagnosed, sharing similar clinical and imaging characteristics with other pathologies, mainly when it is found in the neck. A histopathological (HP) and immunohistochemical (IHC) correlation is essential in these cases to accurately diagnose and establish the proper treatment plan. In light of this, we present a rare case of a 15-year-old young female with a slowly expanding, isolated supraclavicular mass. An excisional biopsy was performed, and the results confirmed the presence of CD, hyaline-vascular type. As of this writing, there was no evidence of recurrence or new enlarged LNs. We also review CD's clinical and HP features and the diagnostic and treatment challenges it poses. |
| Competing Interests: | The authors declared no potential conflict of interests concerning the research, authorship, and/or publication of this article. |
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| Contributed Indexing: | Keywords: Castleman disease; lymphadenopathy; supraclavicular mass; unicentric Castleman disease |
| Entry Date(s): | Date Created: 20250217 Date Completed: 20250217 Latest Revision: 20250508 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC11924898 |
| DOI: | 10.47162/RJME.65.4.03 |
| PMID: | 39957018 |
| Database: | MEDLINE |
Journal Article; Case Reports