Distinguishing clinical and genetic risk factors for suicidal ideation and behavior in a diverse hospital population.
| Title: | Distinguishing clinical and genetic risk factors for suicidal ideation and behavior in a diverse hospital population. |
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| Authors: | Colbert SMC; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. sarah.colbert@icahn.mssm.edu.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. sarah.colbert@icahn.mssm.edu.; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. sarah.colbert@icahn.mssm.edu.; Lepow L; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Fennessy B; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Iwata N; Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan.; Ikeda M; Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan.; Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan.; Saito T; Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan.; Terao C; Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Clinical Research Center, Shizuoka General Hospital, Shizuoka, Japan.; Department of Applied Genetics, The School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.; Preuss M; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Pathak J; Department of Population Health Sciences, Weill Cornell Medicine/NewYork-Presbyterian, New York, NY, USA.; Mann JJ; Department of Psychiatry, Columbia University Irving Medical Center, Columbia University, New York, NY, USA.; Department of Radiology, Columbia University Irving Medical Center, Columbia University, New York, NY, USA.; Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, NY, USA.; Coon H; Department of Psychiatry & Huntsman Mental Health Institute, University of Utah School of Medicine, Salt Lake City, UT, USA.; Mullins N; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. |
| Source: | Translational psychiatry [Transl Psychiatry] 2025 Feb 20; Vol. 15 (1), pp. 63. Date of Electronic Publication: 2025 Feb 20. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101562664 Publication Model: Electronic Cited Medium: Internet ISSN: 2158-3188 (Electronic) Linking ISSN: 21583188 NLM ISO Abbreviation: Transl Psychiatry Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: New York, NY : Nature Pub. Group |
| MeSH Terms: | Suicide, Attempted*/statistics & numerical data ; Suicide, Attempted*/psychology ; Mental Disorders*/genetics ; Mental Disorders*/psychology ; Suicidal Ideation*; Humans ; Risk Factors ; Male ; Female ; Middle Aged ; Adult ; Multifactorial Inheritance ; Genome-Wide Association Study ; Genetic Predisposition to Disease ; Aged ; Case-Control Studies |
| Abstract: | Suicidal ideation (SI) and behavior (SB) are major public health concerns, but risk factors for their development and progression are poorly understood. We used ICD codes and a natural language processing algorithm to identify individuals in a hospital biobank with SI-only, SB, and controls without either. We compared the profiles of SB and SI-only patients to controls, and each other, using phenome-wide association studies (PheWAS) and polygenic risk scores (PRS). PheWAS identified many risk factors for SB and SI-only, plus specific psychiatric disorders which may be involved in progression from SI-only to SB. PRS for suicide attempt were only associated with SB, and even after accounting for psychiatric disorder PRS. SI PRS were only associated with SI-only, although not after accounting for psychiatric disorder PRS. These findings advance understanding of distinct genetic and clinical risk factors for SB and SI-only, which will aid in early detection and intervention efforts.; (© 2025. The Author(s).) |
| Competing Interests: | Competing interests: Dr. Mann receives royalties for commercial use of the C-SSRS from the Research Foundation for Mental Hygiene and from Columbia University for the Columbia Pathways App. The other authors have no conflicts of interest to declare. Ethics approval and consent to participate: All methods were performed in accordance with the relevant guidelines and regulations. Relevant study activities for the current report were approved by the Icahn School of Medicine at Mount Sinai Institutional Review Board (Institutional Review Board 07 0529) and all study participants provided written informed consent. |
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| Grant Information: | 1842169 National Science Foundation (NSF); 29551 Brain and Behavior Research Foundation (Brain & Behavior Research Foundation); R01MH123489 U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH); S10 OD026880 United States OD NIH HHS; R01 MH123489 United States MH NIMH NIH HHS; T32 MH122394 United States MH NIMH NIH HHS; UL1 TR004419 United States TR NCATS NIH HHS; S10 OD030463 United States OD NIH HHS |
| Entry Date(s): | Date Created: 20250220 Date Completed: 20250508 Latest Revision: 20250801 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC11842747 |
| DOI: | 10.1038/s41398-025-03287-6 |
| PMID: | 39979244 |
| Database: | MEDLINE |
Journal Article