Diminished Mycobacterium tuberculosis-specific T-cell Responses During Pregnancy in Women With HIV and Receiving Isoniazid Preventive Therapy.
| Title: | Diminished Mycobacterium tuberculosis-specific T-cell Responses During Pregnancy in Women With HIV and Receiving Isoniazid Preventive Therapy. |
|---|---|
| Authors: | Saha A; Department of Medicine, University of Washington, Seattle, Washington, USA.; Institute of Public Health Genetics, University of Washington, Seattle, Washington, USA.; Department of Global Health, University of Washington, Seattle, Washington, USA.; Escudero JN; Department of Global Health, University of Washington, Seattle, Washington, USA.; Layouni T; VA Puget Sound Health Care System, Seattle, Washington, USA.; Mecha J; Centre for Respiratory Diseases Research, Kenya Medical Research Institute, Nairobi, Kenya.; Maleche-Obimbo E; Department of Global Health, University of Washington, Seattle, Washington, USA.; Department of Paediatrics and Child Health, University of Nairobi, Nairobi, Kenya.; Matemo D; Centre for Respiratory Diseases Research, Kenya Medical Research Institute, Nairobi, Kenya.; Kinuthia J; Department of Global Health, University of Washington, Seattle, Washington, USA.; Medical Research Department, Kenyatta National Hospital, Nairobi, Kenya.; Department of Reproductive Health, Kenyatta National Hospital, Nairobi, Kenya.; John-Stewart G; Department of Medicine, University of Washington, Seattle, Washington, USA.; Department of Global Health, University of Washington, Seattle, Washington, USA.; Department of Epidemiology, University of Washington, Seattle, Washington, USA.; Department of Pediatrics, University of Washington, Seattle, Washington, USA.; Richardson BA; Department of Global Health, University of Washington, Seattle, Washington, USA.; Department of Biostatistics, University of Washington, Seattle, Washington, USA.; LaCourse SM; Department of Medicine, University of Washington, Seattle, Washington, USA.; Department of Global Health, University of Washington, Seattle, Washington, USA.; Department of Epidemiology, University of Washington, Seattle, Washington, USA.; Shah JA; Department of Medicine, University of Washington, Seattle, Washington, USA.; Institute of Public Health Genetics, University of Washington, Seattle, Washington, USA.; VA Puget Sound Health Care System, Seattle, Washington, USA. |
| Source: | Open forum infectious diseases [Open Forum Infect Dis] 2025 Feb 05; Vol. 12 (2), pp. ofaf067. Date of Electronic Publication: 2025 Feb 05 (Print Publication: 2025). |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Published by Oxford University Press on behalf of the Infectious Diseases Society of America Country of Publication: United States NLM ID: 101637045 Publication Model: eCollection Cited Medium: Print ISSN: 2328-8957 (Print) Linking ISSN: 23288957 NLM ISO Abbreviation: Open Forum Infect Dis Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: Cary, NC : Published by Oxford University Press on behalf of the Infectious Diseases Society of America, [2014]- |
| Abstract: | Background: Pregnancy increases Mycobacterium tuberculosis (Mtb) reactivation risk and alters immune responses. We assessed Mtb-specific CD4+ T-cell responses in pregnant women with HIV (WLHIV) and without, including those receiving isoniazid preventive therapy (IPT).; Methods: We measured adaptive immune responses from 33 participants (HIV+ 21, HIV- 12) with positive interferon-gamma release assay during pregnancy (20-34 weeks' gestation), 6 weeks, and 12 months postpartum by intracellular cytokine staining. We measured overall responses using COMPASS and made comparisons by nonparametric analysis of variance.; Result: We observed diminished Mtb-specific CD4+ T-cell responses in WLHIV during pregnancy versus 12 months postpartum (COMPASS median functional score [FS] .009 vs 0.12, P = .03). WLHIV who received IPT (n = 8) during concurrent pregnancy had attenuated Mtb-specific CD4+ T-cell responses during pregnancy versus 12 months postpartum (median FS 8.3 × 10-7 vs 0.13, P = .02), but WLHIV who did not receive IPT during pregnancy had similar responses in pregnancy and postpartum. Mtb-specific CD8+ FS was increased postpartum in all groups. We found preexisting Mtb-specific CD4+ T-cell responses in participants who converted interferon-gamma release assay tests postpartum (n = 10).; Conclusions: Pregnant WLHIV, especially those on IPT, showed reduced Mtb-specific CD4+ T-cell responses. Understanding the impact of pregnancy on Mtb-specific T-cell responses may improve diagnostic approaches.; (© The Author(s) 2025. Published by Oxford University Press on behalf of Infectious Diseases Society of America.) |
| Competing Interests: | Potential conflicts of interest. The authors declare that they do not have any association that might pose a conflict of interest. |
| References: | Semin Immunopathol. 2015 May;37(3):239-49. (PMID: 25917388); Mamm Genome. 2018 Aug;29(7-8):523-538. (PMID: 30116885); PLoS One. 2014 Mar 21;9(3):e92308. (PMID: 24658103); Nat Biotechnol. 2015 Jun;33(6):610-6. (PMID: 26006008); Nat Immunol. 2023 Jun;24(6):903-914. (PMID: 37156885); Scand J Immunol. 2004 Sep;60(3):273-7. (PMID: 15320884); Am J Respir Crit Care Med. 2017 Aug 15;196(4):502-511. (PMID: 28463648); Am J Respir Crit Care Med. 2012 Jan 15;185(2):206-12. (PMID: 22071329); AIDS. 2022 Aug 1;36(10):1363-1371. (PMID: 35608118); Semin Fetal Neonatal Med. 2009 Aug;14(4):234-40. (PMID: 19303830); Am J Respir Crit Care Med. 2012 Apr 1;185(7):779-84. (PMID: 22161161); Annu Rev Immunol. 2022 Apr 26;40:589-614. (PMID: 35130029); Oxf Open Immunol. 2023 Jul 08;4(1):iqad006. (PMID: 37554723); Lancet Glob Health. 2014 Dec;2(12):e710-6. (PMID: 25433626); Int J Gynaecol Obstet. 1994 Feb;44(2):119-24. (PMID: 7911094); Immunol Rev. 2013 Jul;254(1):54-64. (PMID: 23772614); Microbiol Spectr. 2022 Oct 26;10(5):e0117822. (PMID: 35969076); Eur Respir J. 2020 Mar 20;55(3):. (PMID: 31862768); Front Immunol. 2021 Aug 30;12:712480. (PMID: 34526988); Sci Immunol. 2017 Sep 1;2(15):. (PMID: 28864494); BMC Infect Dis. 2015 Oct 22;15:438. (PMID: 26493989); Nat Commun. 2016 Apr 12;7:11290. (PMID: 27068708); Eur Respir J. 2019 May 30;53(5):. (PMID: 30923183); J Acquir Immune Defic Syndr. 2022 Jan 1;89(1):98-107. (PMID: 34629414); Am J Respir Crit Care Med. 2003 Dec 1;168(11):1346-52. (PMID: 12969871); J Infect Dis. 2022 May 4;225(9):1663-1674. (PMID: 34929030); Int J Infect Dis. 2021 Nov;112:205-211. (PMID: 34517050); Nat Rev Microbiol. 2018 Feb;16(2):80-90. (PMID: 29109555); Clin Infect Dis. 2021 Nov 2;73(9):e3555-e3562. (PMID: 32720695); Am J Respir Crit Care Med. 2016 Jun 15;193(12):1421-8. (PMID: 26765255); J Infect Dis. 2023 Dec 20;228(12):1709-1719. (PMID: 37768184); PLoS One. 2018 Apr 4;13(4):e0193589. (PMID: 29617458) |
| Grant Information: | P30 AI168034 United States AI NIAID NIH HHS; R01 AI136921 United States AI NIAID NIH HHS; R21 HD098746 United States HD NICHD NIH HHS; K23 AI120793 United States AI NIAID NIH HHS; R01 AI142647 United States AI NIAID NIH HHS |
| Contributed Indexing: | Keywords: HIV; LTBI; T cells; isoniazid preventative therapy; pregnancy; tuberculosis |
| Entry Date(s): | Date Created: 20250221 Latest Revision: 20260306 |
| Update Code: | 20260306 |
| PubMed Central ID: | PMC11842132 |
| DOI: | 10.1093/ofid/ofaf067 |
| PMID: | 39981072 |
| Database: | MEDLINE |
Journal Article