Microbial dynamics and Pseudomonas natural product production in milk and dairy products.
| Title: | Microbial dynamics and Pseudomonas natural product production in milk and dairy products. |
|---|---|
| Authors: | Wasmuth I; Department of Paleobiotechnology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, 07745 Jena, Germany. christina_warinner@eva.mpg.de.; Institute of Organic Chemistry and Macromolecular Chemistry, Friedrich Schiller University Jena, 07743 Jena, Germany.; Warinner C; Department of Paleobiotechnology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, 07745 Jena, Germany. christina_warinner@eva.mpg.de.; Department of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany.; Associated Research Group of Archaeogenetics, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, 07745 Jena, Germany.; Faculty of Biological Sciences, Institute of Microbiology, Friedrich Schiller University Jena, 07743 Jena, Germany.; Department of Anthropology, Harvard University, Cambridge, MA 02138, USA.; Stallforth P; Department of Paleobiotechnology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, 07745 Jena, Germany. christina_warinner@eva.mpg.de.; Institute of Organic Chemistry and Macromolecular Chemistry, Friedrich Schiller University Jena, 07743 Jena, Germany. |
| Source: | Natural product reports [Nat Prod Rep] 2025 May 22; Vol. 42 (5), pp. 842-855. Date of Electronic Publication: 2025 May 22. |
| Publication Type: | Journal Article; Review; Research Support, Non-U.S. Gov't |
| Language: | English |
| Journal Info: | Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 8502408 Publication Model: Electronic Cited Medium: Internet ISSN: 1460-4752 (Electronic) Linking ISSN: 02650568 NLM ISO Abbreviation: Nat Prod Rep Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: [London, England] : Royal Society of Chemistry, c1984- |
| MeSH Terms: | Biological Products*/metabolism ; Biological Products*/chemistry ; Dairy Products*/microbiology ; Milk*/microbiology ; Pseudomonas*/metabolism; Animals ; Fermentation ; Humans |
| Abstract: | Covering: 2000 up to the first half of 2024Milk and its derived dairy products have long been integral to the human diet, with evidence of consumption dating back over 9000 years. Milk's high nutritional value renders dairy products an important element of human diet while also offering a fertile environment for microbial growth. Beneficial microorganisms in dairy products are often associated with biogenic and probiotic effects, whereas spoilage or pathogenic microorganisms can pose health risks. Fermentation is a key method to preserve milk. Whereas dairying practices in most parts of the world have been highly altered by industrialization over the past century, nomadic pastoralists in Mongolia notably retain a rich tradition of household-level dairy fermentation that has been practiced since 3000 BC. Milk-associated microorganisms produce a vast number of low molecular weight natural products that can mediate beneficial and detrimental interactions. Bacteria of the genus Pseudomonas are found in traditional Mongolian dairy products and are common contaminants in commercial dairy products, and they can strongly impact the quality and shelf-life of dairy products. These bacteria are well known for their ability to produce a variety of secondary metabolites, including nonribosomal (lipo)peptides, which are both structurally and functionally diverse. Lipopeptides can have antimicrobial properties, act as quorum sensing molecules, and contribute to biofilm formation due to their amphiphilic nature. Although often associated with spoilage, some of these natural products can also exhibit positive effects with potential beneficial applications in the dairy industry. This review aims to provide a comprehensive overview of the interplay between culinary fermentation and the production and activities of microbial-derived natural products. |
| Substance Nomenclature: | 0 (Biological Products) |
| Entry Date(s): | Date Created: 20250303 Date Completed: 20250522 Latest Revision: 20250811 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC11874467 |
| DOI: | 10.1039/d4np00074a |
| PMID: | 40028703 |
| Database: | MEDLINE |
Journal Article; Review; Research Support, Non-U.S. Gov't