Burden and Predictors of Statin Use for Primary and Secondary Prevention of Cardiovascular Disease in Bangladesh: Evidence from a Nationally Representative Survey.
| Title: | Burden and Predictors of Statin Use for Primary and Secondary Prevention of Cardiovascular Disease in Bangladesh: Evidence from a Nationally Representative Survey. |
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| Authors: | Al Abid SU; Department of Epidemiology & Research, National Heart Foundation Hospital and Research Institute, Dhaka, Bangladesh.; Monower MM; Department of Epidemiology & Research, National Heart Foundation Hospital and Research Institute, Dhaka, Bangladesh.; Abrar AK; Department of Epidemiology & Research, National Heart Foundation Hospital and Research Institute, Dhaka, Bangladesh.; Riva JA; Ad-din Women's Medical College Hospital, Outer Circular Rd, Dhaka 1217, Bangladesh.; Bhuiyan MR; Department of Epidemiology & Research, National Heart Foundation Hospital and Research Institute, Dhaka, Bangladesh.; Al-Mamun MA; Department of Epidemiology & Research, National Heart Foundation Hospital and Research Institute, Dhaka, Bangladesh.; Choudhury SR; Department of Epidemiology & Research, National Heart Foundation Hospital and Research Institute, Dhaka, Bangladesh. |
| Source: | Global heart [Glob Heart] 2025 Mar 12; Vol. 20 (1), pp. 28. Date of Electronic Publication: 2025 Mar 12 (Print Publication: 2025). |
| Publication Type: | Journal Article; Multicenter Study |
| Language: | English |
| Journal Info: | Publisher: Ubiquity Press Country of Publication: England NLM ID: 101584391 Publication Model: eCollection Cited Medium: Internet ISSN: 2211-8179 (Electronic) Linking ISSN: 22118160 NLM ISO Abbreviation: Glob Heart Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2020- : [London] : Ubiquity Press; Original Publication: [Oxford] : Elsevier Ltd. |
| MeSH Terms: | Hydroxymethylglutaryl-CoA Reductase Inhibitors*/therapeutic use ; Cardiovascular Diseases*/prevention & control ; Cardiovascular Diseases*/epidemiology ; Primary Prevention*/methods ; Secondary Prevention*/methods; Bangladesh/epidemiology ; Humans ; Middle Aged ; Male ; Female ; Adult ; Aged |
| Abstract: | Background: Large-scale randomized trials have established the efficacy and safety of statin therapy in preventing cardiovascular diseases (CVDs) among individuals at increased risk (i.e., primary prevention) or those with pre-existing cardiovascular disease (i.e., secondary prevention). Consequently, recent international guidelines, including those from the WHO and ACC/AHA, have expanded the eligibility criteria for statin therapy.; Objective: To assess the current burden of statin-eligible populations in Bangladesh, evaluate the current state of statin use, and identify factors associated with non-use of statins.; Methods: We analysed data from 3,140 adults aged 40 to 69 years from the nationally representative WHO-STEPS Bangladesh 2018 survey. Statin therapy eligibility for primary prevention was assessed using the WHO-2019 and the ACC/AHA-2018 guidelines separately. Individuals with a previous history of CVD were eligible for secondary prevention under both guidelines. Modified Poisson regression models identified factors associated with statin use. All analyses were conducted using appropriate survey weights.; Findings: Among the participants, 443 (14.1%) reported a previous history of CVD. Of those without CVD, 11.2% (95% CI: 9.7-12.9) and 32.3% (95% CI: 30.0-34.6) were eligible for statin use for primary prevention according to the WHO-2019 and the ACC/AHA-2018 guidelines, respectively. Among adults eligible according to WHO-2019 guideline, 6.9% (95% CI: 4.1-11.5) were using statins, while among those eligible according to ACC/AHA-2018 guideline, 3.3% (95% CI: 2.1-5.1) were using statins. For secondary prevention, 23.5% (95% CI: 16.9-31.6) of adults with prior CVD were using statins. Non-use was higher among younger adults, those without regular health visits or cholesterol measurements, and those from the Mymensingh or Rajshahi divisions.; Interpretation: In Bangladesh, approximately one in twenty eligible individuals uses statins for primary prevention of CVD, and one in five individuals for secondary prevention. Appropriate population health interventions are needed to scale up statin use to mitigate the burden of CVD.; (Copyright: © 2025 The Author(s).) |
| Competing Interests: | The authors have no competing interests to declare. |
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| Contributed Indexing: | Keywords: ACC/AHA; Bangladesh; Primary prevention; WHO; cardiovascular disease; statins |
| Substance Nomenclature: | 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors) |
| Entry Date(s): | Date Created: 20250317 Date Completed: 20250317 Latest Revision: 20260511 |
| Update Code: | 20260511 |
| PubMed Central ID: | PMC11908426 |
| DOI: | 10.5334/gh.1412 |
| PMID: | 40094069 |
| Database: | MEDLINE |
Journal Article; Multicenter Study