Imported fever in returning travellers and migrants in Spain, 2009-2021. Analysis by the +REDIVI network.
| Title: | Imported fever in returning travellers and migrants in Spain, 2009-2021. Analysis by the +REDIVI network. |
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| Authors: | Guevara-Hernández P; Infectious Diseases Unit-Internal Medicine Department, Vega Baja Hospital, Orihuela, Spain. Electronic address: pegueher@gmail.com.; Llenas-García J; Infectious Diseases Unit-Internal Medicine Department, Vega Baja Hospital, Orihuela, Spain; Foundation for the Promotion of Health and Biomedical Research of the Valencia Region (FISABIO), Valencia, Spain; Clinical Medicine Department, Miguel Hernández University, Elche, Spain; CIBERINFEC, Carlos III Health Institute, Madrid, Spain. Electronic address: jarallenas@gmail.com.; Díaz-Menéndez M; CIBERINFEC, Carlos III Health Institute, Madrid, Spain; National Referral Unit for Imported Diseases and International Health, High Level Isolation Unit, La Paz-Carlos III-CB University Hospital (IdiPaz), Madrid, Spain. Electronic address: marta.diazmenendez@gmail.com.; Serre-Delcor N; CIBERINFEC, Carlos III Health Institute, Madrid, Spain; Tropical Diseases and Global Health Unit Drassanes-Vall d'Hebron, Infectious Diseases Department, Vall d'Hebron Hospital, PROSICS Barcelona, Barcelona, Spain. Electronic address: nuria.serre@vallhebron.cat.; Crespillo-Andújar C; CIBERINFEC, Carlos III Health Institute, Madrid, Spain; National Reference Centre for Tropical Diseases. Infectious Diseases Department, Ramón y Cajal University Hospital, IRYCIS, Madrid, Spain. Electronic address: clara.crespillo@gmail.com.; Salvador F; CIBERINFEC, Carlos III Health Institute, Madrid, Spain; Infectious Diseases Department, Vall d'Hebron University Hospital, PROSICS Barcelona, Spain. Electronic address: fernando.salvador@vallhebron.cat.; Ruiz-Giardin JM; CIBERINFEC, Carlos III Health Institute, Madrid, Spain; Infectious Diseases Unit-Internal Medicine Department. Fuenlabrada University Hospital, Madrid, Spain. Electronic address: josemanuel.ruiz@salud.madrid.org.; Goikoetxea-Agirre J; Infectious Diseases Department, Cruces University Hospital, 48903, Bilbao, Spain. Electronic address: anejosune.goikoetxeaagirre@gmail.com.; Torrús-Tendero D; Imported Diseases and Global Health Reference Unit, Dr. Balmis University General Hospital, Alicante, SpainISABIAL; Parasitology Area, Miguel Hernández University, Spain. Electronic address: torrus_die@gva.es.; de la Calle-Prieto F; National Referral Unit for Imported Diseases and International Health, High Level Isolation Unit, La Paz-Carlos III-CB University Hospital (IdiPaz), Madrid, Spain. Electronic address: fcalle.prieto@salud.madrid.org.; Oliveira-Souto I; CIBERINFEC, Carlos III Health Institute, Madrid, Spain; Tropical Diseases and Global Health Unit Drassanes-Vall d'Hebron, Infectious Diseases Department, Vall d'Hebron Hospital, PROSICS Barcelona, Barcelona, Spain. Electronic address: ines.oliveira@vallhebron.cat.; Bosch-Nicolau P; CIBERINFEC, Carlos III Health Institute, Madrid, Spain; Infectious Diseases Department, Vall d'Hebron University Hospital, PROSICS Barcelona, Spain. Electronic address: pau.boschnicolau@gmail.com.; Wikman P; Clinical Medicine Department, Miguel Hernández University, Elche, Spain; Infectious Diseases Unit-Internal Medicine Department, Elda University Hospital, Spain. Electronic address: pwikman@umh.es.; Pérez-Molina JA; CIBERINFEC, Carlos III Health Institute, Madrid, Spain; National Reference Centre for Tropical Diseases. Infectious Diseases Department, Ramón y Cajal University Hospital, IRYCIS, Madrid, Spain. Electronic address: jperezm@salud.madrid.org. |
| Corporate Authors: | +Redivi study group |
| Source: | Travel medicine and infectious disease [Travel Med Infect Dis] 2025 May-Jun; Vol. 65, pp. 102833. Date of Electronic Publication: 2025 Mar 15. |
| Publication Type: | Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't |
| Language: | English |
| Journal Info: | Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 101230758 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-0442 (Electronic) Linking ISSN: 14778939 NLM ISO Abbreviation: Travel Med Infect Dis Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Amsterdam : Elsevier Science, 2003- |
| MeSH Terms: | Fever*/epidemiology ; Fever*/etiology ; Transients and Migrants*/statistics & numerical data ; Travel*/statistics & numerical data ; Communicable Diseases, Imported*/epidemiology; Spain/epidemiology ; Dengue/epidemiology ; Malaria/epidemiology ; Humans ; Prospective Studies ; Female ; Male ; Adult ; Middle Aged ; Young Adult ; Adolescent ; Aged ; Child ; Child, Preschool |
| Abstract: | Background: Travellers and migrants commonly present to health services with febrile syndrome, which can have different causes, including some that are life-threatening. A better understanding of these causes may help guide management and determine appropriate empirical treatments.; Objectives: The aim was to identify the leading causes of fever and to assess their association with the region of travel and type of travellers.; Methods: This prospective, multicentre study was conducted within the +REDIVI network. Data were collected on febrile syndrome cases among migrants, travellers, and people visiting friends and relatives (VFRs) from 2009 to 2021. Comparative analyses were performed according to patient categories and regions of travel/origin.; Results: Of the 4186 patients with febrile syndrome, the most frequent diagnosis was malaria (31.0 %), followed by dengue fever (12.0 %) and nonspecific fever of less than three weeks' duration (11.6 %). Malaria predominated in people coming from sub-Saharan Africa (58.4 %), while dengue fever was more common in the rest of the regions (19.0 % in South America, 25.0 % in Central America and the Caribbean, 34.2 % in Southeast Asia, and 18.1 % in South-Central Asia). By type of traveller, tuberculosis was more frequent in migrants, malaria in VFRs, and dengue and other arboviral infections in travellers and VFRs.; Conclusions: Geographical area of travel and type of traveller are the main determinants of imported fever aetiology. Malaria remains the most common cause of febrile syndrome, especially in VFRs from sub-Saharan Africa, while dengue fever prevails in the other tropical regions.; (Copyright © 2025 The Authors. Published by Elsevier Ltd.. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Arboviruses; Dengue; Fever; Imported fever; Malaria; Migrant; Travel medicine; Travel-related illness |
| Entry Date(s): | Date Created: 20250317 Date Completed: 20250516 Latest Revision: 20260507 |
| Update Code: | 20260508 |
| DOI: | 10.1016/j.tmaid.2025.102833 |
| PMID: | 40097032 |
| Database: | MEDLINE |
Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't