Neonatal Survival Following Spontaneous Maternal Recovery From Ebola Virus Disease in a Resource-Limited Setting in Western Democratic Republic of the Congo.
| Title: | Neonatal Survival Following Spontaneous Maternal Recovery From Ebola Virus Disease in a Resource-Limited Setting in Western Democratic Republic of the Congo. |
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| Authors: | Imani-Musimwa P; Department of Obstetrics and Gynecology, School of Medicine, University of Goma, Goma, Democratic Republic of the Congo.; Département de Santé, Centre Régional d'Expertise en Recherche et Actions Humanitaires, Bukavu, Democratic Republic of the Congo.; Department of Epidemiology, School of Public Health, University of Goma, Goma, Democratic Republic of the Congo.; Grant E; Département de Santé, Centre Régional d'Expertise en Recherche et Actions Humanitaires, Bukavu, Democratic Republic of the Congo.; Mukadi-Bamuleka D; Département de Virologie, Institut National de Recherche Biomédicale (INRB), Kinshasa, Democratic Republic of the Congo.; Department of Medical Biology, School of Medicine, University of Kinshasa, Kinshasa, Democratic Republic of the Congo.; Department of Virology and Molecular Biology, Rodolphe Mérieux INRB-Goma Laboratory, Goma, North Kivu, Democratic Republic of the Congo.; Fraterne-Muhayangabo R; Département de Santé, Centre Régional d'Expertise en Recherche et Actions Humanitaires, Bukavu, Democratic Republic of the Congo.; Department of Epidemiology, School of Public Health, University of Goma, Goma, Democratic Republic of the Congo.; Kitenge-Omasumbu R; Centre des Opérations d'Urgences de Santé Publique (COUSP), Ministère de la Santé Publique, Hygiène et Prévention, Kinshasa, Democratic Republic of the Congo.; Mbala-Kingebeni P; Département de Virologie, Institut National de Recherche Biomédicale (INRB), Kinshasa, Democratic Republic of the Congo.; Department of Medical Biology, School of Medicine, University of Kinshasa, Kinshasa, Democratic Republic of the Congo.; Tsongo-Kibendelwa Z; Department of Epidemiology, School of Public Health, University of Goma, Goma, Democratic Republic of the Congo.; Department of Internal Medicine, School of Medicine, University of Kisangani, Kisangani, Democratic Republic of the Congo.; Nyakio-Ngeleza O; Department of Obstetrics and Gynecology, School of Medicine, Official University of Bukavu, Bukavu, Democratic Republic of the Congo.; Claris-Mwatsi I; Département de Santé, Centre Régional d'Expertise en Recherche et Actions Humanitaires, Bukavu, Democratic Republic of the Congo.; Department of Epidemiology, School of Public Health, University of Goma, Goma, Democratic Republic of the Congo.; Sihali-Kyolov J; Department of Obstetrics and Gynecology, School of Medicine, University of Kisangani, Kisangani, Democratic Republic of the Congo.; Barhwamire-Kabesha T; Department of Surgery, School of Medicine, Official University of Bukavu, Bukavu, Democratic Republic of the Congo.; Kavira-Malengera C; Department of Epidemiology, School of Public Health, University of Goma, Goma, Democratic Republic of the Congo.; Département de Nutrition et santé, Centre de Recherche en Sciences Naturelles de Lwiro (CRSN-Lwiro), Bukavu, Democratic Republic of the Congo.; Feza-Malira M; Département de Santé, Centre Régional d'Expertise en Recherche et Actions Humanitaires, Bukavu, Democratic Republic of the Congo.; Department of Epidemiology, School of Public Health, University of Goma, Goma, Democratic Republic of the Congo.; Bitwe-Mihanda R; Department of Epidemiology, School of Public Health, University of Goma, Goma, Democratic Republic of the Congo.; Department of Pediatrics and Neonatology, School of Medicine, University of Goma, Goma, Democratic Republic of the Congo.; Sengeyi-Mushengezi-Amani D; Department of Obstetrics and Gynecology, School of Medicine, University of Kinshasa, Kinshasa, Democratic Republic of the Congo.; Ververs M; Center for Humanitarian Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA. |
| Source: | Case reports in infectious diseases [Case Rep Infect Dis] 2025 Mar 14; Vol. 2025, pp. 2987569. Date of Electronic Publication: 2025 Mar 14 (Print Publication: 2025). |
| Publication Type: | Case Reports; Journal Article |
| Language: | English |
| Journal Info: | Publisher: Wiley Country of Publication: Egypt NLM ID: 101573243 Publication Model: eCollection Cited Medium: Print ISSN: 2090-6625 (Print) Linking ISSN: 20906633 NLM ISO Abbreviation: Case Rep Infect Dis Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Publication: 2023- : [Hoboken, NJ] : Wiley; Original Publication: Cairo : Hindawi Pub. Corp. |
| Abstract: | Background: Pregnancy induces physiological decline in maternal immunity. Ebola virus disease (EVD) in pregnancy is associated with obstetrical complications, and vaccination in early pregnancy is recommended, but may not be without risk. Case Presentation: We described neonatal survival after spontaneous maternal EVD recovery. This neonate was born to a 25-year-old mother admitted to an Ebola Treatment Unit (ETU) in July, 2020, after 11 days of symptoms. She was vaccinated with rVSV-ZEBOV three days before symptom onset and her real-time polymerase chain of reaction (RT-PCR) results confirmed EVD and malarial infection two days after, but she refused hospitalization. She was treated at home with PO ASAQ, amoxicillin, paracetamol, albendazole, omeprazole, and papaverine. Eleven days later, due to clinical deterioration and onset of vaginal hemorrhage, she finally accepted to be transferred in ETU. She was Parity 2, fetal age at admission was 5 weeks and 3 days. Upon admission, her EVD PCR measured NP 26.3 and GP 32.9. She did not receive monoclonal therapy against Ebola infection due to stock shortage. She received intravenous, artesunate, ceftriaxone, and papaverine. She experienced spontaneous resolution of EVD 18 days after symptom onset and was discharged. At 40 weeks gestation, seven and a half months after EVD recovery, she delivered a healthy female infant, APGAR 10/10/10, weighing 3450 g. Maternal blood, adnexal, and newborn blood samples were RT-PCR negative, and the mother and the baby were discharged after 14 days. At our last follow-up, in June 2023 (2 years, 3 months after delivery), the mother and the baby were in good health. Conclusion: Neonatal survival following spontaneous maternal recovery from EVD in the first trimester of gestation is rare but possible, even in the context of limited clinical resources for treatment.; (Copyright © 2025 Prince Imani-Musimwa et al. Case Reports in Infectious Diseases published by John Wiley & Sons Ltd.) |
| Competing Interests: | The authors declare no conflicts of interest. |
| References: | PLoS One. 2023 Sep 8;18(9):e0286843. (PMID: 37682812); Front Immunol. 2020 Oct 07;11:575197. (PMID: 33133091); Int J Gynaecol Obstet. 2018 Jul;142(1):71-77. (PMID: 29569244); Lancet Microbe. 2024 Feb;5(2):e109-e118. (PMID: 38278165); Clin Case Rep. 2023 Nov 22;11(11):e8253. (PMID: 38028078); Birth Defects Res. 2017 Mar 15;109(5):353-362. (PMID: 28398679); N Engl J Med. 2019 Dec 12;381(24):2293-2303. (PMID: 31774950); Emerg Infect Dis. 2020 Mar;26(3):541-548. (PMID: 32017677); Infect Dis Poverty. 2017 Oct 11;6(1):135. (PMID: 29017587); J Pathol. 2015 Jan;235(2):153-74. (PMID: 25297522); Lancet Infect Dis. 2020 Jul;20(7):e149-e158. (PMID: 32595045); Clin Dev Immunol. 2012;2012:985646. (PMID: 22235228); Future Microbiol. 2020 Jan;15:85-106. (PMID: 32030996); J Infect Public Health. 2024 Jan;17(1):25-34. (PMID: 37992431); Euro Surveill. 2014 Dec 11;19(49):. (PMID: 25523968) |
| Contributed Indexing: | Keywords: DR Congo; Ebola and pregnancy; limited resources; neonatal survival; spontaneous recovery |
| Entry Date(s): | Date Created: 20250324 Latest Revision: 20250325 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC11928211 |
| DOI: | 10.1155/crdi/2987569 |
| PMID: | 40125488 |
| Database: | MEDLINE |
Case Reports; Journal Article