Effects Atra on MMP-9 Activity and Integrin Expression in Choriocarcinoma Culture Cell Line Bewo (ATCC CCL-98).
| Title: | Effects Atra on MMP-9 Activity and Integrin Expression in Choriocarcinoma Culture Cell Line Bewo (ATCC CCL-98). |
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| Authors: | Nurseta T; Department of Obstetrics and Gynecology, Faculty of Medicine, Brawijaya University, Malang, Indonesia.; Indrawan IWA; Department of Obstetrics and Gynecology, Faculty of Medicine, Brawijaya University, Malang, Indonesia.; Gunawan DA; Department of Obstetrics and Gynecology, Ngudi Waluyu Hospital Wlingi, East Java, Indonesia.; Pramudia Wardani KR; Department of Obstetrics and Gynecology, Faculty of Medicine, Brawijaya University, Malang, Indonesia. |
| Source: | Asian Pacific journal of cancer prevention : APJCP [Asian Pac J Cancer Prev] 2025 Mar 01; Vol. 26 (3), pp. 1027-1033. Date of Electronic Publication: 2025 Mar 01. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Asian Pacific Organization for Cancer Prevention Country of Publication: Thailand NLM ID: 101130625 Publication Model: Electronic Cited Medium: Internet ISSN: 2476-762X (Electronic) Linking ISSN: 15137368 NLM ISO Abbreviation: Asian Pac J Cancer Prev Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Bangkok : Asian Pacific Organization for Cancer Prevention |
| MeSH Terms: | Matrix Metalloproteinase 9*/metabolism ; Choriocarcinoma*/metabolism ; Choriocarcinoma*/drug therapy ; Choriocarcinoma*/pathology ; Tretinoin*/pharmacology ; Uterine Neoplasms*/metabolism ; Uterine Neoplasms*/drug therapy ; Uterine Neoplasms*/pathology ; Integrins*/metabolism ; Antineoplastic Agents*/pharmacology; Cell Proliferation/drug effects ; Humans ; Female ; Tumor Cells, Cultured ; Cell Line, Tumor |
| Abstract: | Objective: Choriocarcinoma is characterized by aggressive growth and metastasis, and integrins and matrix metalloproteinase-9 (MMP-9) play crucial roles in its progression. ATRA (All-trans retinoic acid) has been shown to have anti-tumor effects in various cancers, poses a 15-20% malignancy risk. This study investigates the effects ATRA on MMP-9 activity and integrin expression in the choriocarcinoma cell line BeWo, and to explore the potential mechanisms underlying these effects.; Methods: This is an experimental study using choriocarcinoma cell line BeWo. Six treatment groups were established to varying concentrations of ATR and one group served as a control without ATRA exposure. The groups were labelled with fluorescence and performed with flowcytometry to determine MMP-9 and integrin expression. Data was presented as mean ± SD and analyzed using one-way ANOVA with post-hoc tests in which p-value |
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| Contributed Indexing: | Keywords: ATRA; Choriocarcinoma; MMP-9; integrim; retinoic acid |
| Substance Nomenclature: | EC 3.4.24.35 (Matrix Metalloproteinase 9); 5688UTC01R (Tretinoin); EC 3.4.24.35 (MMP9 protein, human); 0 (Integrins); 0 (Antineoplastic Agents) |
| Entry Date(s): | Date Created: 20250329 Date Completed: 20250515 Latest Revision: 20250705 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC12174550 |
| DOI: | 10.31557/APJCP.2025.26.3.1027 |
| PMID: | 40156421 |
| Database: | MEDLINE |
Journal Article