No Distinct Cytokine, Chemokine, and Growth Factor Blood Profile Associated With Monkeypox Virus Clade IIb Infected Patients.
| Title: | No Distinct Cytokine, Chemokine, and Growth Factor Blood Profile Associated With Monkeypox Virus Clade IIb Infected Patients. |
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| Authors: | Bangwen E; Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.; Virology, Antiviral Drug & Vaccine Research Group, Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium.; Berens-Riha N; Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.; de Vrij N; Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.; Adrem Data Lab, Department of Computer Science, University of Antwerp, Antwerp, Belgium.; Ceulemans A; Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.; Brosius I; Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.; De Vos E; Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.; Pham TT; Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.; Bottieau E; Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.; van Griensven J; Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.; Netongo PM; Molecular Diagnostics Research Group, Biotechnology Centre-University of Yaounde I (BTC-UYI), Yaounde, Cameroon.; Biology Program, School of Science, Navajo Technical University, Crownpoint, New Mexico, USA.; Van Esbroeck M; Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.; Vercauteren K; Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.; Van Dijck C; Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.; Adriaensen W; Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.; Liesenborghs L; Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.; Virology, Antiviral Drug & Vaccine Research Group, Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium. |
| Source: | Journal of medical virology [J Med Virol] 2025 Apr; Vol. 97 (4), pp. e70320. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Wiley-Liss Country of Publication: United States NLM ID: 7705876 Publication Model: Print Cited Medium: Internet ISSN: 1096-9071 (Electronic) Linking ISSN: 01466615 NLM ISO Abbreviation: J Med Virol Subsets: MEDLINE |
| Imprint Name(s): | Publication: New York Ny : Wiley-Liss; Original Publication: New York, Liss. |
| MeSH Terms: | Chemokines*/blood ; Cytokines*/blood ; Intercellular Signaling Peptides and Proteins*/blood ; Monkeypox virus*/classification ; Mpox, Monkeypox*/immunology ; Mpox, Monkeypox*/virology; Adult ; Aged ; Humans ; Male ; Middle Aged ; Young Adult ; Belgium |
| Abstract: | Previous studies indicated Clade I monkeypox virus infection to be associated with marked elevation of proinflammatory cytokines. This remains unexplored for Clade II-associated disease, which has different clinical manifestations and prognosis. We used a 65-plex cytokine, chemokine, and growth factor (CCG) panel to analyze serum samples of 100 male acute Clade IIb mpox patients and 26 healthy controls in Belgium. Cluster analyses revealed no strong or distinct CCG profiles distinguishing mpox patients from controls but suggested trends in certain cytokine modulation. Individual CCG analyses found elevated levels of cytokines (MIF, CD30, IL2R, IL18, APRIL, and TNFRII), chemokines (CCL4, CCL8, CCL22, CCL24, CXCL9, CXCL10, CXCL11, CXCL12, and CXCL13), and growth factors (HGF and VEGFA) in patients, while CCL11 and CXCL5 were significantly suppressed. We detected no differences in key proinflammatory cytokines, IL-1α, IL-1β, IL-6, IL-8 or anti-inflammatory cytokines, IL-4, IL-10, IL-13. In patients living with HIV, comparison with pre-outbreak samples showed an increase in CXCL13 and a decrease in CXCL5, CCL2, CCL24, HGF, SCF, and TWEAK. The absence of discriminatory CCG profiles in Clade IIb mpox patients compared to healthy controls suggests there may be limited clinical applications of those markers.; (© 2025 The Author(s). Journal of Medical Virology published by Wiley Periodicals LLC.) |
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| Grant Information: | This work was funded by the Agency of Care and Health, the Department of Economy, Science, and Innovation of the Flemish government (EWI), the Research Foundation-Flanders FWO (Grants G096222N to E.Bo. and L.L., 1S71721N to N.d.V., and 12B1M24N to C.v.D) and the African coaLition for Epidemic Research Response (ALERRT) EDCTP2 (Grant RIA2016E-1612). ALERRT is also supported by the United Kingdom National Institute for Health Research. |
| Contributed Indexing: | Keywords: cytokines; immunology of mpox; monkeypox virus; mpox |
| Substance Nomenclature: | 0 (Chemokines); 0 (Cytokines); 0 (Intercellular Signaling Peptides and Proteins) |
| Entry Date(s): | Date Created: 20250329 Date Completed: 20250515 Latest Revision: 20250606 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC11954153 |
| DOI: | 10.1002/jmv.70320 |
| PMID: | 40156483 |
| Database: | MEDLINE |
Journal Article